Myelodysplastic Syndromes
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: TPO-Mimetic Use in Children for Hematopoietic Failure [EARLY_Phase 1]
An early-phase 1 pediatric trial evaluating thrombopoietin mimetics for hematopoietic failure has completed. The study enrolled children wit…
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CLINICAL_TRIALS trial_result · 2024-07-29Clinical Trial Update: Extension Study to Evaluate Long-Term Effects of Luspatercept in Patients With Myelodysplastic Syndromes (MDS) (A536-05/MK-6143-003) [Phase 2]
Extension Phase 2 study assessing long-term safety and effects of luspatercept in myelodysplastic syndromes has completed; results were post…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression [Phase 3]
Phase 3 trial evaluating haploidentical allogeneic peripheral blood transplantation with analysis of checkpoint immune regulator expression;…
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CLINICAL_TRIALS research · 2024-07-22Clinical Trial Update: Intensive Conditioning withTHI/Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement
This clinical trial is testing an intensive conditioning regimen consisting of Thiotepa, Busulfan, Fludarabine, and Cytarabine followed by a…
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CLINICAL_TRIALS trial_result · 2024-07-19Clinical Trial Update: Safety and Efficacy of Allogeneic NK Cell Infusions in Patients With Relapsed/Refractory AML and High Risk MDS [Phase 1]
Phase 1 trial assessing safety and potential efficacy of allogeneic NK cell infusions in adults with relapsed/refractory acute myeloid leuke…
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: Use of T-allo10 in Hematopoietic Stem Cell Transplantation (HSCT) for Blood Disorders [Phase 1]
Phase 1 trial update on T-allo10 for hematopoietic stem cell transplantation in various blood disorders; the NCT03198234 study sponsored by …
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CLINICAL_TRIALS trial_result · 2024-07-12Clinical Trial Update: Study to Evaluate Additional Risk Minimisation Measures (aRMMs) for REBLOZYL Among Healthcare Professionals (HCPs)
A completed clinical trial evaluated additional risk minimisation measures for REBLOZYL among healthcare professionals.
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide [Phase 2]
Phase 2 haploidentical stem cell transplantation trial using post-transplant cyclophosphamide was terminated.
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Immunophenotyping of Blood Cells in the Diagnosis Work-up of Myelodysplastic Syndromes
A clinical trial is evaluating immunophenotyping of blood cells to assist in the diagnostic work-up of myelodysplastic syndromes and is curr…
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML [Phase 3]
Phase 3 study comparing ASTX727 (cedazuridine/decitabine) versus intravenous decitabine in myelodysplastic syndromes, chronic myelomonocytic…
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FDA approval · 2024-06-28FDA Approved: VIDAZA — Supplemental Application (Celgene Corporation)
The FDA approved a supplemental application for Vidaza (azacitidine) filed by Celgene Corporation.
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CLINICAL_TRIALS trial_result · 2024-06-27Clinical Trial Update: BeFluBu vs FluBuRux Conditioning in Haploidentical HCT [Phase 2]
Phase 2 clinical trial comparing BeFluBu vs FluBuRux conditioning regimens in haploidentical stem cell transplantation is currently recruiti…
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CLINICAL_TRIALS trial_result · 2024-06-26Clinical Trial Update: A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve [Phase 3]
This Phase 3 trial compares luspatercept against epoetin alfa for treating anemia in ESA-naïve patients with IPSS-R very low/low/intermediat…
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CLINICAL_TRIALS other · 2024-06-24Clinical Trial Update: Expanded Access for Treatment With Imetelstat
Expanded access update for imetelstat in myelodysplastic syndromes with status listed as approved for marketing.
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Peri-Transfusion QOL Assessments (PTQA): A New Paradigm of Transfusion Decision Support for Patients With MDS [NA]
A completed trial evaluating peri-transfusion quality-of-life assessments to support transfusion decisions in myelodysplastic syndromes. The…
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CLINICAL_TRIALS research · 2024-06-17Clinical Trial Update: ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML [Phase 1]
Clinical trial update for ACHIEVE2 reports safety and preliminary efficacy data for intravenous TCB008 in patients with relapse or refractor…
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CLINICAL_TRIALS withdrawal · 2024-06-14Clinical Trial Update: Adding Venetoclax to the High-dose Chemotherapy Regimen Prior to Mismatche Allogeneic Stem Cell Transplant [Phase 2]
A Phase 2 trial evaluating adding venetoclax to high-dose chemotherapy before a mismatched allogeneic stem cell transplant for acute myeloid…
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS [Phase 1]
Phase I clinical trial update from Arcellx evaluating cell therapies for relapsed or refractory acute myeloid leukemia and high-risk myelody…
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: BMS-986253 in Myelodysplastic Syndromes [Phase 1, Phase 2]
The clinical trial update reports a terminated Phase 1/2 study of BMS-986253 in myelodysplastic syndromes with results posted on 2024-06-11.
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CLINICAL_TRIALS trial_result · 2024-05-28Clinical Trial Update: Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486 [Phase 2]
A Phase 2 trial completed evaluating in vivo azacitidine incorporation in mononuclear cells after Vidaza or CC-486 treatment in patients wit…
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CLINICAL_TRIALS trial_result · 2024-05-22Clinical Trial Update: Maintenance Low Dose 5'-Azacitidine Post T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Myelodysplastic Syndrome and Acute Myelogenous Leukemia With High Risk for Post-Transplant Relapse [Phase 2]
Phase 2 trial evaluating maintenance low-dose azacitidine after T cell–depleted allogeneic stem cell transplantation in high-risk myelodyspl…
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: IGF-MTX Conjugate in the Treatment of Myelodysplastic Syndrome [Phase 1, Phase 2]
Phase 1/2 clinical trial of IGF-MTX Conjugate for myelodysplastic syndromes and related hematologic conditions has been terminated, with res…
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CLINICAL_TRIALS trial_result · 2024-05-20Clinical Trial Update: Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes [Phase 1, Phase 2]
Phase 1/2 study evaluating decitabine in combination with tretinoin in patients with myelodysplastic syndromes has completed and results hav…
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: A Study of ONO-7475 in Patients With Acute Leukemias [Phase 1, Phase 2]
This clinical trial update reports results from a Phase 1/2 study of ONO-7475 in patients with acute leukemia and myelodysplastic syndromes,…
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FDA approval · 2024-05-16FDA Approved: AZACITIDINE — Original Application (Sandoz Inc)
FDA approved Sandoz Inc.'s generic azacitidine (AZACITIDINE) as an Original Application under ANDA212580.