Neurotrophic Keratitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: A Study of STSP-0902 Ophthalmic Solution in Healthy Subjects [Phase 1]
A Phase 1 trial evaluating the safety and tolerability of STSP-0902 ophthalmic solution in healthy volunteers has been completed for neurotr…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Phase II Study of STSP-0902 Ophthalmic Solution in Patients With Neurotrophic Keratitis [Phase 2]
Phase II clinical trial update for STSP-0902 ophthalmic solution in neurotrophic keratitis, currently recruiting.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis [Phase 1, Phase 2]
Krystal Biotech is conducting a Phase 1/2 trial to compare KB801 with placebo in patients with Stage 2 or Stage 3 neurotrophic keratitis, cu…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: QST for Corneal Nerve Function [NA]
The Tufts Medical Center-sponsored trial evaluating quantitative sensory testing for corneal nerve function has been suspended.
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: DEFENDO Long Term Follow-up Study in Stage 1 NK Patients
The DEFENDO long-term follow-up study in Stage 1 Neurotrophic Keratitis patients has completed enrollment and posted results on 2025-11-28.
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: To Evaluate the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects Caused by Neurotrophic Keratitis [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of ZKY001 Eye Drops for corneal epithelial defects caused by neurotrophic kerati…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study [NA]
A pilot clinical trial compares corneal neurotization versus cenegermin for neurotrophic keratitis and is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-14Clinical Trial Update: REC 0/0559 Eye Drops for Treatment of Moderate and Severe Neurotrophic Keratitis in Adult Patients [Phase 2]
A Phase 2 clinical trial by Recordati Group evaluating investigational eye drops for moderate to severe Neurotrophic keratitis in adults has…
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CLINICAL_TRIALS research · 2025-05-11Clinical Trial Update: Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease [Phase 4]
Phase 4 study evaluating Acthar Gel delivered via a single-dose pre-filled SelfJect injector in patients with autoimmune diseases and kerati…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: DOMPE -MT Neurotrophic Keratitis [Phase 4]
A Phase 4 clinical trial update for DOMPE-MT in neurotrophic keratitis, with associated dry eye disease, noting the study is active but not …
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CLINICAL_TRIALS trial_result · 2025-04-01Clinical Trial Update: Corneal Nerves After Treatment With Cenegermin
This clinical trial update reports on corneal nerve outcomes after treatment with cenegermin in neurotrophic keratitis, and the study status…
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CLINICAL_TRIALS withdrawal · 2025-02-06Clinical Trial Update: Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis [Phase 4]
A Phase 4 trial evaluating Plasma Rich in Growth Factors (PRGF-Endoret) eye drops for neurotrophic keratitis has been withdrawn.
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CLINICAL_TRIALS other · 2025-01-15Clinical Trial Update: Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye
This clinical trial comparing corneal structure and function in Sjögren's syndrome–related dry eye versus non-Sjögren dry eye was terminated…
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CLINICAL_TRIALS withdrawal · 2024-12-02Clinical Trial Update: Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis [Phase 4]
The Phase 4 open-label trial evaluating cenegermin (rhNGF) for corneal thickness in neurotrophic keratitis via AS-OCT has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: Assessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic Keratitis [Phase 2]
Phase 2 clinical trial update evaluating the initial efficacy and safety of BRM424 ophthalmic solution in neurotrophic keratitis; the study …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis Subjects [Phase 1, Phase 2]
A Phase 1/2 study evaluating the safety and efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis has completed.
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CLINICAL_TRIALS withdrawal · 2024-02-05Clinical Trial Update: Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy. [Phase 2, Phase 3]
A clinical trial investigating topical insulin drops for neurotrophic keratopathy has been withdrawn after Phase 2/3.
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FDA approval · 2023-10-20FDA Approved: OXERVATE — Supplemental Application (Domp farmaceutici S.p.A.)
FDA approves a supplemental application for Oxervate (cenegermin-bkbj) from Domp farmaceutici S.p.A., marking FDA approval of the requested …
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CLINICAL_TRIALS trial_result · 2023-06-23Clinical Trial Update: Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis [Phase 4]
Phase 4 clinical trial evaluating OXERVATE (cenegermin) for stage 1 neurotrophic keratitis has completed with results posted.
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FDA approval · 2019-10-30FDA Approved: OXERVATE — Supplemental Application (Domp farmaceutici S.p.A.)
FDA approved a supplemental application for Oxervate (cenegermin-bkbj) submitted by Dompé farmaceutici S.p.A.
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CLINICAL_TRIALS trial_result · 2019-10-07Clinical Trial Update: Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer [Phase 3]
Phase 3 trial comparing T4020 to vehicle in chronic neurotrophic keratitis or corneal ulcer completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-07-29Clinical Trial Update: Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. [Phase 1, Phase 2]
Clinical trial evaluating safety and efficacy of rhNGF in stage 2–3 neurotrophic keratitis completed with results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-06-14Clinical Trial Update: Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK [Phase 2]
Phase 2 trial evaluating the efficacy of a new formulation of rhNGF at 20 µg/ml with antioxidant in Neurotrophic Keratitis completed (result…
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FDA approval · 2018-08-22FDA Approved: OXERVATE — Original Application (Domp farmaceutici S.p.A.)
FDA approved Oxervate (cenegermin-bkbj) from Dompé Farmaceutici as a first-in-class therapy for neurotrophic keratitis, a rare corneal disea…