Myelodysplastic Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics [Phase 1]
Phase 1 study assessing how moderate renal impairment and race/ethnicity influence treosulfan pharmacokinetics in Acute Myeloid Leukemia and…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome [Phase 2]
This document provides a Phase 2 update on a recruiting trial evaluating CPX-351 plus Ivosidenib for IDH1-mutated acute myeloid leukemia and…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers [Phase 2]
Phase 2 trial evaluating Dexrazoxane hydrochloride to prevent heart-related side effects of chemotherapy in people with blood cancers; the s…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
A Phase 1 trial of regorafenib in combination with venetoclax and azacitidine for relapsed or refractory acute myeloid leukemia has been sus…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane [Phase 1]
Phase 1 clinical trial evaluating the highest dose of uproleselan in combination with fludarabine and cytarabine for relapsed or refractory …
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy [Phase 2]
Phase 2 trial evaluating hematopoietic stem cell transplantation using risk-adjusted chemotherapy for patients with Fanconi anemia and sever…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial update on Orca-T after chemotherapy and total marrow and lymphoid irradiation for acute myeloid leukemia, acute lymph…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Guadecitabine and Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapsing After Allogeneic Stem Cell Transplant [Phase 2]
Phase 2 clinical trial evaluating guadecitabine in combination with donor lymphocyte infusion for acute myeloid leukemia, chronic myelomonoc…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia [Phase 2]
Phase 2 clinical trial evaluating a four-drug combination (cladribine, idarubicin, cytarabine, and venetoclax) for acute myeloid leukemia, h…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Personalized NK Cell Therapy in CBT [Phase 2]
A Phase 2 trial from MD Anderson is evaluating personalized NK cell therapy across several hematologic cancers. The study is currently recru…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse [Phase 1, Phase 2]
This clinical trial evaluates decitabine in combination with the FLAG-Ida chemotherapy regimen and total-body irradiation, followed by donor…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1]
This is a Phase 1 trial evaluating SL-401 (tagraxofusp) in combination with azacitidine or azacitidine plus venetoclax for acute myeloid leu…
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1 [Phase 1, Phase 2]
This clinical trial update reports a Phase 1/2 study of the combination omacetaxine mepesuccinate and venetoclax in relapsed or refractory a…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome [Phase 2]
A Phase 2 trial evaluating ruxolitinib with tacrolimus and methotrexate to prevent graft-versus-host disease in pediatric and young adult pa…
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating reduced-intensity conditioning before allogeneic donor stem cell transplantation in patients with high-risk hematol…
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FDA approval · 2025-10-21FDA Approved: DEFERASIROX — Supplemental Application (Actavis Pharma, Inc.)
FDA approved a supplemental application for Deferasirox from Actavis Pharma, Inc. This action updates the regulatory status of the product.
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS) [Phase 1, Phase 2]
Rigel Pharmaceuticals is conducting a Phase 1/2 study of the investigational agent R289 in adults with low-risk myelodysplastic syndrome, an…
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CLINICAL_TRIALS trial_result · 2025-10-21Clinical Trial Update: Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM) [Phase 1]
Phase 1 clinical trial evaluating the administration of donor-derived multi TAA-specific T cells (ADSPAM) for acute myeloid leukemia or myel…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
This trial evaluates a targeted radiopharmaceutical (211At-BC8-B10) followed by an allogeneic donor stem cell transplant for relapsed or ref…
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Q702 for the Treatment of Patients With Hematologic Malignancies [Phase 1]
This entry notes a Phase 1 clinical trial (Q702) for hematologic malignancies led by Mayo Clinic, currently recruiting and including histioc…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating venetoclax-augmented treosulfan-based reduced-intensity conditioning before allogeneic stem cell transplan…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The document announces a new clinical trial called HALO-SCT, assessing high-altitude observation in stem cell transplantation. It is current…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: AB8939 in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial of AB8939 for relapsed or refractory acute myeloid leukemia is currently recruiting. The study also references my…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
MP0533 is being studied in patients with acute myeloid leukemia or myelodysplastic syndrome in a Phase 1/2 trial that is currently recruitin…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: AZD6738 for Patients With Progressive MDS or CMML [Phase 1]
Phase 1 clinical trial update of AZD6738 in patients with progressive myelodysplastic syndrome or chronic myelomonocytic leukemia; the study…