Myelodysplastic Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies [Phase 3]
A Phase 3 randomized trial evaluating Orca-T in allogeneic stem cell transplantation for hematologic malignancies; results have been posted.
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Long Term Follow-up Study of TScan TCR-T Products
This clinical trial update describes a long-term follow-up study of TScan Therapeutics' TCR-T cell therapies for acute myeloid leukemia, acu…
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CLINICAL_TRIALS trial_result · 2025-09-08Clinical Trial Update: PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK) [Phase 2]
Phase 2 trial of PF-05212384 (PKI-587) for therapy-related AML/MDS and de novo/relapsed or refractory AML was terminated. The update indicat…
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Cord Blood Transplant in Adults With Blood Cancers [Phase 2]
Phase 2 trial evaluating cord blood transplant in adults with blood cancers is currently recruiting. Conditions include acute myeloid leukem…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation [Phase 2]
Phase 2 clinical trial evaluating treosulfan versus melphalan conditioning followed by post-transplant cyclophosphamide in AML and MDS patie…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes [Phase 2]
Phase 2 trial update evaluating the infusion of expanded cord blood cells in addition to a single cord blood transplant for patients with ac…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Feasibility and Safety of Exercise in Patients With Low-risk Myeloid Cancers and Precursor Conditions [NA]
Feasibility and safety of exercise in patients with low-risk myeloid cancers and precursor conditions are being studied in this clinical tri…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation [Phase 2]
This clinical trial update describes a Phase 2 study evaluating TCRγδ T cells and memory T cells with selective use of blinatumomab as part …
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Phase II Decitabine (DAC) Versus Azacitidine (AZA) in Myelodysplastic Syndrome (MDS) [Phase 2]
Phase II trial comparing decitabine versus azacitidine in myelodysplastic syndrome has completed; results were posted on 2025-08-07.
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome [Phase 3]
Phase 3 clinical trial evaluating venetoclax with azacitidine for newly diagnosed higher-risk myelodysplastic syndrome. The study is current…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: STIMULUS MDS-US : Sabatolimab Added to HMA in Higher Risk MDS [Phase 2]
Phase 2 STIMULUS MDS-US trial evaluating Sabatolimab added to hypomethylating agents in higher-risk myelodysplastic syndrome has been termin…
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CLINICAL_TRIALS research · 2025-07-30Clinical Trial Update: Maintenance Therapy With Selinexor and Azacitidine in TP53 Mutant AML/MDS After Transplantation [Phase 1]
This document provides an update on a Phase 1 trial evaluating maintenance therapy with selinexor and azacitidine in patients with TP53-muta…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Reduced Intensity Conditioning for MDS [Phase 2]
Phase 2 trial evaluating reduced intensity conditioning for myelodysplastic syndrome; the study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene [Phase 1]
Phase 1 clinical trial of CASPALLO allodepleted T cells engineered with an inducible caspase-9 suicide gene; the study is currently active b…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial of a radiolabeled anti-CD25 antibody with fludarabine, melphalan, and total marrow and lymphoid irradiation for high-…
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep [Phase 2]
Phase 2 clinical trial evaluating non-myeloablative preparative regimens followed by umbilical cord blood transplantation for various hemato…
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FDA approval · 2025-07-01FDA Approved: AZACITIDINE — Supplemental Application (Panacea Biotec Limited)
FDA approved a supplemental application for azacitidine from Panacea Biotec Limited, allowing the generic azacitidine product to be marketed…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: Open-label Study of FT-2102 With or Without Azacitidine or Cytarabine in Patients With AML or MDS With an IDH1 Mutation [Phase 1, Phase 2]
Open-label Phase 1/2 trial of FT-2102 in IDH1-mutant acute myeloid leukemia and myelodysplastic syndrome, evaluating FT-2102 with or without…
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CLINICAL_TRIALS trial_result · 2025-06-22Clinical Trial Update: Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia [Phase 1]
A Phase 1 clinical trial evaluating total marrow and lymphoid irradiation with chemotherapy before donor transplantation in patients with my…
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: Evaluation of 3 Different Doses of IV Busulfan [Phase 2]
Clinical Trial Update on a Phase 2 study evaluating three different doses of intravenous busulfan in patients with myelodysplastic syndrome …
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome [Phase 3]
Phase 3 trial evaluating response-based chemotherapy in younger patients with Down syndrome who have newly diagnosed acute myeloid leukemia …
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Vaccination Against Human Papillomavirus (HPV) After Allogeneic Stem Cell Transplantation [Phase 2]
This Phase 2 trial investigates HPV vaccination in recipients of allogeneic stem cell transplantation and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation [Phase 2]
Phase 2 trial comparing three GVHD prophylaxis regimens in nonmyeloablative or reduced-intensity conditioning unrelated donor transplantatio…