Metabolic Dysfunction-associated Steatohepatitis
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [Phase 1]
This Clinical Trial Update reports on a Phase 1 single-ascending and repeated-dose study of LY3849891 in participants with MASLD and MASH, w…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants [Phase 1]
Phase 1 food-effect and relative bioavailability study of ECC4703 in healthy adults, sponsored by Eccogene, relating to Metabolic Dysfunctio…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA
Clinical trial studying the link between metabolic dysfunction-associated steatotic liver disease and mitochondria-associated membranes in p…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH [Phase 2]
A Phase 2 clinical trial evaluating resmetirom in post-liver transplant patients with metabolic dysfunction-associated steatohepatitis (MASH…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Safety, Tolerability, PK, PD, and Immunogenicity of QL2401 in Healthy Chinese Adults [Phase 1]
Phase 1 study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of QL2401 in healthy Chinese adults fo…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)
A clinical-trial update describes a study of PNPLA3 genetic variants in patients with MASLD/MASH in Guadeloupe. The study is currently recru…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Betaine vs. Placebo for Serologically Diagnosed Metabolic Dysfunction-associated Steatohepatitis (MASH) [Phase 2]
Phase 2 clinical trial comparing betaine to placebo for serologically diagnosed metabolic dysfunction-associated steatohepatitis (MASH); the…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Thermoacoustic Method for Estimating Liver Fat Fraction
Clinical trial investigating a thermoacoustic method to estimate liver fat fraction in MASLD/MASH and nonalcoholic fatty liver disease, curr…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus [Phase 2]
Phase 2 clinical trial investigating Chiglitazar in patients with metabolic dysfunction-associated steatohepatitis and type 2 diabetes melli…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH [Phase 2]
A Phase 2 study evaluating Efimosfermin Alfa in participants with biopsy-confirmed compensated cirrhosis due to Metabolic Dysfunction-Associ…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Resmiterom Efficacy & Safety in Patients With MASH [Phase 4]
A Phase 4 clinical trial update indicating that Resmiterom is being studied for efficacy and safety in metabolic dysfunction-associated stea…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Study of UBT251 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH) [Phase 2]
UBT251 is being studied in Phase 2 for metabolic dysfunction-associated steatohepatitis (MASH). The study is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Study of IBI362 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH) [Phase 2]
This is a Phase 2 clinical trial evaluating IBI362 for metabolic dysfunction-associated steatohepatitis (MASH), currently recruiting.
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Digoxin In NASH (CODIN) [Phase 2]
Phase 2 trial (CODIN) evaluating digoxin for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Patients' Perspectives on Metabolic Dysfunction-associated Steatohepatitis: a Qualitative Study
This clinical trial update describes a qualitative study to explore patients' perspectives on metabolic dysfunction-associated steatohepatit…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Endoscopic Ultrasound Shear Wave Elastography Study
Clinical trial update on endoscopic ultrasound shear wave elastography to assess liver stiffness in patients with metabolic dysfunction-asso…
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Behavioral Lifestyle Intervention for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults [NA]
This clinical trial update indicates that a behavioral lifestyle intervention for Metabolic dysfunction-associated steatotic liver disease (…
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: Fibrosis Lessens After Metabolic Surgery [Phase 4]
Phase 4 clinical trial update exploring metabolic surgery to reduce liver fibrosis in metabolic dysfunction-associated steatotic liver disea…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients [NA]
Ongoing clinical trial evaluating a new ultrasound system for non-invasive assessment of liver steatosis in MASLD/MASH patients.
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: Study to Evaluate Safety, Tolerability and Pharmacokinetics of CS060380 in Healthy and Elevated LDL-C Subjects [Phase 1]
Phase 1 study evaluating the safety, tolerability, and pharmacokinetics of CS060380 in healthy and elevated LDL-C subjects; the listed condi…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Fructose is a Metabolic and Inflammatory Pathogenic Factor in Metabolic Dysfunction-associated Steatohepatitis (MASH) [NA]
A clinical trial at Queen Mary University of London is examining fructose as a metabolic and inflammatory factor in metabolic dysfunction-as…
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CLINICAL_TRIALS research · 2025-06-18Clinical Trial Update: Effect of Sinbiotic With Multispecies Probiotics on Liver Parameters Liver Enzymes, Ultrasound, Elastography and Adipokines in Same Cases) in Patients With Metabolic Associated Steatotic Liver Disease. [Phase 2]
Phase 2 clinical trial evaluating the effect of a sinbiotic with multispecies probiotics on liver parameters in patients with MASLD/MASH; tr…
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: To Evaluate the Tolerability, Pharmacokinetics, and Pharmacodynamics of IMM-H014 in Patients With MASH [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for IMM-H014 to assess tolerability, pharmacokinetics, and pharmacodynamics in patients with Metabolic Dys…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM [NA]
A completed clinical trial evaluating the efficacy and safety of CS0159 in combination with semaglutide for patients with Metabolic Dysfunct…
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CLINICAL_TRIALS withdrawal · 2025-05-15Clinical Trial Update: A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis [Phase 3]
Phase 3 study evaluating denifanstat for metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis has been withdrawn.