Myelodysplastic Syndromes
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: Ferroptosis Study in SF3B1-mutant Myelodysplastic Syndromes (FerMDS) [NA]
A clinical trial is investigating ferroptosis-targeting approaches in SF3B1-mutant myelodysplastic syndromes, and the study is currently rec…
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: Characterization of the Mechanisms of Resistance to Azacitidine
This clinical trial is investigating the mechanisms underlying resistance to azacitidine. It targets patients with myelodysplastic syndromes…
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CLINICAL_TRIALS research · 2025-03-14Clinical Trial Update: Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy [Phase 2]
Phase 2 trial evaluating imetelstat in patients with high-risk myelodysplastic syndromes or acute myeloid leukemia after failure of hypometh…
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CLINICAL_TRIALS research · 2025-03-11Clinical Trial Update: A Trial Testing Early vs Late Onset of EPO Alfa Treatment in Lower Risk MDS [Phase 3]
A Phase 3 trial comparing early versus late onset of epoetin alfa in lower-risk myelodysplastic syndromes. The study is currently active but…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care
A completed clinical trial program in myelodysplastic syndromes focused on genomic characterization to guide clinical decisions and the syst…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: Italian Network MDS Registry
An Italian network registry study for myelodysplastic syndromes and related myeloproliferative neoplasms is currently recruiting participant…
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CLINICAL_TRIALS research · 2025-02-25Clinical Trial Update: PTCy and ATG for MSD and MUD Transplants [Phase 1, Phase 2]
Ongoing Phase 1/2 clinical trial evaluating post-transplant cyclophosphamide and anti-thymocyte globulin for matched sibling and matched unr…
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CLINICAL_TRIALS research · 2025-02-21Clinical Trial Update: Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples
This clinical trial update describes a study on monitoring mutational burden in low-risk myelodysplastic syndrome patients by analyzing sequ…
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Randomized Study of Conditioning of Fludarabine Combined With Single or Dual Alkylating Agents in Myeloid Malignancies [Phase 3]
A Phase 3 randomized trial evaluating conditioning with fludarabine plus single versus dual alkylating agents in myeloid malignancies (acute…
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CLINICAL_TRIALS research · 2025-02-10Clinical Trial Update: Reduced Intensity Conditioning Regimens for Acute Myeloid Leukemia and Myelodysplastic Syndrome [Phase 3]
A Phase 3 clinical trial update evaluating reduced-intensity conditioning regimens for patients with acute myeloid leukemia or myelodysplast…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: Biocollection in MyeloDysplastic Syndrome (P-MDS) [NA]
A clinical trial update indicating that a Biocollection in Myelodysplastic Syndrome study is currently recruiting and targets several MDS su…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: First-in-human Study Aiming to Characterize the Safety, Tolerability, Pharmacokinetic and Preliminary Signs of Activity of ABD-3001 in Refractory or Relapsed AML and High Risk MDS Adult Patients [Phase 1, Phase 2]
First-in-human Phase 1/2 study of ABD-3001 to evaluate safety, tolerability, pharmacokinetics, and preliminary activity in adults with refra…
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CLINICAL_TRIALS research · 2025-01-08Clinical Trial Update: Evaluation of Response to Biosimilar Erythropoietin Alfa Therapy in Anemic Patients With Myelodysplastic Syndrome
A clinical trial is evaluating the response to a biosimilar erythropoietin alfa therapy in anemic patients with myelodysplastic syndromes an…
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CLINICAL_TRIALS research · 2025-01-01Clinical Trial Update: Preventing of GVHD with Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Ruxolitinib At Children and Young Adults with Hemoblastosis [Phase 2, Phase 3]
A multi-agent trial in pediatric and young adult patients explores preventing graft-versus-host disease after transplantation using post-tra…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS [Phase 1]
Nkarta's NKX101 is an intravenous allogeneic CAR-NK cell therapy being studied in adults with relapsed/refractory acute myeloid leukemia and…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG [Phase 3]
Phase 3 randomized trial comparing post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prophylaxis…
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: COaching and Prehabilitation: Faisability Study in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome [NA]
A feasibility study on coaching and prehabilitation for patients with acute myeloid leukemia and myelodysplastic syndromes, sponsored by Ins…
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Prophylactic Intervention for Relapse Prevention Post-Allogeneic Transplantation in Very High-Risk MDS Patients Based on IPSS-M Stratification [Phase 2]
Phase II clinical trial evaluating a prophylactic intervention to prevent relapse after allogeneic transplantation in very high-risk myelody…
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CLINICAL_TRIALS research · 2024-11-08Clinical Trial Update: PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS [Phase 1]
Phase 1 trial update for PRGN-3006 adoptive cellular therapy targeting CD33-positive acute myeloid leukemia, including MRD-positive AML or h…
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CLINICAL_TRIALS research · 2024-10-30Clinical Trial Update: A Multicenter Study on the Treatment of MDS/MPN Overlap Syndrome With AZA or Rux Combined With Selinexor [Phase 2]
Phase 2 multicenter trial evaluating azacitidine or ruxolitinib in combination with selinexor for MDS/MPN overlap syndrome; currently enroll…
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CLINICAL_TRIALS research · 2024-10-22Clinical Trial Update: Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients [NA]
This clinical trial update describes a study on molecular mechanisms of relapse after allogeneic stem cell transplantation in myelodysplasti…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia
This clinical trial update describes a prospective evaluation of diagnosis and treatment among patients with autoimmune cytopenias, includin…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS. [Phase 1]
Phase Ib clinical trial of APG-115 as a single agent or in combination with azacitidine or cytarabine for acute myeloid leukemia or myelodys…
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: VA Conditioning Regimen Allo-HSCT for Elderly Higher-risk MDS [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study of a VA conditioning regimen followed by allogeneic hematopoietic stem cell tra…
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CLINICAL_TRIALS research · 2024-09-27Clinical Trial Update: Transfusion in Lower Risk MDS Patients: Predictors of Adequacy of Transfusion and Quality of Life in Lower Risk MDS
This clinical trial update describes a study in lower-risk myelodysplastic syndromes evaluating predictors of transfusion adequacy and the i…