Melanoma
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CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: One-year Recurrence-free Survival of Melanoma Patients Eligible for a Sentinel Lymph Node Biopsy
A clinical trial update reporting the one-year recurrence-free survival among melanoma patients eligible for sentinel lymph node biopsy.
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CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: A Study to Compare How Effective is Encorafenib Plus Binimetinib in Real-world and Clinical Trial Settings
A Pfizer-sponsored study compares the real-world effectiveness of encorafenib plus binimetinib against outcomes seen in clinical trials for …
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: A Prospective Study of Plasma Genotyping as a Noninvasive Biomarker for Genotype-directed Cancer Care
This entry describes a prospective clinical trial evaluating plasma genotyping as a noninvasive biomarker to guide genotype-directed cancer …
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC) [Phase 2]
Phase 2 clinical trial evaluating bosentan in patients with metastatic melanoma treated with dacarbazine (DTIC) has completed; Actelion spon…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Melanoma Patients Immunized with Natural DenDritic Cells [Phase 3]
Phase 3 trial evaluating immunization of melanoma patients with natural dendritic cells has completed.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers [Phase 1]
Phase 1 study of cosibelimab (CK-301) as a single-agent therapy in adults with advanced cancers; the trial status is active but not recruiti…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Genomic Investigation of Unusual Responders
This clinical trial update describes a University Health Network study investigating genomic factors in unusual responders across multiple c…
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors [Phase 2]
Phase 2 study evaluating talimogene laherparepvec (T-VEC) with or without radiotherapy in melanoma and Merkel cell carcinoma (and other soli…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL) [Phase 2]
Phase 2 clinical trial evaluating a pragmatic adoptive cell therapy approach using an IL2 analog (ANV419) versus high-dose IL-2 after tumor-…
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CLINICAL_TRIALS trial_result · 2025-01-24Clinical Trial Update: An Observational Study of Adjuvant (Post-surgery) Therapy With Nivolumab for Resected (Completely Removed) Melanoma in Australia
An observational study in Australia is evaluating adjuvant nivolumab after surgical resection of melanoma; the study has completed.
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CLINICAL_TRIALS trial_result · 2025-01-23Clinical Trial Update: Clinical Trial of Phenformin in Combination With BRAF Inhibitor + MEK Inhibitor for Patients With BRAF-mutated Melanoma [Phase 1]
This update reports the completion of a Phase 1 trial evaluating phenformin in combination with a BRAF inhibitor and a MEK inhibitor for pat…
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CLINICAL_TRIALS research · 2025-01-23Clinical Trial Update: Investigation of the Performance of the Medical Device Dermalyser in Determining Melanoma Thickness Based on Dermoscopy Images
This clinical trial aims to evaluate the performance of the Dermalyser device in determining melanoma thickness from dermoscopy images; the …
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: A Study of SEA-CD40 Given With Other Drugs in Cancers [Phase 2]
Phase 2 study of SEA-CD40 in combination with other therapies for melanoma and non-small cell lung cancer has completed and results were pos…
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CLINICAL_TRIALS other · 2025-01-22Clinical Trial Update: Statins to Prevent Immune Checkpoint Inhibitor-induced PRogression of AtherosLerosis [Phase 4]
Phase 4 clinical trial update from Erasmus Medical Center examining whether statins can prevent progression of atherosclerosis in patients r…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: T-cell Therapy with CRISPR PD1-edited Tumor Infiltrating Lymphocytes for Patients with Metastatic Melanoma [Phase 1]
A Phase 1 clinical trial evaluating CRISPR PD-1-edited tumor-infiltrating lymphocytes for metastatic melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: Clinical and Ultrasound Incidence of Rheumatologic Immune Related Adverse Events in Stage IIB-IV Melanoma Patients
A clinical trial update assessing the clinical and ultrasound incidence of rheumatologic immune-related adverse events in melanoma patients …
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma [Phase 2]
Phase 2 trial evaluating pembrolizumab with standard chemotherapy, tumor-infiltrating lymphocytes, and high- or low-dose aldesleukin in pati…
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2) [Phase 1, Phase 2]
This document is a completed Phase 1/Phase 2 clinical trial update for CAB-ROR2-ADC evaluating safety and efficacy in non-small cell lung ca…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: UV1 Vaccination Plus Nivolumab and Ipilimumab in Treatment of Melanoma [Phase 2]
A Phase 2 study evaluating UV1 vaccination in combination with nivolumab and ipilimumab for malignant melanoma has completed and posted resu…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes [Phase 2]
Results from a Phase 2 trial evaluating nivolumab in combination with talazoparib in patients with metastatic or unresectable melanoma carry…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: BGB324 in Combination With Pembrolizumab or Dabrafenib/Trametinib in Metastatic Melanoma [Phase 1, Phase 2]
Clinical trial update reporting phase 1/2 results for bemcentinib (BGB324) in combination with pembrolizumab or with dabrafenib/trametinib i…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo
This completed clinical trial update examines the incidence of melanoma and non-melanoma skin cancers in people with vitiligo, with results …
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Radiotherapy As an Immunological Booster in Patients with Metastatic Melanoma or Renal Cell Carcinoma Treated with High-dose Interleukin-2 [Phase 2]
Phase 2 trial evaluating radiotherapy as an immunological booster in patients with metastatic melanoma or metastatic renal cell carcinoma tr…
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CLINICAL_TRIALS research · 2025-01-09Clinical Trial Update: EMDR for Fear of Cancer Recurrence in Patients with Familial Melanoma: a Waiting List Control Trial [NA]
A clinical trial from Leiden University Medical Center is evaluating EMDR therapy as a waiting-list controlled intervention to reduce fear o…
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CLINICAL_TRIALS trial_result · 2025-01-06Clinical Trial Update: A Study to Assess YH003 in Combination with Toripalimab(anti-PD-1 MAb) Injection in Patients with Cancers [Phase 2]
Phase 2 study evaluating YH003 in combination with toripalimab in patients with melanoma and pancreatic ductal adenocarcinoma has completed.