Mgmt-unmethylated Glioblastoma
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells [Phase 1]
Phase 1 clinical trial update for E-SYNC, a CAR T cell therapy using a synNotch EGFRvIII trigger to drive anti-EphA2/IL-13Ralpha2 CAR expres…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma [Phase 1]
Phase 1 trial evaluating mycophenolate mofetil in combination with standard of care for glioblastoma; study status is ACTIVE_NOT_RECRUITING.
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CLINICAL_TRIALS trial_result · 2025-11-13Clinical Trial Update: Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer [Phase 1]
A Phase 1 clinical trial of AMG 232 (KRT-232) in patients with brain cancers including glioblastoma and gliosarcoma was terminated; the stud…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma [Phase 1]
Phase 1 trial evaluating tinostamustine with or without radiation therapy in newly diagnosed MGMT-unmethylated glioblastoma; the study has c…
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CLINICAL_TRIALS trial_result · 2024-06-24Clinical Trial Update: Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma [Phase 1]
A Phase 1 trial evaluating BAL101553 in combination with radiation for newly diagnosed glioblastoma was terminated, with results posted in 2…
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CLINICAL_TRIALS trial_result · 2024-05-01Clinical Trial Update: Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma [Phase 2, Phase 3]
This update reports the results of a randomized Phase 2/3 trial comparing ipilimumab and nivolumab with radiation therapy versus the standar…
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CLINICAL_TRIALS trial_result · 2020-01-13Clinical Trial Update: Repurposing Chlorpromazine in the Treatment of Glioblastoma [Phase 2]
Phase 2 clinical trial exploring repurposing of chlorpromazine for glioblastoma, including MGMT-unmethylated subtype.