Myelofibrosis
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FDA approval · 2014-05-30FDA Approved: JAKAFI — Supplemental Application (Incyte Corporation)
The FDA approved a supplemental application for JAKAFI (ruxolitinib) submitted by Incyte Corporation, resulting in updated labeling.
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CLINICAL_TRIALS trial_result · 2014-05-21Clinical Trial Update: 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia [Phase 2]
Phase 2 trial evaluating the combination of Triapine (3-AP) and fludarabine in various myeloproliferative disorders and advanced phases of c…
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CLINICAL_TRIALS trial_result · 2014-05-16Clinical Trial Update: Total Body Irradiation With Fludarabine Followed by Combined Umbilical Cord Blood (UCB) Transplants [Phase 1]
Phase 1 trial evaluating total body irradiation with fludarabine followed by combined umbilical cord blood transplants has completed. The tr…
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CLINICAL_TRIALS trial_result · 2014-05-09Clinical Trial Update: CC-4047 in Treating Patients With Myelofibrosis [Phase 1, Phase 2]
Phase 1/2 clinical trial of CC-4047 in patients with chronic myeloproliferative disorders and secondary myelofibrosis has completed with res…
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CLINICAL_TRIALS trial_result · 2014-03-14Clinical Trial Update: Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence [Phase 3]
Phase 3 trial of pomalidomide in myeloproliferative neoplasm-associated myelofibrosis and RBC-transfusion-dependence completed in 2014.
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CLINICAL_TRIALS trial_result · 2014-03-05Clinical Trial Update: Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases [Phase 3]
Phase 3 trial comparing sibling donor peripheral blood stem cell transplant versus sibling donor bone marrow transplant in hematologic disea…
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CLINICAL_TRIALS trial_result · 2014-02-25Clinical Trial Update: Imatinib Mesylate in Treating Patients With Myelofibrosis [Phase 2]
Phase 2 clinical trial evaluating Imatinib Mesylate in patients with myelofibrosis has completed. The study also addresses related myeloprol…
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CLINICAL_TRIALS trial_result · 2014-01-30Clinical Trial Update: Study of SB939 in Subjects With Myelofibrosis [Phase 2]
Phase 2 study of the investigational drug SB939 in patients with myelofibrosis has completed, with results posted in January 2014.
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CLINICAL_TRIALS trial_result · 2013-10-28Clinical Trial Update: A Phase II Study of Pomalidomide in Myelofibrosis With Myeloid Metaplasia [Phase 2]
Phase II study evaluating pomalidomide in myelofibrosis with myeloid metaplasia completed with results posted in 2013.
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CLINICAL_TRIALS trial_result · 2013-10-08Clinical Trial Update: Thalidomide in Treating Patients With Myelofibrosis [Phase 2]
A Phase 2 clinical trial evaluating thalidomide for primary myelofibrosis has completed.
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CLINICAL_TRIALS trial_result · 2013-09-26Clinical Trial Update: Lenalidomide and Prednisone in Treating Patients With Myelofibrosis [Phase 2]
This Phase 2 trial evaluated lenalidomide in combination with prednisone for patients with myelofibrosis and related myeloproliferative neop…
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CLINICAL_TRIALS trial_result · 2013-09-25Clinical Trial Update: Study of Ruxolitinib (INCB018424) Sustained Release Formulation in Myelofibrosis Patients [Phase 2]
This clinical trial update reports results from a Phase 2 study of a sustained-release formulation of ruxolitinib in myelofibrosis, with res…
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CLINICAL_TRIALS trial_result · 2013-08-26Clinical Trial Update: Safety and Efficacy of Obatoclax Mesylate (GX15-070MS) in the Treatment of Myelofibrosis With Myeloid Metaplasia [Phase 2]
A Phase 2 trial assessing the safety and efficacy of Obatoclax Mesylate (GX15-070MS) in patients with myelofibrosis (myelofibrosis with myel…
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CLINICAL_TRIALS trial_result · 2013-06-17Clinical Trial Update: Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs
This clinical trial update reports on plasma vitamin and homocysteine levels and thrombosis in patients with Philadelphia-negative myeloprol…
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FDA approval · 2013-06-12FDA Approved: JAKAFI — Supplemental Application (Incyte Corporation)
The FDA approved a supplemental application for JAKAFI (ruxolitinib) submitted by Incyte Corporation.
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CLINICAL_TRIALS trial_result · 2013-06-04Clinical Trial Update: Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia [Phase 2]
Phase 2 clinical trial update on tipifarnib for myelofibrosis and related myeloproliferative disorders, with the study having completed.
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CLINICAL_TRIALS research · 2013-03-21Clinical Trial Update: Myeloproliferative Neoplasms and Bone Structure
This is a clinical trial update on myeloproliferative neoplasms and bone structure. The current status of the study is unknown.
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CLINICAL_TRIALS trial_result · 2012-12-07Clinical Trial Update: Study of Parathyroid Hormone Following Sequential Cord Blood Transplantation From an Unrelated Donor [Phase 2]
Phase 2 study evaluating parathyroid hormone after sequential cord blood transplantation from an unrelated donor; the trial was terminated a…
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CLINICAL_TRIALS trial_result · 2012-11-15Clinical Trial Update: A Phase 2 Study With IPI-926 in Patients With Myelofibrosis [Phase 2]
This entry notes the completion of a Phase 2 study of IPI-926 (saridegib) in patients with primary myelofibrosis.
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CLINICAL_TRIALS trial_result · 2012-08-14Clinical Trial Update: Sunitinib in Treating Patients With Idiopathic Myelofibrosis [Phase 2]
Phase 2 trial of sunitinib in patients with primary myelofibrosis was terminated; results were posted in 2012.
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CLINICAL_TRIALS trial_result · 2012-08-02Clinical Trial Update: Open Label Ruxolitinib (INCB018424) in Patients With Myelofibrosis and Post Polycythemia Vera/Essential Thrombocythemia Myelofibrosis [Phase 1, Phase 2]
Open-label Phase 1/2 trial results for ruxolitinib (INCB018424) in patients with myelofibrosis, including those with post-polycythemia vera/…
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FDA approval · 2012-06-21FDA Approved: JAKAFI — Supplemental Application (Incyte Corporation)
The FDA approved a supplemental application for JAKAFI (ruxolitinib) submitted by Incyte Corporation.
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CLINICAL_TRIALS trial_result · 2012-06-12Clinical Trial Update: Bone Marrow Transplantation in Treating Patients With Multiple Myeloma, Chronic Phase Chronic Myelogenous Leukemia, or Agnogenic Myeloid Metaplasia [Phase 2]
Phase 2 clinical trial update on bone marrow transplantation for patients with multiple myeloma, chronic myeloid leukemia (chronic phase), o…
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CLINICAL_TRIALS trial_result · 2012-05-30Clinical Trial Update: Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II: The COMFORT-II Trial [Phase 3]
Phase 3 COMFORT-II trial evaluating a JAK inhibitor for myelofibrosis has completed with posted results.
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CLINICAL_TRIALS withdrawal · 2012-05-10Clinical Trial Update: Palifermin After Haploidentical PBSCT [Phase 2]
A Phase 2 trial evaluating palifermin after haploidentical peripheral blood stem cell transplantation has been withdrawn.