Metabolic Dysfunction-associated Steatohepatitis
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH [Phase 3]
A Phase 3 trial evaluating efruxifermin in adults with compensated cirrhosis due to NASH/MASH is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH) [Phase 2]
A Phase 2 clinical trial is investigating a thyroid hormone receptor beta (THRβ) agonist alone and in combination with a semicarbazide sensi…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: A Phase 2b, Study Evaluating Miricorilant in Adult Patients With Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH) [Phase 2]
This is a Phase 2b clinical trial update on Miricorilant for nonalcoholic steatohepatitis/metabolic dysfunction-associated steatohepatitis (…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Rezdiffra Pregnancy and Lactation Registry
This clinical trial update notes that Madrigal Pharmaceuticals' Rezdiffra (resmetirom) pregnancy and lactation registry (NCT07541469) is cur…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis [Phase 3]
Akero Therapeutics is conducting a Phase 3 trial of efruxifermin in adults with noncirrhotic NASH/MASH with fibrosis; recruitment is ongoing…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) [Phase 1]
Regeneron is evaluating ALN-CIDEB in a Phase 1 study in adults with metabolic dysfunction-associated steatotic liver disease or metabolic dy…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis [Phase 3]
A Phase 3 clinical trial named LIVERAGE is evaluating Survodutide for metabolic dysfunction-associated steatohepatitis (MASH) with moderate …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH) [Phase 2]
Phase 2 clinical trial to assess tolerability of BI 3802876 in adults with compensated liver cirrhosis due to metabolic dysfunction-associat…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of CS060380 Tablets in Patients With MASH and Obesity [Phase 2]
A Phase 2 clinical trial update indicating that CS060380 tablets for metabolic dysfunction-associated steatohepatitis and obesity are curren…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH [Phase 3]
This clinical trial update describes a Phase 3 study evaluating the efficacy and safety of pegozafermin in patients with compensated cirrhos…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Assessment of Gut Microbiota-Derived Amino Acid Metabolite Production in Patients With MASLD [NA]
A clinical trial from Hospices Civils de Lyon is assessing gut microbiota–derived amino acid metabolite production in patients with MASLD an…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Prospective Cohort Study on Patient With Obesity Undergoing Weight Change
A prospective cohort study investigating weight change in adults with obesity and related metabolic conditions, currently enrolling by invit…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Study of TGM-312-SC01 in Healthy Participants and Adults With MASH [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial of TGM-312-SC01 in healthy participants and adults with metabolic dysfunction-associated steatohepatitis (M…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Assessment of Non-Invasive Testing in Major Liver-Related Outcomes
A clinical trial update indicates a non-invasive testing approach is being studied to assess major liver-related outcomes in MASLD, with enr…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH) [Phase 2]
A Phase 2 clinical trial evaluating HU6 vs placebo in adults with metabolic dysfunction-associated steatohepatitis (MASH); recruitment is on…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic(PK/PD) Profile of ACT500 in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD) [Phase 1]
Phase 1 study evaluating safety, tolerability, and PK/PD of ACT500 in Metabolic dysfunction-associated steatohepatitis; recruitment has not …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Multi-country, Cross-sectional Quantitative Study Exploring Awareness, Understanding, and Perceptions of the Relation Between Cardiorenal Metabolic Conditions and MASLD/MASH Among Healthcare Providers, People With MASLD/MASH, and At-risk Population
A completed multi-country cross-sectional study assessing awareness, understanding, and perceptions of the relationship between cardiorenal …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Exercise for an Aging Liver (EXALIVER) [NA]
EXALIVER is a clinical trial evaluating exercise as an intervention for MASLD and MASH-related liver disease, with the study currently not y…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: High-Risk Transcriptome Molecular Prediction Study of MASH-Associated Colorectal Polyps
Clinical trial update for a high-risk transcriptome molecular prediction study of MASH-associated colorectal polyps, sponsored by Shanghai E…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Evaluation of Miricorilant on Liver Fat in Patients With MASLD [Phase 1]
Phase 1 clinical trial evaluating Miricorilant on liver fat in patients with MASLD, including NASH and related conditions; currently recruit…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition [Phase 2]
Phase 2 clinical trial sponsored by Regeneron evaluating a gene-silencing therapy for Metabolic Dysfunction-associated Steatohepatitis (MASH…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [Phase 1]
This Clinical Trial Update reports on a Phase 1 single-ascending and repeated-dose study of LY3849891 in participants with MASLD and MASH, w…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants [Phase 1]
Phase 1 food-effect and relative bioavailability study of ECC4703 in healthy adults, sponsored by Eccogene, relating to Metabolic Dysfunctio…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA
Clinical trial studying the link between metabolic dysfunction-associated steatotic liver disease and mitochondria-associated membranes in p…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH [Phase 2]
A Phase 2 clinical trial evaluating resmetirom in post-liver transplant patients with metabolic dysfunction-associated steatohepatitis (MASH…