Monoclonal Gammopathy of Undetermined Significance
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple Myeloma [Phase 2]
Phase II study of the CD38 antibody daratumumab in high-risk monoclonal gammopathy of undetermined significance (MGUS) and low-risk smolderi…
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CLINICAL_TRIALS trial_result · 2026-02-09Clinical Trial Update: Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma [Phase 2]
A Phase 2 clinical trial evaluating whether metformin can prevent progression from precursor conditions to active multiple myeloma.
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: PROFAST Intervention in Precursor Multiple Myeloma [NA]
A Dana-Farber Cancer Institute trial evaluating the PROFAST intervention in precursor states to multiple myeloma has completed (NCT05565638)…
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss
This clinical trial update reports the development and pilot testing of a new magnetic resonance imaging protocol to quantify multiple myelo…
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) [NA]
A Memorial Sloan Kettering Cancer Center trial is evaluating a plant-based diet in people with Monoclonal Gammopathy of Undetermined Signifi…
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery
This completed clinical trial evaluated the incidence and natural history of monoclonal gammopathy of undetermined significance (MGUS) in pa…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: Screening to Improve Survival in AL Amyloidosis
The clinical trial update reports completion of a screening-based study aimed at improving survival in light-chain (AL) amyloidosis. The stu…
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CLINICAL_TRIALS trial_result · 2021-11-09Clinical Trial Update: Isatuximab in Type I Cryoglobulinemia [Phase 2]
Phase 2 trial update for isatuximab in cryoglobulinemic vasculitis associated with monoclonal gammopathies isatuximab is being studied; curr…
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CLINICAL_TRIALS trial_result · 2019-01-30Clinical Trial Update: Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing IN Gammopathy Patients [Phase 2]
A Phase 2 trial evaluating repeated dosing of a high-dose influenza vaccine in patients with gammopathy (including multiple myeloma and rela…
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CLINICAL_TRIALS trial_result · 2018-09-11Clinical Trial Update: Study of Lenalidomide as a Treatment for Neuropathy Associated With Monoclonal Gammopathy of Undetermined Significance [Phase 2]
Phase 2 trial investigating lenalidomide for neuropathy associated with nonmalignant MGUS; study terminated with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2017-03-16Clinical Trial Update: Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple Myeloma [NA]
ClinicalTrials.gov entry noting the completed study evaluating genomic and psychosocial effects of the 3RP in patients with Monoclonal Gammo…
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CLINICAL_TRIALS trial_result · 2015-06-09Clinical Trial Update: Celecoxib in Preventing Multiple Myeloma in Patients With Monoclonal Gammopathy or Smoldering Myeloma [Phase 2]
A Phase 2 trial update on using celecoxib to prevent progression to multiple myeloma in patients with MGUS or smoldering myeloma; the study …
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CLINICAL_TRIALS trial_result · 2015-04-03Clinical Trial Update: S0309, Repository: Blood/Bone Marrow From Pts. With Myeloma, WM, Amyloidosis, or MGUS.
A SWOG trial (NCT00919139) evaluating a blood/bone marrow repository from patients with multiple myeloma, smoldering myeloma, Waldenström's …
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CLINICAL_TRIALS trial_result · 2015-03-27Clinical Trial Update: Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma [Phase 2]
Phase 2 trial evaluating green tea extract in patients with MGUS and/or smoldering multiple myeloma; the study was terminated with results p…
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CLINICAL_TRIALS trial_result · 2015-01-19Clinical Trial Update: A Study Evaluating the Effects of Siltuximab on the Heart in Patients With Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Indolent Multiple Myeloma [Phase 1]
This Phase 1 trial evaluated the cardiac effects of siltuximab in patients with Monoclonal Gammopathy of Undetermined Significance and Multi…
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CLINICAL_TRIALS trial_result · 2015-01-16Clinical Trial Update: Imaging in MGUS, SMM and MM [Phase 2]
Completed Phase 2 clinical trial evaluating imaging in monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and …
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CLINICAL_TRIALS trial_result · 2014-05-06Clinical Trial Update: Rituximab in Treating Patients With Peripheral Neuropathy Caused by Monoclonal Gammopathy of Undetermined Significance [Phase 2]
Phase 2 trial of rituximab in patients with peripheral neuropathy caused by monoclonal gammopathy of undetermined significance was terminate…
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CLINICAL_TRIALS trial_result · 2014-01-06Clinical Trial Update: Prognostic Study of Markers of Angiogenesis and Coagulability in Patients With Monoclonal Gammopathy [NA]
Clinical trial update reporting completion of a prognostic study of angiogenesis and coagulability markers in patients with monoclonal gammo…
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CLINICAL_TRIALS trial_result · 2013-11-18Clinical Trial Update: Prevention of Disease Progression in Early Stage Indolent B Cell Malignancies. (SMM) [Phase 2]
A Phase 2 trial investigating prevention of disease progression in early-stage indolent B-cell malignancies (MGUS, smoldering multiple myelo…