Melanoma
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CLINICAL_TRIALS withdrawal · 2017-07-27Clinical Trial Update: In Vivo Persistence of Adoptively-Transferred TIL Cultured With Akti in People With Metastatic Melanoma [Phase 1]
The Phase 1 trial of adoptively transferred tumor-infiltrating lymphocytes cultured with an Akt inhibitor for metastatic melanoma has been w…
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CLINICAL_TRIALS trial_result · 2017-07-26Clinical Trial Update: Culture and Characterization of Circulating Tumor Cells (CTC) in Melanoma and Other Cancers
This Clinical Trial Update reports the completion of a study on the culture and characterization of circulating tumor cells (CTCs) in melano…
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CLINICAL_TRIALS trial_result · 2017-07-24Clinical Trial Update: BRAF Inhibitor, LGX818, Utilizing a Pulsatile Schedule in Patients With Stage IV or Unresectable Stage III Melanoma Characterized by a BRAFV600 Mutation [Phase 2]
Phase 2 study evaluating pulsatile LGX818 (encorafenib) in BRAFV600-mutant melanoma (stage IV or unresectable stage III) completed with resu…
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CLINICAL_TRIALS trial_result · 2017-07-21Clinical Trial Update: A Phase I Study of TPI 287 - Temozolomide Combination in Melanoma [Phase 1]
A Phase I trial assessing the combination of TPI-287 and temozolomide in melanoma has been terminated.
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CLINICAL_TRIALS withdrawal · 2017-07-21Clinical Trial Update: Adoptive Therapy Using Antigen-Specific CD4 T-Cells [Phase 1]
A Phase 1 trial of adoptive therapy using antigen-specific CD4 T-cells for melanoma and sarcoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Cyclophosphamide and Fludarabine Followed By Interleukin-2 Gene-Modified Tumor Infiltrating Lymphocytes in Treating Patients With Metastatic Melanoma [Phase 1, Phase 2]
Phase 1/2 trial evaluating cyclophosphamide and fludarabine followed by interleukin-2 gene-modified tumor-infiltrating lymphocytes in metast…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat [Phase 1, Phase 2]
A terminated Phase 1/2 clinical trial from the University of Iowa evaluated a combination of decitabine, temozolomide, and panobinostat for …
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Temozolomide Alone or With Pegylated Interferon-Alpha 2b (PGI) in Melanoma Patients [Phase 2]
Phase 2 trial evaluating temozolomide alone or with pegylated interferon-alpha 2b (PGI) in melanoma has completed with results posted.
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CLINICAL_TRIALS research · 2017-07-02Clinical Trial Update: Genetic Analysis of Familial Melanoma
A National Human Genome Research Institute-sponsored clinical trial examining genetic factors in familial melanoma has completed. The docume…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Microarray Analysis for Human Genetic Disease
This clinical trial update notes the completed status of a National Human Genome Research Institute–sponsored microarray analysis study in h…
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CLINICAL_TRIALS trial_result · 2017-06-27Clinical Trial Update: An Observational Study of BRAF Inhibitors Effectiveness in Patients With Newly Diagnosed Metastatic Melanoma
A completed observational study evaluated how well BRAF inhibitors work in patients with newly diagnosed metastatic melanoma.
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CLINICAL_TRIALS trial_result · 2017-06-23Clinical Trial Update: Study of NY-ESO-1 ISCOMATRIX® in Patients With Measurable Stage III or IV Melanoma [Phase 2]
Phase 2 study of NY-ESO-1 ISCOMATRIX in patients with measurable Stage III/IV melanoma has completed with results posted.
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CLINICAL_TRIALS trial_result · 2017-06-23Clinical Trial Update: Dabrafenib Alone and in Combination With Trametinib Before Surgery in Treating Patients With Locally or Regionally Advanced Melanoma That Can Be Removed By Surgery [Phase 2]
Phase 2 study evaluating dabrafenib alone and with trametinib as neoadjuvant therapy before surgery in locally or regionally advanced melano…
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CLINICAL_TRIALS trial_result · 2017-06-23Clinical Trial Update: Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma [Phase 2]
Phase 2 trial of vemurafenib/cobimetinib with or without bevacizumab in stage IV BRAFV600 mutant melanoma was terminated; results were poste…
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FDA approval · 2017-06-22FDA Approved: MEKINIST — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for MEKINIST (trametinib) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2017-06-22Clinical Trial Update: Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery [Phase 1]
Phase 1 trial of a vaccine therapy for recurrent stage III/IV melanoma not removable by surgery has completed.
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CLINICAL_TRIALS research · 2017-06-12Clinical Trial Update: Vaccination of Patients With Stage IV Melanoma With Dendritic Cells [Phase 1, Phase 2]
Clinical trial update on vaccination of stage IV melanoma patients with dendritic cell vaccines (Phase 1/Phase 2) with completed status.
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CLINICAL_TRIALS trial_result · 2017-06-07Clinical Trial Update: Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVR [NA]
A completed clinical trial investigates improving adherence to oral cancer agents and self-care of symptoms using an IVR system, sponsored b…
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CLINICAL_TRIALS trial_result · 2017-06-06Clinical Trial Update: Infrared Lymphangiography as a Method of Sentinel Node Identification [NA]
This clinical trial evaluated infrared lymphangiography as a method to identify sentinel lymph nodes in melanoma patients; the study is comp…
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CLINICAL_TRIALS trial_result · 2017-06-06Clinical Trial Update: Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery [NA]
Clinical trial evaluating intravital microscopy to identify tumor vessels in melanoma patients undergoing surgical removal; study status com…
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CLINICAL_TRIALS trial_result · 2017-06-01Clinical Trial Update: Tumor Infiltrating Lymphocytes Adjuvant Therapy of Melanoma [Phase 3]
A Phase 3 trial evaluating tumor-infiltrating lymphocytes as adjuvant therapy for melanoma has completed.
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CLINICAL_TRIALS safety_alert · 2017-05-31Clinical Trial Update: Interleukin-2-Induced Cognitive/Affective/Sleep Symptoms
A clinical trial update notes cognitive, affective, and sleep symptoms linked to high-dose interleukin-2. The conditions involved are metast…
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CLINICAL_TRIALS trial_result · 2017-05-31Clinical Trial Update: IPI Biochemotherapy for Chemonaive Patients With Metastatic Melanoma [Phase 1]
Phase 1 trial of ipilimumab-based biochemotherapy in chemonaive patients with metastatic melanoma was terminated. The document notes the sta…
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Melanomas Excised in Primary Care vs Secondary Care Excision
A completed clinical trial comparing melanoma excisions performed in primary care settings versus secondary care (specialist) settings.
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CLINICAL_TRIALS trial_result · 2017-05-25Clinical Trial Update: Monoclonal Antibody Therapy in Treating Patients With Stage IV Melanoma [Phase 1]
Phase 1 trial of a monoclonal antibody therapy for stage IV melanoma has completed.