Muscle-invasive Bladder Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Sample Collection for Ongoing Research and Product Evaluation Study
Natera reports an ongoing study update focused on sample collection for ongoing research and product evaluation; the trial is currently recr…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Supporting Sexual Health in Bladder Cancer Patients: A Sequential Mixed-Methods Intervention Study [NA]
A sequential mixed-methods intervention trial to support sexual health in bladder cancer patients, currently recruiting.
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease [Phase 1]
Phase 1 clinical trial update evaluating a Personalized Cancer Vaccine (PCV) strategy in patients with solid tumors, specifically muscle-inv…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm [NA]
This clinical trial update describes a study evaluating multi-parametric MRI for local staging in patients suspected of muscle-invasive blad…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer [Phase 2]
A phase 2 study evaluating nivolumab as adjuvant therapy after chemo-radiation in localized muscle-invasive bladder cancer; the trial is cur…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer [Phase 1]
An open-label, randomized Phase 1b study evaluating a multi-drug, biomarker-directed approach in patients with muscle-invasive bladder cance…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Neoadjuvant Zanidatamab + Tislelizumab + Chemotherapy for Selective Bladder Preservation in HER2-Positive MIBC [Phase 2]
This clinical trial update describes a Phase 2 neoadjuvant study combining zanidatamab, tislelizumab, and chemotherapy to enable selective b…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Erdafitinib Monotherapy or in Combination With Cetrelimab in Muscle-invasive Bladder Cancer Patients With Fibroblast Growth Factor Receptor (FGFR ) Gene Alterations [Phase 2]
A Phase 2 trial is evaluating erdafitinib alone or in combination with cetrelimab for FGFR-altered muscle-invasive bladder cancer, currently…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy [Phase 2]
Phase 2 trial evaluating futibatinib in combination with durvalumab prior to cystectomy for patients with muscle-invasive bladder cancer ine…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Neoadjuvant Immunotherapy Combined With the Anti-GDF-15 Antibody Visugromab to Treat Muscle Invasive Bladder Cancer [Phase 2]
This Phase 2 neoadjuvant trial evaluates Visugromab, an anti-GDF-15 antibody, in combination with immunotherapy for muscle-invasive bladder …
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation [Phase 2]
Phase 2 trial evaluating a non-surgical treatment for muscle-invasive bladder cancer using anti-PD-1 therapy in combination with chemoradiat…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Interest of Late Images for the Assessment of Extensions in 18FGD PET-CT of Muscle-Invasive Bladder Cancers [NA]
A recruiting clinical trial evaluating whether late 18F-FDG PET-CT imaging improves assessment of tumor extensions in muscle-invasive bladde…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Home Intravenous Fluid Infusion After Undergoing Radical Cystectomy [NA]
Clinical trial entry from Johns Hopkins University recruiting to study home intravenous fluid infusion after radical cystectomy for bladder …
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Atezolizumab After Chemo-radiotherapy for MIBC Patients Not Eligible for Radical Cystectomy [Phase 2]
Phase 2 study of atezolizumab after chemo-radiotherapy for muscle-invasive bladder cancer patients who are not eligible for radical cystecto…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Prophylactic Antibiotics in Cystectomy With Diversion [EARLY_Phase 1]
This early-phase 1 trial evaluates prophylactic antibiotics around radical cystectomy with diversion for muscle-invasive bladder cancer and …
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describing safety, tolerability, and imaging with [68Ga]Ga-DPI-4452 and safety, tolerability, and efficacy…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy [NA]
A clinical trial from Assiut University is evaluating whether neoadjuvant chemotherapy affects the accuracy of MRI in staging before cystect…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Early Prediction of Neoadjuvant Chemotherapy Response in Bladder Cancer Using Quantitative Multiparametric MRI
This clinical trial aims to predict early response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using quantitative multipar…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Vedisertib (RC48/ADC) Combined With Toripalimab in Bladder-preserving Treatment [Phase 2]
Phase 2 trial protocol evaluating Vedisertib (RC48/ADC) in combination with Toripalimab for bladder-preserving treatment in muscle-invasive …
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Survival Benefits of Neoadjuvant Systemic Chemotherapy in Muscle Invasive Bladder Cancer
This clinical trial update describes planned research on whether neoadjuvant systemic chemotherapy improves survival in muscle-invasive blad…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Enfortumab Vedotin and Stereotactic Radiation for Localized, Cisplatin Ineligible Muscle Invasive Bladder Cancer [Phase 1, Phase 2]
A Phase 1/2 trial is evaluating enfortumab vedotin in combination with stereotactic radiation for localized, cisplatin-ineligible muscle-inv…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Efficacy and Safety of Two Bladder-preserving Treatment Durations With Disitamab Vedotin Plus Toripalimab Combination in Her2-expressing Muscle-invasive Bladder Cancer: A Phase II, Open-Label, Randomized Clinical Trial [Phase 2]
This Phase II, open-label, randomized trial assesses two bladder-preserving durations of Disitamab Vedotin plus Toripalimab in HER2-expressi…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) [Phase 2]
Phase 2 trial NeoSTOP-IT evaluating gemcitabine/cisplatin plus cemiplimab with or without fianlimab in localized muscle-invasive bladder can…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) [Phase 3]
A Phase 3 trial update evaluating perioperative pembrolizumab plus neoadjuvant chemotherapy versus perioperative placebo with neoadjuvant ch…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303) [Phase 3]
Phase 3 clinical trial MK-3475-905/KEYNOTE-905/EV-303 is testing perioperative pembrolizumab with cystectomy, with or without enfortumab ved…