Mitochondrial Diseases
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: MItochondrial Diabetes LOw Carb- Diet Study [NA]
A clinical trial evaluating a low-carbohydrate diet for mitochondrial diabetes has completed.
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CLINICAL_TRIALS trial_result · 2025-01-10Clinical Trial Update: The KHENERGYC Study [Phase 2]
Phase 2 KHENERGYC study for mitochondrial diseases is currently suspended.
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity [Phase 4]
A Phase 4 clinical trial evaluating the effect of statin therapy on muscle mitochondrial function and aerobic capacity in patients with mito…
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CLINICAL_TRIALS trial_result · 2024-11-29Clinical Trial Update: Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD). [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating resilience-based interventions (PRISM) and narrative-focused care (CFN) in adults with primary mitocho…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases [NA]
A clinical study evaluating hydroxytyrosol for mitochondrial diseases has completed.
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CLINICAL_TRIALS research · 2024-10-28Clinical Trial Update: Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases
The document describes the setup of a reproductive cohort and a predictive genetic counseling model for mitochondrial diseases within a clin…
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CLINICAL_TRIALS trial_result · 2024-09-03Clinical Trial Update: Muscle OXPHOS and Nutrient Homeostasis
This entry reports the completion of a clinical trial studying muscle oxidative phosphorylation and nutrient homeostasis.
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine
A completed Mayo Clinic study reports on genomic profiling and imaging analysis to advance precision mitochondrial medicine.
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: The KHENEREXT Study [Phase 2]
Phase 2 clinical trial update for KHNEREXT study investigating a treatment for mitochondrial diseases, including the m.3243A>G mutation-rela…
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CLINICAL_TRIALS trial_result · 2022-08-31Clinical Trial Update: The KHENERGYZE Study [Phase 2]
Phase 2 trial update for the KHENERGYZE study investigating a treatment for mitochondrial diseases and mitochondrial myopathies (including M…
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CLINICAL_TRIALS trial_result · 2021-08-31Clinical Trial Update: A Study to Evaluate the Safety and Therapeutic Effects of Transplantation of MNV-BM-BLD in Pediatric Patients With Pearson Syndrome [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating safety and therapeutic effects of MNV-BM-BLD transplantation in pediatric patients with Pearson syndro…
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CLINICAL_TRIALS trial_result · 2019-10-29Clinical Trial Update: Mitochondria and Chronic Kidney Disease [Phase 2]
Phase 2 clinical trial on mitochondria-related interventions for symptoms in patients with mitochondrial diseases and those on hemodialysis;…
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CLINICAL_TRIALS trial_result · 2018-06-28Clinical Trial Update: Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
University College London provides an update on a clinical trial investigating imaging of neuromelanin and brain iron in dystonia and parkin…
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease [Phase 2]
This update describes a long-term extension of a Phase 2 trial of cysteamine bitartrate delayed-release capsules (RP103) in children with in…
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CLINICAL_TRIALS trial_result · 2018-02-23Clinical Trial Update: The KHENERGY Study [Phase 2]
Phase 2 trial update for the KHENERGY study in mitochondrial diseases has completed.
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CLINICAL_TRIALS trial_result · 2018-01-03Clinical Trial Update: Heart Rate Variability in Response to Metformin Challenge [Phase 2]
Phase 2 trial update on heart rate variability in response to a metformin challenge; completed with posted results.
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CLINICAL_TRIALS trial_result · 2017-09-21Clinical Trial Update: A Study of Bezafibrate in Mitochondrial Myopathy [Phase 2]
Phase 2 clinical trial of bezafibrate in mitochondrial diseases has completed.
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CLINICAL_TRIALS trial_result · 2017-08-08Clinical Trial Update: Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
Phase B expanded-access trial update on dichloroacetate for congenital lactic acidosis; the trial is no longer available.
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CLINICAL_TRIALS trial_result · 2016-04-06Clinical Trial Update: Nutritional Assessment in Mitochondrial Cytopathy
A completed clinical trial assessing nutritional status in mitochondrial cytopathy, conducted by Insel Gruppe AG and University Hospital Ber…
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CLINICAL_TRIALS trial_result · 2014-05-01Clinical Trial Update: Phase III Trial of Coenzyme Q10 in Mitochondrial Disease [Phase 3]
Phase III trial of Coenzyme Q10 for mitochondrial diseases completed with results posted.
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CLINICAL_TRIALS trial_result · 2012-02-06Clinical Trial Update: Ketones & Mitochondrial Heteroplasmy [EARLY_Phase 1]
An early-phase 1 trial evaluating ketones and mitochondrial heteroplasmy has completed, studying MELAS syndrome and other mitochondrial dise…
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CLINICAL_TRIALS research · 2009-01-29Clinical Trial Update: Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.
This clinical trial update investigates identifying large-scale POLG gene mutations using QMPSF in patients with mitochondrial DNA instabili…