Neovascular Age-related Macular Degeneration
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Assay of Pro-angiogenic Cytokines in Exudative Age-Related Macular Degeneration [NA]
This update documents a completed clinical study that assays pro-angiogenic cytokines in exudative (neovascular) age-related macular degener…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324 [Phase 1]
A Phase 1b study evaluating safety, tolerability, pharmacokinetics, and exploratory efficacy of intravitreal OLN324 in diabetic macular edem…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) [Phase 3]
Phase 3 trial AQUARIUS is evaluating the efficacy and safety of Ixo-vec (Ixoberogene soroparvovec) in neovascular/wet age-related macular de…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: A Randomized Trial of Pain, Procedure Time, Patient Satisfaction, and Safety [NA]
A randomized trial evaluating speculum-free intravitreal injection using cotton-tipped applicator retraction, assessing pain, procedure time…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration [Phase 1, Phase 2]
EyeBiotech Ltd reports a two-part Phase 1/Phase 2 clinical trial evaluating safety in macular edema due to branch retinal vein occlusion and…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
Hoffmann-La Roche reports a real-world, observational study to gain clinical insights into Roche ophthalmology products across several retin…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: A Study to Learn More About the Use of Aflibercept in Routine Medical Practice in Japanese Participants With Neovascular Age-related Macular Degeneration and Diabetic Macular Edema
Clinical trial update describing the use of aflibercept in routine medical practice for Japanese participants with neovascular age-related m…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Safety and Efficacy Evaluation of LX111 Gene Therapy in nAMD Patients [EARLY_Phase 1]
This clinical trial update outlines a safety and efficacy evaluation of LX111 gene therapy for neovascular age-related macular degeneration,…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Safety and Efficacy of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (VENUS) [Phase 2]
Phase 2 VENUS study evaluating the safety and efficacy of LX102 gene therapy for neovascular age-related macular degeneration; the trial is …
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (STELLAR) [Phase 3]
A Phase 3 clinical trial assessing the efficacy and safety of LX102 Gene Therapy for neovascular age-related macular degeneration (nAMD) is …
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) [Phase 2]
Clinical trial update on Phase 2 RGX-314 gene therapy for neovascular age-related macular degeneration, delivered in the suprachoroidal spac…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participants With Neovascular Age-related Macular Degeneration (nAMD)/Diabetic Macular Edema (DME)
This clinical trial update notes the completion of a study evaluating the conjunctiva and Tenon's capsule status in healthy subjects and in …
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD [Phase 2, Phase 3]
Clinical trial update for ABBV-RGX-314 (RGX-314) gene therapy in neovascular age-related macular degeneration, with Phase 2/Phase 3 pivotal …
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular Degeneration
This clinical trial update describes evaluating switching from 2 mg aflibercept to 8 mg aflibercept in patients with neovascular age-related…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study)
This clinical trial update describes a real-world evidence study evaluating the use of faricimab in diabetic macular edema, neovascular age-…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Intravitreal (IVT) Injection of ABI-110 (AAV2.N54-VEGF Trap) in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (wAMD), Including Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) [Phase 1, Phase 2]
This document describes an ongoing Phase 1/2 clinical trial evaluating the safety, tolerability, and preliminary efficacy of intravitreal AB…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: To Evaluate the Safety, Pharmacokinetics, and Efficacy of GB10 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD) [Phase 1]
This clinical trial update describes a Phase 1 study to evaluate the safety, pharmacokinetics, and efficacy of GB10 injected into the eye fo…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: 4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating 4D-150 for neovascular (wet) age-related macular degeneration is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
This entry provides an update on the OPTIC-EXT long-term extension study of ADVM-022 for wet age-related macular degeneration. The trial is …
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome) [Phase 3]
Phase 3 Velodrome trial update for the Port Delivery System delivering ranibizumab in neovascular age-related macular degeneration; the stud…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration [Phase 1, Phase 2]
Clinical trial update for Zifibancimig in participants with Neovascular Age-Related Macular Degeneration. The Phase 1/2 study is currently a…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration [Phase 4]
Phase 4 clinical trial update assessing efficacy, safety, and durability of Faricimab in neovascular age-related macular degeneration; trial…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD) [Phase 3]
Phase 3 clinical trial evaluating the efficacy, safety, and pharmacokinetics of the Port Delivery System delivering ranibizumab in Chinese p…
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CLINICAL_TRIALS research · 2026-01-29Clinical Trial Update: Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD [Phase 3]
Phase 3 clinical trial comparing home OCT-guided treatment with the treat-and-extend approach for neovascular age-related macular degenerati…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Evaluate the Efficacy of Faricimab in Patients With Neovascular Age-related Macular Degeneration [Phase 4]
A Phase 4 clinical trial update evaluating the efficacy of Faricimab in patients with neovascular age-related macular degeneration; the stud…