Malignant Peripheral Nerve Sheath Tumor
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 [Phase 1]
A Phase 1 trial investigating the transformation of plexiform neurofibromas into malignant peripheral nerve sheath tumors in Neurofibromatos…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors [Phase 1]
Phase 1 clinical trial update for Metarrestin (ML-246) in subjects with metastatic solid tumors; the study is currently recruiting across mu…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor [Phase 1, Phase 2]
This clinical trial update reports on the safety and efficacy evaluation of the investigational agent BMS-986504 in unresectable malignant p…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins
A Department of Defense-funded clinical trial at MD Anderson Cancer Center aims to identify metabolic markers and develop a statistical meth…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Natural History Study of Patients With Neurofibromatosis Type I
The National Cancer Institute is conducting an observational natural history study of patients with Neurofibromatosis Type 1. The study is c…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma [Phase 1]
Phase 1 trial evaluating nivolumab plus BO-112 as a neoadjuvant treatment before surgery for resectable soft tissue sarcoma, including multi…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast
Expanded access (compassionate use) for the DNG64-CAR-V cell therapy in patients with advanced pancreatic cancer, various sarcoma subtypes, …
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas [Phase 2]
A Phase 2 clinical trial evaluating a combination of selumetinib, a bromodomain inhibitor, and durvalumab for sarcomas, with recruitment not…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: SPEARHEAD-3 Pediatric Study [Phase 1, Phase 2]
SPEARHEAD-3 is a pediatric study enrolling in Phase 1 and Phase 2 across multiple cancers, including synovial sarcoma, malignant peripheral …
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST) [Phase 2]
This document announces a Phase 2 clinical trial evaluating ASTX727 in malignant peripheral nerve sheath tumors (MPNST), currently recruitin…
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CLINICAL_TRIALS trial_result · 2026-02-04Clinical Trial Update: Tazemetostat in Malignant Peripheral Nerve Sheath Tumors [Phase 2]
Phase 2 trial results for tazemetostat in malignant peripheral nerve sheath tumors have been posted, and the study is currently not recruiti…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST] [EARLY_Phase 1]
Early-phase window-of-opportunity trial evaluating the combination of mirdametinib and vorinostat for NF1-associated, H3K27 trimethylation-d…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1
This Johns Hopkins University study is developing multi-parameter biomarkers to predict malignant transformation in Neurofibromatosis type 1…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Neurofibromatosis Type 1 Tumor Early Detection Study
This clinical trial update announces a study for early detection of tumors in Neurofibromatosis Type 1, and the study is currently recruitin…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) [Phase 2]
Phase 2 trial evaluating an immuno-oncology combination as first-line treatment for soft tissue sarcomas; currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion [Phase 1]
Bristol-Myers Squibb is conducting a Phase 1 trial of MRTX1719 in MTAP-deleted solid tumors, including mesothelioma, non-small cell lung can…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors [Phase 2]
A Phase 2 clinical trial evaluating selinexor in Wilms tumor, rhabdoid tumors, and other solid tumors is currently recruiting at Memorial Sl…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor [Phase 1]
Phase 1 study evaluating neoadjuvant nivolumab plus ipilimumab for newly diagnosed malignant peripheral nerve sheath tumor. The trial status…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 study of APG-115 alone or with pembrolizumab in metastatic melanoma and other advanced solid tumors; the trial is currently active…
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma [Phase 2]
A Phase 2 trial evaluating MASCT-I in combination with doxorubicin and ifosfamide as first-line therapy for advanced soft tissue sarcoma is …
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST [Phase 1, Phase 2]
An early-phase clinical trial is evaluating the combination of a MEK inhibitor and an MDM2 inhibitor in patients with Neurofibromatosis type…
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults [Phase 2]
A Phase 2 trial evaluating donor stem cell transplant after chemotherapy for recurrent or refractory high-risk solid tumors in pediatric and…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients [Phase 1]
Phase 1 study evaluating different dosing schedules of Selinexor in soft tissue sarcoma and related tumors has completed.
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors [Phase 1, Phase 2]
The trial investigated PLX3397 plus sirolimus in unresectable sarcoma and malignant peripheral nerve sheath tumor; the study was terminated,…
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CLINICAL_TRIALS trial_result · 2024-09-27Clinical Trial Update: Vaccine Therapy in Treating Patients with Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery [Phase 1]
This Phase 1 clinical trial evaluated a vaccine therapy for malignant peripheral nerve sheath tumors that are metastatic, recurrent, or unre…