Neovascular Age-related Macular Degeneration
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: VEGFA-targeting Gene Therapy to Treat Retinal and Choroidal Neovascularization Diseases [EARLY_Phase 1]
An early-phase clinical trial from Shanghai BDgene is evaluating a VEGFA-targeting gene therapy for neovascular age-related macular degenera…
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME [Phase 2]
Phase 2 study update on the safety, tolerability, and pharmacokinetics of subcutaneous D-4517.2 in participants with neovascular age-related…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Safety and Efficacy Study of IVB103 Injection in Subjects With Neovascular (Wet) Agerelated Macular Degeneration (nAMD). [Phase 1]
A Phase 1 clinical trial evaluating the safety and potential efficacy of IVB103 injection in adults with neovascular age-related macular deg…
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Impact of Intravitreal Faricimab on Renal Function in Diabetic Patients [NA]
Clinical trial update notes ongoing recruitment for a study evaluating the impact of intravitreal Faricimab on renal function in patients wi…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration [Phase 3]
This clinical trial update indicates that Ocular Therapeutix is evaluating intravitreal axitinib implants (OTX-TKI) for neovascular age-rela…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: A Phase 3 Clinical Trial to Compare RBS-001 to Eylea® in Subjects With Neovascular Age-Related Macular Degeneration [Phase 3]
A Phase 3 clinical trial is planned to compare RBS-001 to Eylea for neovascular age-related macular degeneration. The study is currently not…
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CLINICAL_TRIALS research · 2025-03-17Clinical Trial Update: CRISPR/cas13-medIated RNA TarGeting THerapy for the Treatment of Neovascular Age-related Macular Degeneration Investigator-initiated Trial (SIGHT-I) [EARLY_Phase 1]
Investigator-initiated Phase 1 trial evaluating a CRISPR/cas13-mediated RNA targeting therapy for neovascular age-related macular degenerati…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of IBI302 in Subjects With nAMD [Phase 3]
Phase 3 trial evaluating the efficacy and safety of IBI302 in neovascular age-related macular degeneration; the study is currently not recru…
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CLINICAL_TRIALS research · 2025-02-03Clinical Trial Update: Recurrence and Predictive OCT Biomarkers in Quiescent Neovascular AMD
A study update examining recurrence and predictive OCT biomarkers in quiescent neovascular age-related macular degeneration.
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: Regulatory Post-Marketing Surveillance Study for Brolucizumab
Regulatory post-marketing surveillance clinical trial for brolucizumab is recruiting to monitor safety in neovascular age-related macular de…
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CLINICAL_TRIALS research · 2025-01-09Clinical Trial Update: Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD) [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating intravitreal SKG0106 for neovascular age-related macular degeneration is currently recruiting.
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Safety and Tolerability of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD) [Phase 1, Phase 2]
This clinical trial update reports on the safety and tolerability assessment of KH658 gene therapy in subjects with neovascular age-related …
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CLINICAL_TRIALS research · 2024-10-02Clinical Trial Update: Open-laBel Dose-escalation Study for CRISPR/cas13- Rna TargetInG THerapy for the Treatment of Neovascular Age-related Macular Degeneration in Phase I Trial [Phase 1]
Phase I open-label, dose-escalation trial of a CRISPR/Cas13-RNA targeting therapy for neovascular age-related macular degeneration; the stud…
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CLINICAL_TRIALS research · 2024-08-27Clinical Trial Update: Trial to Evaluate the Safety and Efficacy of EB-203 in Patients With Neovascular Age-related Macular Degeneration [Phase 2]
A Phase 2 clinical trial evaluating the safety and efficacy of EB-203 for neovascular age-related macular degeneration is currently recruiti…
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: Gene Therapy(FT-003) for Wet AMD [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating gene therapy FT-003 for neovascular age-related macular degeneration and is currently recruiting.
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CLINICAL_TRIALS research · 2024-06-05Clinical Trial Update: Mechanisms of Retinal Revascularization and Clinical Indicators of Neovascular AMD Relapse
A completed clinical trial update exploring the mechanisms of retinal revascularization and clinical indicators of relapse in neovascular ag…
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CLINICAL_TRIALS research · 2017-10-04Clinical Trial Update: Impact of Home Monitoring to Decrease the Treatment Burden for Neovascular Age-related Macular Degeneration (AMD) [Phase 4]
A Phase 4 trial evaluating home monitoring to reduce treatment burden in neovascular age-related macular degeneration has completed.
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CLINICAL_TRIALS research · 2017-04-26Clinical Trial Update: Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration [NA]
Clinical trial update evaluating visual function and driving ability using Ocusweep in patients with wet age-related macular degeneration.
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CLINICAL_TRIALS research · 2017-03-01Clinical Trial Update: Observation of Treatment Patterns With Lucentis in Approved Indications
An observational study examining how Lucentis is used in approved indications such as neovascular age-related macular degeneration and diabe…
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CLINICAL_TRIALS research · 2015-03-24Clinical Trial Update: FUSION Regimen: Combined Pro re Nata and Fixed Regimen Ranibizumab in Exudative Age-related Macular Degeneration [Phase 4]
Phase 4 clinical trial evaluating a combined pro re nata and fixed dosing regimen of ranibizumab for exudative age-related macular degenerat…
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CLINICAL_TRIALS research · 2012-08-02Clinical Trial Update: VEGF Gene Association With Response to Neovascular Age-related Macular Degeneration With Anti-VEGF Agents
A clinical trial update examines whether VEGF gene variation influences response to anti-VEGF therapy in neovascular age-related macular deg…
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CLINICAL_TRIALS research · 2011-09-27Clinical Trial Update: Study of Intravitreal Microplasmin in Relieving Vitreo-Macular Adhesion in Neovascular Age-related Macular Degeneration [Phase 2]
This entry provides a status update on a Phase 2 clinical trial evaluating intravitreal microplasmin to relieve vitreomacular adhesion in ne…
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CLINICAL_TRIALS research · 2011-07-20Clinical Trial Update: Supplemental Adjuvants for Intracellular Nutrition and Treatment [NA]
A clinical trial update on supplemental adjuvants for intracellular nutrition and treatment in patients with ocular diseases, specifically n…
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CLINICAL_TRIALS research · 2008-06-26Clinical Trial Update: Intravitreal Bevacizumab vs. Bevacizumab Combined With Triamcinolone for Neovascular AMD [Phase 3]
Phase 3 clinical trial comparing intravitreal bevacizumab alone versus bevacizumab with triamcinolone for neovascular age-related macular de…
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CLINICAL_TRIALS research · 2007-04-27Clinical Trial Update: Treatment of Patients With Neovascular AMD Using Indocyanine Green-Mediated Photothrombosis (i-MP). [Phase 2]
Phase 2 trial evaluating indocyanine green–mediated photothrombosis for neovascular age-related macular degeneration.