Myelodysplastic Syndromes
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-12-02Clinical Trial Update: T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer [Phase 1]
Phase 1 clinical trial evaluating infusion of regulatory T cells after umbilical cord blood transplant in patients with advanced hematologic…
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CLINICAL_TRIALS trial_result · 2017-11-30Clinical Trial Update: Pilot and Feasibility Study of Reduced-Intensity Hematopoietic Stem Cell Transplant for MonoMAC [Phase 2]
Phase 2 pilot/feasibility study evaluating reduced-intensity hematopoietic stem cell transplant for MonoMAC syndrome.
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Combination Chemotherapy and Total-Body Irradiation Before Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer, Metastatic Breast Cancer, or Kidney Cancer [Phase 1, Phase 2]
A Phase 1/2 trial update on using combination chemotherapy and total-body irradiation before donor umbilical cord blood transplant in patien…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant [Phase 1]
A Phase 1 trial evaluating donor T cells in high-risk hematologic cancers undergoing donor peripheral blood stem cell transplant was termina…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer [NA]
ClinicalTrials.gov entry describes termination of a study evaluating donor umbilical cord blood transplantation for various hematologic canc…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 in Treating Patients With Advanced Leukemia [Phase 1]
The update reports termination of a Phase 1 trial evaluating AHN-12, a Yttrium-90 labeled anti-CD45 monoclonal antibody, in advanced leukemi…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia [NA]
The document reports the completion of a clinical trial evaluating donor lymphocyte infusion for relapsed leukemia after transplantation acr…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Chemotherapy and Total-Body Irradiation Followed by Donor Umbilical Cord Blood Transplant, Cyclosporine, and Mycophenolate Mofetil in Treating Patients With Hematologic Cancer [NA]
This clinical trial update reports completion of a study evaluating chemotherapy and total-body irradiation followed by donor umbilical cord…
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CLINICAL_TRIALS trial_result · 2017-11-20Clinical Trial Update: ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies [Phase 1]
A Phase 1 trial evaluated ABT-348 as a standalone therapy and in combination with azacitidine for advanced hematologic malignancies; the stu…
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CLINICAL_TRIALS trial_result · 2017-11-17Clinical Trial Update: Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes [NA]
This clinical trial evaluated a combination of idarubicin, cytarabine, and pravastatin sodium in adults with acute myeloid leukemia or myelo…
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CLINICAL_TRIALS trial_result · 2017-11-13Clinical Trial Update: Eltrombopag Treatment of Thrombocytopenia in Subjects With Advanced Myelodysplastic Syndrome (MDS) or Secondary Acute Myeloid Leukemia After MDS (sAML/MDS) [Phase 1]
A completed Phase 1 trial evaluating eltrombopag for treating thrombocytopenia in patients with advanced myelodysplastic syndromes or second…
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CLINICAL_TRIALS research · 2017-11-08Clinical Trial Update: Myelodysplastic Syndrome--CDA-2 Hematological Improvement National Affirmation Study [Phase 4]
This is a Phase 4 clinical trial update for Myelodysplastic Syndromes evaluating CDA-2 hematologic improvement in a national study. The stat…
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CLINICAL_TRIALS research · 2017-11-08Clinical Trial Update: A Clinical Trial Evaluating the Efficacy of Ultra Low Dose of Decitabine in Myelodysplastic Syndromes (MDS) [NA]
A clinical trial is evaluating the efficacy of ultra-low-dose decitabine in myelodysplastic syndromes, with no current status reported.
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CLINICAL_TRIALS trial_result · 2017-10-12Clinical Trial Update: Low-Dose Fludarabine, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer [Phase 1]
Phase 1 study evaluating low-dose fludarabine, busulfan, and anti-thymocyte globulin conditioning followed by donor umbilical cord blood tra…
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FDA approval · 2017-09-22FDA Approved: DECITABINE — Original Application (Amneal Pharmaceuticals LLC)
FDA approved Amneal's original ANDA for decitabine, a generic chemotherapy agent. It is indicated for the treatment of myelodysplastic syndr…
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CLINICAL_TRIALS trial_result · 2017-09-15Clinical Trial Update: Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT [Phase 2]
Phase 2 trial evaluating abatacept-based immunosuppression to prevent acute graft-versus-host disease during unrelated donor hematopoietic c…
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CLINICAL_TRIALS withdrawal · 2017-08-31Clinical Trial Update: iCare3: Monitoring Circulating Cancer DNA After Chemotherapy in MDS and AML
A clinical trial (NCT03138395) investigating monitoring circulating cancer DNA after chemotherapy in Acute myeloid leukemia and Myelodysplas…
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CLINICAL_TRIALS trial_result · 2017-08-22Clinical Trial Update: Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic Anemias [Phase 2]
Phase 2 study of deferasirox for iron overload in beta-thalassemia patients who cannot be treated with deferoxamine, as well as related chro…
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CLINICAL_TRIALS trial_result · 2017-08-22Clinical Trial Update: Azacytidine and Bortezomib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes [Phase 1]
Phase 1 study of azacitidine plus bortezomib in relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes has completed enr…
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CLINICAL_TRIALS trial_result · 2017-08-18Clinical Trial Update: Bendamustine and Idarubicin in Treating Older Patients With Previously Untreated AML or MDS [Phase 1, Phase 2]
This clinical trial update describes the Phase 1/2 results for the combination of bendamustine and idarubicin in older patients with previou…
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CLINICAL_TRIALS trial_result · 2017-08-08Clinical Trial Update: A Phase I Clinical Trial of OXi4503 for Relapsed and Refractory AML and MDS [Phase 1]
Phase I trial of OXi4503 for relapsed and refractory acute myeloid leukemia and myelodysplastic syndromes was terminated.
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CLINICAL_TRIALS trial_result · 2017-07-26Clinical Trial Update: A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
Completed clinical trial evaluating whether the final Geriatric Assessment in Haematology (GAH) score can predict tolerance to treatment in …
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CLINICAL_TRIALS trial_result · 2017-07-24Clinical Trial Update: Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome [Phase 4]
This Phase 4 trial compares posaconazole to micafungin for preventing invasive fungal infections during neutropenia in patients receiving ch…
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CLINICAL_TRIALS trial_result · 2017-07-19Clinical Trial Update: Allogeneic Stem Cell Transplant With Clofarabine, Busulfan and Antithymocyte Globulin (ATG) for Adult Patients With High-risk Acute Myeloid Leukemia/Myelodysplastic Syndromes (AML/MDS) or Acute Lymphoblastic Leukemia (ALL) [Phase 2]
Phase 2 trial evaluating an allogeneic stem cell transplant regimen combining clofarabine, busulfan, and antithymocyte globulin in adults wi…
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CLINICAL_TRIALS trial_result · 2017-07-17Clinical Trial Update: PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome (CPKC412A2104 Core); and PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome With Either Wild Type or Mutated FMS-like Tyrosine Kinase 3 (FLT3) (CPKC412A2104E1 and CPKC412A2104E2) [Phase 1, Phase 2]
This clinical trial update reports the completion and posted results of Phase 1 and Phase 2 studies of PKC412 (midostaurin) in adults with a…