Monogenic Obesity

• CLINICAL_TRIALS research · 2026-03-12
  Clinical Trial Update: Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin Signaling

  Regeneron announced expanded access to REGN4461 for patients with diseases tied to deficient leptin signaling, including lipodystrophy and m…

• CLINICAL_TRIALS research · 2026-03-10
  Clinical Trial Update: A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults [Phase 3]

  A Phase 3 clinical trial update for Mibavademab to treat obesity caused by LEP gene mutations, involving children, adolescents, and adults, …

• CLINICAL_TRIALS research · 2026-01-08
  Clinical Trial Update: Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice

  This clinical trial update indicates a study evaluating weekly subcutaneous semaglutide for weight loss in adolescents with monogenic obesit…

• CLINICAL_TRIALS research · 2025-08-07
  Clinical Trial Update: Real-life Evaluation of WEGOVY (Semaglutide) Treatment in Adults With Monogenic Obesity (ObGeSema)

  A real-life evaluation study of Wegovy (semaglutide) in adults with monogenic obesity is currently recruiting.

• CLINICAL_TRIALS trial_result · 2024-10-24
  Clinical Trial Update: DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway [Phase 2]

  Phase 2 DAYBREAK trial evaluating setmelanotide in participants with specific gene variants in the MC4R pathway for genetic obesity has comp…

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