Melanoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-11-21Clinical Trial Update: A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients [Phase 1]
Phase I study evaluating ABT-888 (veliparib) with temozolomide in patients with various cancers, including metastatic melanoma. The trial st…
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CLINICAL_TRIALS trial_result · 2017-11-20Clinical Trial Update: Aldesleukin With or Without Vaccine Therapy in Treating Patients With Locally Advanced or Metastatic Melanoma [Phase 3]
Phase 3 trial evaluating Aldesleukin with or without vaccine therapy in locally advanced or metastatic melanoma has completed, and the resul…
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CLINICAL_TRIALS trial_result · 2017-11-14Clinical Trial Update: Study of Dabrafenib +/- Trametinib in Combination With Ipilimumab for V600E/K Mutation Positive Metastatic or Unresectable Melanoma [Phase 1]
A Phase 1 trial evaluating dabrafenib with or without trametinib in combination with ipilimumab for patients with V600E/K mutation‑positive …
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FDA approval · 2017-11-06FDA Approved: ZELBORAF — Supplemental Application (Genentech, Inc.)
FDA approved a supplemental application for Zelboraf (vemurafenib) submitted by Genentech, Inc., approving a change associated with the supp…
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CLINICAL_TRIALS research · 2017-10-30Clinical Trial Update: Immunotherapy Study of Evofosfamide in Combination With Ipilimumab [Phase 1]
A Phase 1 clinical trial update on evofosfamide in combination with ipilimumab for cancer treatment. The study targets pancreatic cancer, me…
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CLINICAL_TRIALS trial_result · 2017-10-18Clinical Trial Update: Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Combination With Cisplatin, Vinblastine, and Temozolomide in Treating Patients With Recurrent or Metastatic Melanoma [Phase 1, Phase 2]
Phase 1/2 trial evaluating RO4929097 (gamma-secretase/Notch pathway inhibitor) with cisplatin, vinblastine, and temozolomide in recurrent or…
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CLINICAL_TRIALS trial_result · 2017-10-09Clinical Trial Update: Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma [Phase 1, Phase 2]
This trial update reports results from a Phase 1/2 study evaluating ipilimumab with or without talimogene laherparepvec (T-VEC) in patients …
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CLINICAL_TRIALS research · 2017-10-09Clinical Trial Update: Promoting Early Detection of Melanoma During the Mammography Experience [NA]
Northwestern University is conducting a clinical trial to promote early detection of melanoma during the mammography experience. The study s…
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CLINICAL_TRIALS trial_result · 2017-09-26Clinical Trial Update: Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067) [Phase 3]
Phase 3 CheckMate 067 in previously untreated advanced melanoma compared nivolumab alone or with ipilimumab against ipilimumab alone. Result…
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CLINICAL_TRIALS trial_result · 2017-09-19Clinical Trial Update: Immunotherapy Using 41BB Selected Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma [Phase 2]
Phase 2 trial update for immunotherapy using 41BB-selected tumor infiltrating lymphocytes in metastatic melanoma; study terminated with post…
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CLINICAL_TRIALS trial_result · 2017-09-15Clinical Trial Update: Study Comparing Pembrolizumab With Dual MAPK Pathway Inhibition Plus Pembrolizumab in Melanoma Patients [Phase 2]
Phase 2 trial update comparing pembrolizumab with dual MAPK pathway inhibition plus pembrolizumab in metastatic melanoma is reported as ongo…
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FDA approval · 2017-09-13FDA Approved: ZELBORAF — Supplemental Application (Genentech, Inc.)
The FDA approved a supplemental application for Zelboraf (vemurafenib) submitted by Genentech, Inc. The action updates the product labeling …
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CLINICAL_TRIALS trial_result · 2017-08-31Clinical Trial Update: Multiple Antigen-Engineered DC Vaccine for Melanoma [Phase 1]
A Phase 1 trial evaluating a multiple antigen-engineered dendritic cell vaccine for melanoma has completed.
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CLINICAL_TRIALS trial_result · 2017-08-29Clinical Trial Update: Phase I Endovenous Administration of Oncolytic Adenovirus ICOVIR-5 in Patients With Advanced or Metastatic Melanoma [Phase 1]
Phase I study evaluating endovenous administration of the oncolytic adenovirus ICOVIR-5 in patients with locally advanced or metastatic mela…
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CLINICAL_TRIALS withdrawal · 2017-08-24Clinical Trial Update: Low-dose Cyclophosphamide and Outpatient IV Interleukin-2 in Metastatic Melanoma [Phase 2]
Phase 2 trial of low-dose cyclophosphamide with outpatient IV interleukin-2 in metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-08-21Clinical Trial Update: Study of a DNA Immunotherapy to Treat Melanoma [Phase 1, Phase 2]
The Phase 1/Phase 2 clinical trial of a DNA immunotherapy for malignant melanoma sponsored by Scancell Ltd has been terminated.
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CLINICAL_TRIALS trial_result · 2017-08-17Clinical Trial Update: A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma [Phase 1]
A Phase I trial of a humanized anti-GD2 antibody in children and adolescents with neuroblastoma, osteosarcoma, Ewing sarcoma, and melanoma h…
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CLINICAL_TRIALS trial_result · 2017-08-17Clinical Trial Update: A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer [Phase 1]
This Phase 1 trial update reports results for a NY-ESO-1 vaccine with the GLA-SE adjuvant in patients with unresectable or metastatic cancer…
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CLINICAL_TRIALS trial_result · 2017-08-16Clinical Trial Update: A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanoma [Phase 2]
Phase 2 biomarker-enriched study of TH-302 (evofosfamide) in subjects with advanced/metastatic melanoma was terminated; results were posted …
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CLINICAL_TRIALS trial_result · 2017-08-16Clinical Trial Update: Dendritic Cells (DC) Vaccine for Metastatic Melanoma [Phase 2]
Phase 2 clinical trial update on a dendritic cell vaccine for metastatic melanoma; the study was terminated and results were posted in 2017.
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CLINICAL_TRIALS withdrawal · 2017-08-15Clinical Trial Update: Access Study of Trametinib for Subjects With Advanced Unresectable (Stage IIIc) or Distant Metastatic (Stage IV) BRAF V600E/K Mutation Positive Cutaneous Melanoma
This trial update notes that the Access Study of trametinib in advanced unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma is…
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CLINICAL_TRIALS trial_result · 2017-08-04Clinical Trial Update: Pilot Study of IFN α2b for Melanoma Patients [EARLY_Phase 1]
A Phase 1 pilot trial of interferon alfa-2b in melanoma has been terminated.
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: Phase 2 Study of Ipilimumab in Children and Adolescents (12 to < 18 Years) With Previously Treated or Untreated, Unresectable Stage III or Stage lV Malignant Melanoma [Phase 2]
Phase 2 study of ipilimumab in children and adolescents with unresectable or metastatic malignant melanoma was terminated, with results post…
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CLINICAL_TRIALS withdrawal · 2017-08-01Clinical Trial Update: A Study of Anti-PD-1 (Pembrolizumab) Therapy in Metastatic Melanoma (ADAPTeM) [Phase 2]
The ADAPTeM Phase 2 trial of pembrolizumab for metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-07-27Clinical Trial Update: Anti-Tumor Activity Of SB-485232 In Patients With Previously Untreated Metastatic Melanoma [Phase 2]
Phase 2 trial update showing anti-tumor activity of SB-485232 in patients with previously untreated metastatic melanoma.