Neuromyelitis Optica
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: Evaluate the Safety and Efficacy of CAR-T Cells in the Treatment of R/R Neuromyelitis Optica [Phase 1]
Phase 1 clinical trial evaluating the safety and efficacy of CAR-T cell therapy for relapsed/refractory Neuromyelitis Optica has completed. …
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Safety and Efficacy of Daratumumab in Patients With Anti-Aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorders [Phase 2, Phase 3]
Clinical trial update notes safety and efficacy evaluation of daratumumab in patients with anti-AQP4 antibody positive neuromyelitis optica …
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CLINICAL_TRIALS trial_result · 2024-09-25Clinical Trial Update: A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder [Phase 2, Phase 3]
A pediatric Phase 2/3 trial of eculizumab for relapsing neuromyelitis optica spectrum disorder was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: In Vitro Study of the Biological and Immunological Activity of Imotopes® Candidates on Blood Cells of Patients With Stabilized NMO [NA]
An in vitro study assesses the biological and immunological activity of Imotopes candidate compounds on blood cells from patients with stabi…
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: A Longitudinal Study of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active NMOSD [Phase 1, Phase 2]
A longitudinal Phase 1/2 trial evaluating ACTEMRA (tocilizumab) as monotherapy in highly active neuromyelitis optica spectrum disorders has …
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CLINICAL_TRIALS trial_result · 2023-08-09Clinical Trial Update: An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSD [Phase 3]
Phase 3 trial of ravulizumab in adults with neuromyelitis optica spectrum disorder has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2023-06-07Clinical Trial Update: Neuromyelitis Optica (NMO) & Cetirizine [Phase 1, Phase 2]
A Phase 1/2 clinical trial investigating cetirizine for Neuromyelitis Optica has completed with results posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-08-23Clinical Trial Update: An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients [Phase 3]
Open-label extension of eculizumab in relapsing neuromyelitis optica shows continuing assessment in a Phase 3 study.
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CLINICAL_TRIALS trial_result · 2020-12-31Clinical Trial Update: Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD) [Phase 3]
Phase 3 trial evaluating satralizumab as add-on therapy for neuromyelitis optica and NMOSD completed with posted results.
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CLINICAL_TRIALS trial_result · 2020-12-31Clinical Trial Update: Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Treat Participants With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) [Phase 3]
A Phase 3 trial evaluated satralizumab as monotherapy for neuromyelitis optica and NMOSD, with completed status and results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-12-28Clinical Trial Update: A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease) [Phase 4]
Pilot Phase 4 trial investigating mitoxantrone for recurrent neuromyelitis optica (Devic's disease) has completed.
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CLINICAL_TRIALS trial_result · 2020-04-17Clinical Trial Update: Scrambler Trial for Pain in NMOSD [NA]
A completed NMOSD pain trial (Scrambler) with posted results.
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CLINICAL_TRIALS trial_result · 2019-12-26Clinical Trial Update: N-MOmentum: A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorders [Phase 2, Phase 3]
A completed Phase 2/3 clinical trial evaluating inebilizumab for Neuromyelitis Optica Spectrum Disorders.
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CLINICAL_TRIALS trial_result · 2019-10-24Clinical Trial Update: Tocilizumab vs Azathioprine in Neuromyelitis Optica Spectrum Disorders [Phase 2, Phase 3]
A Phase 2/3 trial comparing tocilizumab to azathioprine in neuromyelitis optica spectrum disorders (NMOSD) has completed.
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CLINICAL_TRIALS trial_result · 2019-06-26Clinical Trial Update: A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study) [Phase 3]
Phase 3 randomized trial of eculizumab in AQP4 antibody-positive neuromyelitis optica spectrum disorder was terminated; results posted in 20…
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CLINICAL_TRIALS trial_result · 2019-06-06Clinical Trial Update: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses [Phase 1]
Phase 1 trial update evaluating ublituximab for relapses in neuromyelitis optica and related spectrum disorders; results posted after comple…
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: Autologous Hematopoietic Stem Cell Transplant in Neuromyelitis Optica [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating autologous hematopoietic stem cell transplant in Neuromyelitis Optica has been terminated.
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CLINICAL_TRIALS trial_result · 2018-04-17Clinical Trial Update: Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) [Phase 2]
A Phase 2 clinical trial evaluating sustained-release dalfampridine for transverse myelitis and related conditions has completed, with resul…
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CLINICAL_TRIALS trial_result · 2016-07-20Clinical Trial Update: A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis [Phase 3]
A Phase 3 multicenter randomized trial comparing intravenous immunoglobulin to standard therapy for transverse myelitis has been terminated.
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CLINICAL_TRIALS trial_result · 2015-05-29Clinical Trial Update: Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations [Phase 1]
Phase 1 study evaluating bevacizumab for acute neuromyelitis optica exacerbations; the trial completed and posted results in 2015.
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CLINICAL_TRIALS trial_result · 2014-07-18Clinical Trial Update: C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation [Phase 1]
Phase 1 trial evaluating Cinryze (C1-esterase inhibitor) for acute treatment of an exacerbation in neuromyelitis optica. The study completed…
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CLINICAL_TRIALS trial_result · 2013-12-27Clinical Trial Update: Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders [Phase 4]
Phase 4 trial evaluating the efficacy and safety of mitoxantrone in patients with refractory neuromyelitis optica and related disorders.
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CLINICAL_TRIALS trial_result · 2013-11-04Clinical Trial Update: An Open Label Study of the Effects of Eculizumab in Neuromyelitis Optica [Phase 1, Phase 2]
An open-label Phase 1/2 trial evaluating eculizumab in neuromyelitis optica (Devic's disease) has completed, with results posted in 2013.
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CLINICAL_TRIALS trial_result · 2011-09-27Clinical Trial Update: Safety and Tolerability of Rituximab in Neuromyelitis Optica [Phase 1]
Phase 1 trial evaluating the safety and tolerability of rituximab in patients with Neuromyelitis Optica has been completed.