Myelofibrosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2019-02-04Clinical Trial Update: Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET) [Phase 2]
This is a Phase 2 extension study evaluating the long-term safety and efficacy of CYT387 (momelotinib) in patients with primary myelofibrosi…
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CLINICAL_TRIALS trial_result · 2019-02-04Clinical Trial Update: Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis [Phase 1, Phase 2]
A Phase 1/2 safety study evaluating twice-daily momelotinib in myelofibrosis populations has completed.
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CLINICAL_TRIALS trial_result · 2019-02-01Clinical Trial Update: Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET) [Phase 1, Phase 2]
This update reports the completion of a Phase 1/2 safety and efficacy study of CYT387 in primary myelofibrosis and myelofibrosis following p…
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CLINICAL_TRIALS trial_result · 2018-12-24Clinical Trial Update: Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States [Phase 2]
Phase 2 trial investigating reduced-intensity allogeneic peripheral blood stem cell transplantation for hematologic malignancies and hematop…
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CLINICAL_TRIALS trial_result · 2018-12-04Clinical Trial Update: Allogeneic Stem Cell Transplantation for Myelofibrosis and Myelodysplastic Syndrome [Phase 2]
Phase 2 clinical trial update on allogeneic stem cell transplantation for myelofibrosis (and related myelodysplastic syndromes) completed wi…
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CLINICAL_TRIALS trial_result · 2018-07-24Clinical Trial Update: Pegylated Interferon Alpha-2b in Early Primary Myelofibrosis [Phase 2]
Phase 2 study of pegylated interferon alpha-2b in early primary myelofibrosis; the trial was terminated and results were posted.
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Vismodegib in Combination With Ruxolitinib for the Treatment of Intermediate- or High-Risk Myelofibrosis (MF) [Phase 1]
This update notes the completion of a Phase 1 study evaluating vismodegib in combination with ruxolitinib for intermediate- or high-risk mye…
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CLINICAL_TRIALS trial_result · 2018-04-17Clinical Trial Update: A Study in Myeloproliferative Disorders [Phase 1]
Phase 1 study in myeloproliferative neoplasms has completed, evaluating patients with essential thrombocythemia, polycythemia vera, and prim…
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CLINICAL_TRIALS trial_result · 2018-04-03Clinical Trial Update: Busulfan, Cyclophosphamide, & Antithymocyte Globulin Followed by Stem Cell Transplant in Treating Hematologic Cancer [Phase 2]
Phase 2 clinical trial evaluating busulfan, cyclophosphamide, and antithymocyte globulin followed by stem cell transplant for hematologic ca…
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CLINICAL_TRIALS trial_result · 2018-04-02Clinical Trial Update: Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib [Phase 2]
A Phase 2 trial of single-agent glasdegib in myelofibrosis patients previously treated with ruxolitinib was terminated; results were posted …
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CLINICAL_TRIALS trial_result · 2018-01-02Clinical Trial Update: Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome [NA]
Clinical trial update on cyclophosphamide and busulfan followed by donor stem cell transplant for myelofibrosis, AML, or myelodysplastic syn…
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CLINICAL_TRIALS trial_result · 2017-12-02Clinical Trial Update: Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases [Phase 1]
Phase 1 trial evaluating the safety of Umbilical Cord Blood T-Regulatory Cell infusion followed by donor cord blood transplant in patients w…
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CLINICAL_TRIALS trial_result · 2017-10-18Clinical Trial Update: Ruxolitinib Phosphate and Danazol in Treating Anemia in Patients With Myelofibrosis [Phase 2]
Phase 2 trial evaluating the combination of ruxolitinib phosphate and danazol to treat anemia in patients with primary or secondary myelofib…
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CLINICAL_TRIALS research · 2017-07-02Clinical Trial Update: Molecular Changes and Biomarkers in Chronic Myeloproliferative Disorders
A completed NIH-backed clinical trial examining molecular changes and biomarkers in chronic myeloproliferative disorders including polycythe…
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies [NA]
Clinical trial update for fludarabine-based conditioning prior to allogeneic transplantation in advanced hematologic malignancies; study com…
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EMA withdrawal · 2017-06-09EMA Application withdrawn: Enpaxiq — CTI Life Sciences Limited
The EMA withdrawn the application for Enpaxiq by CTI Life Sciences Limited, with the primary indication in myelofibrosis.
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions in Treating Patients With Hematologic Cancer or Other Diseases [Phase 2]
Phase 2 study evaluating T-cell depletion and donor hematopoietic stem cell transplantation with T-cell infusions in patients with various h…
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CLINICAL_TRIALS withdrawal · 2017-05-08Clinical Trial Update: Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) [Phase 1]
A Phase 1 trial evaluating pacritinib in combination with low-dose decitabine for intermediate-high risk myelofibrosis and related myeloprol…
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CLINICAL_TRIALS trial_result · 2017-04-24Clinical Trial Update: Study to Assess the Safety of AZD1480 in Patients With Myeloproliferative Diseases [Phase 1]
A Phase 1 trial evaluating the safety of AZD1480 in adults with myeloproliferative diseases has completed, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-04-12Clinical Trial Update: Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms [Phase 1]
Phase 1 study of LY2784544 testing alternative dosing in patients with myeloproliferative neoplasms, including polycythemia vera, essential …
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CLINICAL_TRIALS trial_result · 2017-03-03Clinical Trial Update: Pilot Trial of Arsenic + Cytarabine in Patients With Myelofibrosis [EARLY_Phase 1]
This update reports the completion of an early-phase pilot trial testing arsenic trioxide in combination with cytarabine for myelofibrosis.
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CLINICAL_TRIALS trial_result · 2017-02-10Clinical Trial Update: Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological Disorders [Phase 1, Phase 2]
A completed Phase 1/2 study from Singapore General Hospital evaluated a Traditional Chinese Medicine formulation for supportive management o…
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CLINICAL_TRIALS trial_result · 2016-12-23Clinical Trial Update: A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML) [Phase 2]
Phase 2 study evaluating imatinib (Gleevec) in patients with myelofibrosis and chronic myelomonocytic leukemia has completed. The study was …
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CLINICAL_TRIALS withdrawal · 2016-10-24Clinical Trial Update: Siltuximab in Treating Patients With Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis [EARLY_Phase 1]
Northwestern University’s early-phase trial of siltuximab for myelofibrosis, including primary, post-polycythemia vera, and post-essential t…
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CLINICAL_TRIALS withdrawal · 2016-09-14Clinical Trial Update: Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis [Phase 1]
This Phase 1 trial of a combination of ruxolitinib phosphate, tacrolimus, and sirolimus to prevent acute graft-versus-host disease in patien…