Neuroblastoma
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EMA withdrawal · 2025-11-14EMA Refused: Kizfizo (temozolomide) — ORPHELIA Pharma
The EMA refused marketing authorization for Kizfizo (temozolomide) for neuroblastoma, in an application from ORPHELIA Pharma.
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CLINICAL_TRIALS withdrawal · 2025-09-10Clinical Trial Update: Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study [Phase 1]
This document reports the withdrawal of a Phase 1 trial evaluating the combination of nivolumab and ipilimumab in pediatric and young adult …
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CLINICAL_TRIALS withdrawal · 2025-01-21Clinical Trial Update: 18F-mFBG Expression in Neural Crest Tumors and Organs Innervated by the Sympathetic Nervous System [Phase 2]
The Phase 2 trial evaluating the radiopharmaceutical 18F-mFBG for neural crest tumors has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2024-12-11Clinical Trial Update: 131I-Metaiodobenzylguanidine (131I-MIBG) Therapy for Relapsed/Refractory Neuroblastoma
This clinical trial evaluating 131I-MIBG therapy for relapsed/refractory neuroblastoma is no longer available; sponsored by UT Southwestern …
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CLINICAL_TRIALS withdrawal · 2024-08-07Clinical Trial Update: Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma [Phase 2]
A Phase 2 trial evaluating defibrotide prophylaxis to prevent transplant-associated thrombotic microangiopathy in neuroblastoma patients has…
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CLINICAL_TRIALS withdrawal · 2024-08-05Clinical Trial Update: PediCARE Health Equity Intervention in High-Risk Neuroblastoma [NA]
The PediCARE health equity trial for high-risk neuroblastoma has been withdrawn. The study was sponsored by Dana-Farber Cancer Institute.
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EMA withdrawal · 2023-06-14EMA Refused: Omblastys (iodine (131I) omburtamab) — Y-Mabs Therapeutics A/S
EMA refused the Omblastys application (iodine-131 omburtamab) for neuroblastoma, leading to no approval at this time.
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CLINICAL_TRIALS withdrawal · 2017-11-24Clinical Trial Update: A Vaccine Study for High Risk Cancers [Phase 1]
A Phase 1 cancer vaccine study has been withdrawn; it targeted neuroblastoma, rhabdomyosarcoma, and osteosarcoma.
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CLINICAL_TRIALS withdrawal · 2017-08-30Clinical Trial Update: A Combined Cell Therapy Approach to the Treatment of Neuroblastoma [Phase 1]
A Phase 1 clinical trial evaluating a combined cell therapy for neuroblastoma has been withdrawn. The sponsor is H. Lee Moffitt Cancer Cente…
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CLINICAL_TRIALS withdrawal · 2017-08-25Clinical Trial Update: Dosimetry Guided PRRT With 90Y-DOTATOC [Phase 2]
A Phase 2 trial evaluating dosimetry-guided peptide receptor radionuclide therapy using 90Y-DOTATOC has been withdrawn. The study covered ne…
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CLINICAL_TRIALS withdrawal · 2017-07-02Clinical Trial Update: A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors [Phase 1]
A Phase I study of pazopanib as a single agent for children with refractory solid tumors has been withdrawn from the trial program.
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CLINICAL_TRIALS withdrawal · 2017-06-14Clinical Trial Update: 3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA [Phase 1]
The Phase 1 trial evaluating third-generation GD2-targeted CAR-NKT cell therapy for neuroblastoma has been withdrawn.
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EMA withdrawal · 2017-04-28EMA Withdrawn: Unituxin (Dinutuximab) — United Therapeutics Europe Ltd
EMA has withdrawn Unituxin (dinutuximab) from the market in Europe.
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CLINICAL_TRIALS withdrawal · 2016-06-21Clinical Trial Update: 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) [Phase 2]
A Phase 2 trial of 90Y DOTA/Retinoic Acid for neuroblastoma and neuroendocrine tumors has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2015-12-03Clinical Trial Update: Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor [Phase 2]
A Phase 2 pediatric trial evaluating chemotherapy followed by peripheral stem cell transplantation for newly diagnosed brain tumors has been…
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CLINICAL_TRIALS withdrawal · 2015-11-26Clinical Trial Update: Efficacy and Safety of Ultratrace™ Iobenguane I 131 in Neuroblastoma [Phase 2]
A Phase 2 clinical trial evaluating Ultratrace Iobenguane I-131 for Neuroblastoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2015-10-16Clinical Trial Update: Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Refractory High-Risk NBL. [Phase 2]
The Phase 2 trial evaluating allogeneic hematopoietic stem cell transplantation for relapsed or refractory high-risk neuroblastoma has been …
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CLINICAL_TRIALS withdrawal · 2015-06-11Clinical Trial Update: New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma [Phase 1, Phase 2]
This clinical trial update notes that the Newcastle Disease Virus (NDV) therapy trial for Glioblastoma, Sarcoma, and Neuroblastoma has been …
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CLINICAL_TRIALS withdrawal · 2014-12-11Clinical Trial Update: Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid Tumors [NA]
This clinical trial update indicates that Vanderbilt University’s study on early enteral tube feedings for children undergoing chemotherapy …
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CLINICAL_TRIALS withdrawal · 2013-12-10Clinical Trial Update: Aflac ST1001 Prolonged Isotretinoin [Phase 1]
A Phase 1 trial of Aflac ST1001 Prolonged Isotretinoin for neuroblastoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2013-07-10Clinical Trial Update: High-Dose Iodine I 131 Metaiodobenzylguanidine, Topotecan, and Peripheral Stem Cell Transplant in Treating Young Patients With Relapsed Stage 4 Neuroblastoma or Primary Resistant High-Risk Neuroblastoma [Phase 2]
A Phase 2 trial evaluating high-dose Iodine-131 metaiodobenzylguanidine (I-131 MIBG), topotecan, and peripheral stem cell transplant in youn…