Myelodysplastic Syndromes

• CLINICAL_TRIALS trial_result · 2017-12-11
  Clinical Trial Update: A Study of RO6870810/TEN-010 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndrome [Phase 1]

  Phase 1 study of RO6870810/TEN-010 in patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes has completed.

• CLINICAL_TRIALS trial_result · 2017-12-08
  Clinical Trial Update: Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies [Phase 2]

  Phase 2 trial evaluating rasburicase and allopurinol in adults with hematologic malignancies; the study was terminated with results posted i…

• CLINICAL_TRIALS trial_result · 2017-12-05
  Clinical Trial Update: AHN-12 Biodistribution in Advanced Leukemia [Phase 1]

  A Phase 1 trial of the investigational agent AHN-12 focusing on biodistribution in advanced leukemia has been terminated.

• CLINICAL_TRIALS trial_result · 2017-12-04
  Clinical Trial Update: Evaluating Cell Damage in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Fanconi Anemia; in Patients Who Were Exposed to Alkylating Agents; and in Healthy Volunteers

  A completed clinical trial evaluating cell damage from alkylating agents in patients with acute myeloid leukemia, myelodysplastic syndromes,…

• CLINICAL_TRIALS trial_result · 2017-12-02
  Clinical Trial Update: Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases [Phase 1]

  Phase 1 trial evaluating the safety of Umbilical Cord Blood T-Regulatory Cell infusion followed by donor cord blood transplant in patients w…

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• CLINICAL_TRIALS trial_result · 2017-12-02
  Clinical Trial Update: T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer [Phase 1]

  Phase 1 clinical trial evaluating infusion of regulatory T cells after umbilical cord blood transplant in patients with advanced hematologic…

• CLINICAL_TRIALS trial_result · 2017-11-30
  Clinical Trial Update: Pilot and Feasibility Study of Reduced-Intensity Hematopoietic Stem Cell Transplant for MonoMAC [Phase 2]

  Phase 2 pilot/feasibility study evaluating reduced-intensity hematopoietic stem cell transplant for MonoMAC syndrome.

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Combination Chemotherapy and Total-Body Irradiation Before Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer, Metastatic Breast Cancer, or Kidney Cancer [Phase 1, Phase 2]

  A Phase 1/2 trial update on using combination chemotherapy and total-body irradiation before donor umbilical cord blood transplant in patien…

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant [Phase 1]

  A Phase 1 trial evaluating donor T cells in high-risk hematologic cancers undergoing donor peripheral blood stem cell transplant was termina…

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer [NA]

  ClinicalTrials.gov entry describes termination of a study evaluating donor umbilical cord blood transplantation for various hematologic canc…

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 in Treating Patients With Advanced Leukemia [Phase 1]

  The update reports termination of a Phase 1 trial evaluating AHN-12, a Yttrium-90 labeled anti-CD45 monoclonal antibody, in advanced leukemi…

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia [NA]

  The document reports the completion of a clinical trial evaluating donor lymphocyte infusion for relapsed leukemia after transplantation acr…

• CLINICAL_TRIALS trial_result · 2017-11-29
  Clinical Trial Update: Chemotherapy and Total-Body Irradiation Followed by Donor Umbilical Cord Blood Transplant, Cyclosporine, and Mycophenolate Mofetil in Treating Patients With Hematologic Cancer [NA]

  This clinical trial update reports completion of a study evaluating chemotherapy and total-body irradiation followed by donor umbilical cord…

• CLINICAL_TRIALS trial_result · 2017-11-20
  Clinical Trial Update: ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies [Phase 1]

  A Phase 1 trial evaluated ABT-348 as a standalone therapy and in combination with azacitidine for advanced hematologic malignancies; the stu…

• CLINICAL_TRIALS trial_result · 2017-11-17
  Clinical Trial Update: Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes [NA]

  This clinical trial evaluated a combination of idarubicin, cytarabine, and pravastatin sodium in adults with acute myeloid leukemia or myelo…

• CLINICAL_TRIALS trial_result · 2017-11-13
  Clinical Trial Update: Eltrombopag Treatment of Thrombocytopenia in Subjects With Advanced Myelodysplastic Syndrome (MDS) or Secondary Acute Myeloid Leukemia After MDS (sAML/MDS) [Phase 1]

  A completed Phase 1 trial evaluating eltrombopag for treating thrombocytopenia in patients with advanced myelodysplastic syndromes or second…

• CLINICAL_TRIALS trial_result · 2017-10-12
  Clinical Trial Update: Low-Dose Fludarabine, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer [Phase 1]

  Phase 1 study evaluating low-dose fludarabine, busulfan, and anti-thymocyte globulin conditioning followed by donor umbilical cord blood tra…

• CLINICAL_TRIALS trial_result · 2017-09-15
  Clinical Trial Update: Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT [Phase 2]

  Phase 2 trial evaluating abatacept-based immunosuppression to prevent acute graft-versus-host disease during unrelated donor hematopoietic c…

• CLINICAL_TRIALS trial_result · 2017-08-22
  Clinical Trial Update: Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic Anemias [Phase 2]

  Phase 2 study of deferasirox for iron overload in beta-thalassemia patients who cannot be treated with deferoxamine, as well as related chro…

• CLINICAL_TRIALS trial_result · 2017-08-22
  Clinical Trial Update: Azacytidine and Bortezomib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes [Phase 1]

  Phase 1 study of azacitidine plus bortezomib in relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes has completed enr…

• CLINICAL_TRIALS trial_result · 2017-08-18
  Clinical Trial Update: Bendamustine and Idarubicin in Treating Older Patients With Previously Untreated AML or MDS [Phase 1, Phase 2]

  This clinical trial update describes the Phase 1/2 results for the combination of bendamustine and idarubicin in older patients with previou…

• CLINICAL_TRIALS trial_result · 2017-08-08
  Clinical Trial Update: A Phase I Clinical Trial of OXi4503 for Relapsed and Refractory AML and MDS [Phase 1]

  Phase I trial of OXi4503 for relapsed and refractory acute myeloid leukemia and myelodysplastic syndromes was terminated.

• CLINICAL_TRIALS trial_result · 2017-07-26
  Clinical Trial Update: A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms

  Completed clinical trial evaluating whether the final Geriatric Assessment in Haematology (GAH) score can predict tolerance to treatment in …

• CLINICAL_TRIALS trial_result · 2017-07-24
  Clinical Trial Update: Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome [Phase 4]

  This Phase 4 trial compares posaconazole to micafungin for preventing invasive fungal infections during neutropenia in patients receiving ch…

• CLINICAL_TRIALS trial_result · 2017-07-19
  Clinical Trial Update: Allogeneic Stem Cell Transplant With Clofarabine, Busulfan and Antithymocyte Globulin (ATG) for Adult Patients With High-risk Acute Myeloid Leukemia/Myelodysplastic Syndromes (AML/MDS) or Acute Lymphoblastic Leukemia (ALL) [Phase 2]

  Phase 2 trial evaluating an allogeneic stem cell transplant regimen combining clofarabine, busulfan, and antithymocyte globulin in adults wi…