Neovascular Age-related Macular Degeneration
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Phase I/II Study of PRL3-zumab in Neovascular Age-related Macular Degeneration (nAMD) [Phase 1, Phase 2]
Phase I/II trial update evaluating PRL3-zumab for neovascular age-related macular degeneration; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD [Phase 3]
Phase 3 pivotal study update on RGX-314 gene therapy for neovascular age-related macular degeneration (nAMD), with recruitment ongoing under…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration [Phase 3]
A Phase 3 clinical trial evaluating a single intravitreal injection of 4D-150 for neovascular age-related macular degeneration is currently …
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) [Phase 3]
A Phase 3 clinical trial evaluating the injection burden, adverse events, disease activity, and long-term visual acuity preservation of Sura…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: DATA-INSIGHT is a Project That Looks at Health Data in Germany to Find Out How Many Patients Suffer From Eye Disease. The Project Also Explores New Ways to Collect and Use Publicly Available Healthcare Information.
A Bayer-sponsored clinical trial project in Germany aims to quantify how many patients suffer from major eye diseases and explores new metho…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS) [Phase 4]
A Phase 4 clinical trial is investigating corneal endothelial cell changes in participants with neovascular age-related macular degeneration…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: This is a 96-week, Multicenter Study in Patients With Neovascular AMD That Evaluates OCUL101 for Efficacy, Safety, Durability, and Pharmacokinetics, Comparing it With Another Treatment. The Study Will be Conducted in Two Parts, Part A and Part B. [Phase 2, Phase 3]
This clinical trial update describes a 96-week multicenter Phase 2/3 study of OCUL101 for neovascular age-related macular degeneration, with…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
A real-world study investigating Faricimab (Vabysmo) for neovascular age-related macular degeneration and diabetic macular edema is currentl…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Long-term Follow up Study of EXG102-031 in Patients With wAMD (Everest LTFU) [Phase 1]
Clinical trial update on EXG102-031 long-term follow-up in patients with neovascular age-related macular degeneration (wet AMD); Phase 1 stu…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Study to Evaluate Long-Term Safety of Intravitreal OTX-TKI (Axitinib Implant) in Participants With Neovascular Age-Related Macular Degeneration Who Successfully Completed 2-Year OTX-TKI-2023-AMD-301 or OTX-TKI-2023-AMD-303 Study [Phase 3]
This is a Phase 3 trial extension evaluating the long-term safety of the intravitreal axitinib implant (OTX-TKI) in participants with neovas…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
This is an observational study sponsored by Bayer evaluating how well aflibercept 8 mg works for visual impairment due to neovascular age-re…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD [Phase 3]
Phase 3 study evaluating 36-week refill exchanges of Port Delivery System delivering ranibizumab for neovascular age-related macular degener…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Assay of Pro-angiogenic Cytokines in Exudative Age-Related Macular Degeneration [NA]
This update documents a completed clinical study that assays pro-angiogenic cytokines in exudative (neovascular) age-related macular degener…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) [Phase 3]
Phase 3 trial AQUARIUS is evaluating the efficacy and safety of Ixo-vec (Ixoberogene soroparvovec) in neovascular/wet age-related macular de…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: A Randomized Trial of Pain, Procedure Time, Patient Satisfaction, and Safety [NA]
A randomized trial evaluating speculum-free intravitreal injection using cotton-tipped applicator retraction, assessing pain, procedure time…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration [Phase 1, Phase 2]
EyeBiotech Ltd reports a two-part Phase 1/Phase 2 clinical trial evaluating safety in macular edema due to branch retinal vein occlusion and…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
Hoffmann-La Roche reports a real-world, observational study to gain clinical insights into Roche ophthalmology products across several retin…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: A Study to Learn More About the Use of Aflibercept in Routine Medical Practice in Japanese Participants With Neovascular Age-related Macular Degeneration and Diabetic Macular Edema
Clinical trial update describing the use of aflibercept in routine medical practice for Japanese participants with neovascular age-related m…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Safety and Efficacy Evaluation of LX111 Gene Therapy in nAMD Patients [EARLY_Phase 1]
This clinical trial update outlines a safety and efficacy evaluation of LX111 gene therapy for neovascular age-related macular degeneration,…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (STELLAR) [Phase 3]
A Phase 3 clinical trial assessing the efficacy and safety of LX102 Gene Therapy for neovascular age-related macular degeneration (nAMD) is …
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) [Phase 2]
Clinical trial update on Phase 2 RGX-314 gene therapy for neovascular age-related macular degeneration, delivered in the suprachoroidal spac…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD [Phase 2, Phase 3]
Clinical trial update for ABBV-RGX-314 (RGX-314) gene therapy in neovascular age-related macular degeneration, with Phase 2/Phase 3 pivotal …
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study)
This clinical trial update describes a real-world evidence study evaluating the use of faricimab in diabetic macular edema, neovascular age-…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Intravitreal (IVT) Injection of ABI-110 (AAV2.N54-VEGF Trap) in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (wAMD), Including Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) [Phase 1, Phase 2]
This document describes an ongoing Phase 1/2 clinical trial evaluating the safety, tolerability, and preliminary efficacy of intravitreal AB…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: To Evaluate the Safety, Pharmacokinetics, and Efficacy of GB10 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD) [Phase 1]
This clinical trial update describes a Phase 1 study to evaluate the safety, pharmacokinetics, and efficacy of GB10 injected into the eye fo…