Myelodysplastic Syndromes

CLINICAL_TRIALS trial_result · 2015-12-23

Clinical Trial Update: T-cell Depleted Bone Marrow and G-CSF Stimulated Peripheral Stem Cell Transplantation From Related Donors in Treating Patients With Leukemia, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, or Aplastic Anemia [Phase 2]

Phase 2 clinical trial update evaluating T-cell-depleted bone marrow and G-CSF-stimulated peripheral stem cell transplantation from related …

CLINICAL_TRIALS trial_result · 2015-12-22

Clinical Trial Update: Total-Body Irradiation and Chemotherapy Followed By Donor Bone Marrow Transplant in Treating Young Patients With Hematologic Cancer [Phase 2]

Phase 2 trial evaluates total-body irradiation and chemotherapy followed by donor bone marrow transplant in young patients with hematologic …

CLINICAL_TRIALS trial_result · 2015-12-15

Clinical Trial Update: A Study of Vismodegib in Patients With Relapsed/Refractory Acute Myelogenous Leukemia and Relapsed Refractory High-Risk Myelodysplastic Syndrome [Phase 2]

Phase 2 study of vismodegib in relapsed/refractory acute myeloid leukemia and relapsed/refractory high-risk myelodysplastic syndrome was ter…

CLINICAL_TRIALS trial_result · 2015-12-04

Clinical Trial Update: GTI-2040 in Treating Patients With Relapsed, Refractory, or High-Risk Acute Leukemia, High-Grade Myelodysplastic Syndromes, or Refractory or Blastic Phase Chronic Myelogenous Leukemia [Phase 1]

Completed Phase 1 trial of GTI-2040 in adults with relapsed or high-risk acute leukemias, myelodysplastic syndromes, or refractory/blastic p…

CLINICAL_TRIALS trial_result · 2015-12-02

Clinical Trial Update: Safety & Pharmacokinetics of Pegolsihematide for Treatment of Anemia Patient With Myelodysplastic Syndromes [Phase 1]

Phase 1 study assessing the safety and pharmacokinetics of Pegolsihematide in patients with myelodysplastic syndromes and related anemia is …

CLINICAL_TRIALS trial_result · 2015-11-13

Clinical Trial Update: Non-interventional Study With Azacitidin (Vidaza®)

This document reports a completed non-interventional study of azacitidine (Vidaza) in patients with myelodysplastic syndromes, acute myeloid…

CLINICAL_TRIALS trial_result · 2015-11-10

Clinical Trial Update: Donor Umbilical Cord Blood Transplant After Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Cancer [Phase 1, Phase 2]

Phase 1/2 trial evaluating donor umbilical cord blood transplant after fludarabine phosphate, cyclophosphamide, and total-body irradiation i…

CLINICAL_TRIALS trial_result · 2015-09-18

Clinical Trial Update: Oral Clofarabine Study in Patients With Myelodysplastic Syndrome [Phase 2]

Phase 2 trial of oral clofarabine in patients with myelodysplastic syndrome and chronic myelomonocytic leukemia has completed; results were …

CLINICAL_TRIALS trial_result · 2015-08-25

Clinical Trial Update: MK0457 in Patients With Leukemia (0457-003) [Phase 1]

Phase 1 trial update for MK-0457 (VX-680) in leukemia patients has completed; the study included chronic myeloid leukemia in blast crisis, a…

CLINICAL_TRIALS trial_result · 2015-08-24

Clinical Trial Update: Fludarabine, Cyclophosphamide, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer [Phase 2]

Phase 2 trial evaluating a conditioning regimen of fludarabine, cyclophosphamide, and total-body irradiation for patients undergoing donor b…

CLINICAL_TRIALS trial_result · 2015-08-19

Clinical Trial Update: Study of AP23573 in Patients With Relapsed or Refractory Hematologic Malignancies (8669-024)(COMPLETED) [Phase 2]

Completed Phase 2 study of AP23573 (ridaforolimus) in patients with relapsed or refractory hematologic malignancies, including leukemia, mye…

CLINICAL_TRIALS trial_result · 2015-08-17

Clinical Trial Update: Pilot Study Immunomonitoring Natural Killers Cells in Patients With Myeloid Malignancies Treated With Lenalidomide [NA]

A completed pilot clinical trial evaluated immunomonitoring of natural killer cells in patients with acute myeloid leukemia or myelodysplast…

CLINICAL_TRIALS trial_result · 2015-08-05

Clinical Trial Update: Selumetinib in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia [Phase 2]

Phase 2 clinical trial update evaluating selumetinib in adults with recurrent or refractory acute myeloid leukemia, including AML with t(15;…

CLINICAL_TRIALS trial_result · 2015-07-28

Clinical Trial Update: Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms [Phase 1]

Termination of a Phase 1 trial evaluating oral azacitidine (CC-486) in Japanese subjects with hematological neoplasms.

CLINICAL_TRIALS trial_result · 2015-07-10

Clinical Trial Update: Efficacy and Safety Study of StemEx®, to Treat Subjects With High Risk Hematologic Malignancies, Following Myeloablative Therapy [Phase 2, Phase 3]

This update summarizes a Phase 2/Phase 3 study of StemEx for high-risk hematologic malignancies after myeloablative therapy, focusing on eff…

CLINICAL_TRIALS trial_result · 2015-07-10

Clinical Trial Update: Arsenic Trioxide and Gemtuzumab Ozogamicin in Treating Patients With Advanced Myelodysplastic Syndromes [Phase 2]

Phase 2 clinical trial evaluating arsenic trioxide in combination with gemtuzumab ozogamicin for advanced myelodysplastic syndromes (and ass…

CLINICAL_TRIALS trial_result · 2015-07-01

Clinical Trial Update: MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With Relapsed/Refractory Disease [Phase 2]

Phase 2 trial of MGCD0103 (mocetinostat) in elderly patients with previously untreated acute myeloid leukemia/high-risk myelodysplastic synd…

CLINICAL_TRIALS trial_result · 2015-06-22

Clinical Trial Update: Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy [Phase 1]

This Phase 1 clinical trial update reports the tolerance and biologic activity of oral ciclopirox olamine in patients with relapsed or refra…

CLINICAL_TRIALS trial_result · 2015-06-17

Clinical Trial Update: Study of Farnesyl Protein Transferase Inhibitor (FPTI) in Patients With Leukemia (Study P00701) [Phase 1, Phase 2]

Phase 1/2 trial of a Farnesyl Protein Transferase Inhibitor in leukemia and myelodysplastic syndromes has completed, sponsored by Merck Shar…

CLINICAL_TRIALS trial_result · 2015-06-11

Clinical Trial Update: Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation [EARLY_Phase 1]

An early-phase study update reporting completion of a trial using abdominal CT to predict acute graft-versus-host disease risk after allogen…

CLINICAL_TRIALS trial_result · 2015-06-08

Clinical Trial Update: 5-Fluoro-2'-Deoxycytidine and Tetrahydrouridine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes [Phase 1]

Phase 1 trial assessing 5-Fluoro-2'-Deoxycytidine with tetrahydrouridine in adults with acute myeloid leukemia or myelodysplastic syndromes;…

CLINICAL_TRIALS trial_result · 2015-06-08

Clinical Trial Update: A Standardized Nursing Intervention Protocol for HCT Patients [NA]

This document reports the completion of a clinical trial evaluating a standardized nursing intervention protocol for hematopoietic cell tran…

CLINICAL_TRIALS trial_result · 2015-06-08

Clinical Trial Update: Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant [NA]

Clinical trial update describing a completed study evaluating blood changes in patients at high risk of cytomegalovirus infection after dono…

CLINICAL_TRIALS trial_result · 2015-05-21

Clinical Trial Update: A Study of Oral Clofarabine in Adult Patients With Myelodysplastic Syndromes (MDS) [Phase 1]

Phase 1 trial of oral clofarabine in adults with myelodysplastic Syndromes has been terminated.

CLINICAL_TRIALS trial_result · 2015-05-13

Clinical Trial Update: Phase I Study of Gimatecan in Patients With Myelodysplastic Syndromes [Phase 1]

This document reports results from a Phase I study of the camptothecin analog gimatecan in patients with myelodysplastic syndromes.

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