Myelodysplastic Syndromes
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS [Phase 1]
This Clinical Trial Update reports that a Phase 1 study of CYC065 in combination with Venetoclax for relapsed or refractory acute myeloid le…
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems [Phase 1]
Takeda announced results from a Phase 1 study of pevonedistat in people with blood cancers and solid tumors who also have kidney or liver im…
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CLINICAL_TRIALS trial_result · 2024-08-29Clinical Trial Update: MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies [Phase 2]
Phase 2 study evaluating MGTA-145 in combination with Plerixafor for mobilizing hematopoietic stem cells for allogeneic transplantation in h…
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CLINICAL_TRIALS trial_result · 2024-08-23Clinical Trial Update: Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis [Phase 2, Phase 3]
Phase 2/Phase 3 trial evaluating a combination of post-transplant cyclophosphamide, abatacept, vedolizumab, and baricitinib to prevent graft…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Study of CFI-400945 Fumarate in Patients With Relapsed or Refractory AML or MDS [Phase 1]
Phase 1 trial of CFI-400945 fumarate in relapsed or refractory acute myeloid leukemia and myelodysplastic syndromes has completed.
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: Treatment of Anemia in Patients With Very Low, Low or Intermediate Risk Myelodysplastic Syndromes With CA-4948 [Phase 2]
The Phase 2 study of CA-4948 for treating anemia in patients with very low, low or intermediate risk myelodysplastic syndromes has been term…
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CLINICAL_TRIALS trial_result · 2024-08-02Clinical Trial Update: Effect of Food on Blood Levels of ASTX727 [Phase 1]
Phase 1 trial evaluating the impact of food on plasma levels of ASTX727 (decitabine/cedazuridine) in patients with myelodysplastic syndromes…
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CLINICAL_TRIALS trial_result · 2024-08-02Clinical Trial Update: Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias [Phase 1, Phase 2]
An early-phase study of escalating doses of AT9283 for various leukemias has been terminated.
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CLINICAL_TRIALS trial_result · 2024-08-02Clinical Trial Update: Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome Low Risk [NA]
Clinical trial evaluating allogeneic hematopoietic stem cell transplantation in patients with low-risk myelodysplastic syndromes has complet…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Tipifarnib in Subjects With Myelodysplastic Syndromes [Phase 2]
A Phase 2 trial of tipifarnib for myelodysplastic syndromes was terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: A Phase 1 Study of AMG 330 in Subjects With Myeloid Malignancies [Phase 1]
Phase 1 study of AMG 330 in adults with myeloid malignancies, including relapsed/refractory acute myeloid leukemia and MRD-positive AML, has…
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: TPO-Mimetic Use in Children for Hematopoietic Failure [EARLY_Phase 1]
An early-phase 1 pediatric trial evaluating thrombopoietin mimetics for hematopoietic failure has completed. The study enrolled children wit…
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CLINICAL_TRIALS trial_result · 2024-07-29Clinical Trial Update: Extension Study to Evaluate Long-Term Effects of Luspatercept in Patients With Myelodysplastic Syndromes (MDS) (A536-05/MK-6143-003) [Phase 2]
Extension Phase 2 study assessing long-term safety and effects of luspatercept in myelodysplastic syndromes has completed; results were post…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression [Phase 3]
Phase 3 trial evaluating haploidentical allogeneic peripheral blood transplantation with analysis of checkpoint immune regulator expression;…
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CLINICAL_TRIALS trial_result · 2024-07-19Clinical Trial Update: Safety and Efficacy of Allogeneic NK Cell Infusions in Patients With Relapsed/Refractory AML and High Risk MDS [Phase 1]
Phase 1 trial assessing safety and potential efficacy of allogeneic NK cell infusions in adults with relapsed/refractory acute myeloid leuke…
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: Use of T-allo10 in Hematopoietic Stem Cell Transplantation (HSCT) for Blood Disorders [Phase 1]
Phase 1 trial update on T-allo10 for hematopoietic stem cell transplantation in various blood disorders; the NCT03198234 study sponsored by …
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CLINICAL_TRIALS trial_result · 2024-07-12Clinical Trial Update: Study to Evaluate Additional Risk Minimisation Measures (aRMMs) for REBLOZYL Among Healthcare Professionals (HCPs)
A completed clinical trial evaluated additional risk minimisation measures for REBLOZYL among healthcare professionals.
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide [Phase 2]
Phase 2 haploidentical stem cell transplantation trial using post-transplant cyclophosphamide was terminated.
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML [Phase 3]
Phase 3 study comparing ASTX727 (cedazuridine/decitabine) versus intravenous decitabine in myelodysplastic syndromes, chronic myelomonocytic…
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CLINICAL_TRIALS trial_result · 2024-06-27Clinical Trial Update: BeFluBu vs FluBuRux Conditioning in Haploidentical HCT [Phase 2]
Phase 2 clinical trial comparing BeFluBu vs FluBuRux conditioning regimens in haploidentical stem cell transplantation is currently recruiti…
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CLINICAL_TRIALS trial_result · 2024-06-26Clinical Trial Update: A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve [Phase 3]
This Phase 3 trial compares luspatercept against epoetin alfa for treating anemia in ESA-naïve patients with IPSS-R very low/low/intermediat…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Peri-Transfusion QOL Assessments (PTQA): A New Paradigm of Transfusion Decision Support for Patients With MDS [NA]
A completed trial evaluating peri-transfusion quality-of-life assessments to support transfusion decisions in myelodysplastic syndromes. The…
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS [Phase 1]
Phase I clinical trial update from Arcellx evaluating cell therapies for relapsed or refractory acute myeloid leukemia and high-risk myelody…
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: BMS-986253 in Myelodysplastic Syndromes [Phase 1, Phase 2]
The clinical trial update reports a terminated Phase 1/2 study of BMS-986253 in myelodysplastic syndromes with results posted on 2024-06-11.
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CLINICAL_TRIALS trial_result · 2024-05-28Clinical Trial Update: Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486 [Phase 2]
A Phase 2 trial completed evaluating in vivo azacitidine incorporation in mononuclear cells after Vidaza or CC-486 treatment in patients wit…