Malignant Melanoma
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CLINICAL_TRIALS trial_result · 2014-01-06Clinical Trial Update: Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma [Phase 3]
Phase 3 trial evaluating dacarbazine with or without oblimersen in advanced malignant melanoma has completed.
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CLINICAL_TRIALS trial_result · 2014-01-06Clinical Trial Update: Oblimersen and Dacarbazine in Treating Patients With Advanced Malignant Melanoma That Has Responded to Treatment on Clinical Trial GENTA-GM301 [NA]
A clinical trial update on oblimersen plus dacarbazine for advanced malignant melanoma that previously responded to treatment in the GENTA-G…
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CLINICAL_TRIALS trial_result · 2013-12-19Clinical Trial Update: Vaccine Therapy in Treating Patients With Malignant Melanoma [Phase 2]
A Phase 2 clinical trial evaluating a vaccine therapy for malignant melanoma is underway. The current status is unknown.
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CLINICAL_TRIALS trial_result · 2013-09-12Clinical Trial Update: Multicentre, Dose Finding, Ph II,CP-4055 in Comb. With Sorafenib - Patients With Metastatic Malignant Melanoma [Phase 2]
A multicenter Phase 2 dose-finding trial of CP-4055 in combination with sorafenib for metastatic malignant melanoma has completed.
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CLINICAL_TRIALS trial_result · 2013-07-08Clinical Trial Update: Comparison Study of Dendritic Cell Vaccine With and Without Cyclophosphamide to Treat Stage IV Melanoma Patients [Phase 2]
Phase 2 study evaluating a dendritic cell vaccine with or without cyclophosphamide for stage IV malignant melanoma was terminated.
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CLINICAL_TRIALS trial_result · 2013-06-26Clinical Trial Update: 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic Malignant Melanoma [Phase 2]
Phase 2 trial of tanespimycin (17-AAG) for metastatic malignant melanoma has completed. Sponsor: Cancer Research UK.
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CLINICAL_TRIALS trial_result · 2013-06-20Clinical Trial Update: Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma [Phase 2]
Phase 2 trial evaluating a vaccine therapy with or without interleukin-2 for metastatic melanoma has completed.
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FDA approval · 2013-05-29FDA Approved: TAFINLAR — Original Application (Novartis Pharmaceuticals Corporation)
FDA approved TAFINLAR (dabrafenib) as an original application for the treatment of unresectable or metastatic malignant melanoma with BRAF V…
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CLINICAL_TRIALS trial_result · 2013-01-31Clinical Trial Update: S9903: Whole Brain Radiotherapy Followed By Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases [Phase 2]
Phase 2 trial S9903 evaluating whole brain radiotherapy followed by stereotactic radiosurgery for limited melanoma brain metastases; the tri…
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CLINICAL_TRIALS trial_result · 2013-01-25Clinical Trial Update: Vaccine Therapy and Sargramostim in Treating Patients With Stage IV Malignant Melanoma [NA]
A completed clinical trial evaluating a vaccine therapy plus sargramostim in patients with stage IV malignant melanoma.
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CLINICAL_TRIALS trial_result · 2013-01-17Clinical Trial Update: Bevacizumab and Sorafenib in Treating Patients With Unresectable Stage III or Stage IV Malignant Melanoma [Phase 2]
Phase 2 trial evaluating bevacizumab and sorafenib in unresectable stage III or stage IV malignant melanoma has completed and results were p…
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CLINICAL_TRIALS trial_result · 2013-01-16Clinical Trial Update: PS-341 in Treating Patients With Metastatic Malignant Melanoma [Phase 2]
This entry reports the completion of a Phase 2 trial evaluating PS-341 (bortezomib) in patients with recurrent or stage IV malignant melanom…
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CLINICAL_TRIALS trial_result · 2013-01-16Clinical Trial Update: Vaccination With Tumor mRNA in Metastatic Melanoma - Fixed Combination Versus Individual Selection of Targeted Antigens [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluating a tumor mRNA vaccine in metastatic melanoma, comparing a fixed combination of targeted antig…
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CLINICAL_TRIALS trial_result · 2013-01-16Clinical Trial Update: Local Treatment of Metastatic Melanoma With Autologous Lymphocytes and the Bispecific Antibody rM28 [Phase 1, Phase 2]
This clinical trial update reports completion of a Phase 1/Phase 2 study evaluating local treatment of metastatic melanoma using autologous …
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CLINICAL_TRIALS trial_result · 2012-12-04Clinical Trial Update: Efficacy Study Of P276-00 In Subjects Of Malignant Melanoma Positive For Cyclin D1 Expression [Phase 2]
The document provides an update on the Phase 2 efficacy study of the investigational drug P276-00 in Cyclin D1-positive malignant melanoma; …
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CLINICAL_TRIALS trial_result · 2012-10-16Clinical Trial Update: Immunohistochemical Expression Patterns of microRNA Processing Enzyme Dicer in Cutaneous Malignant Melanoma, Benign and Dysplastic Melanocytic Naevi
Completed study evaluating immunohistochemical expression of Dicer, a microRNA processing enzyme, in cutaneous malignant melanoma and benign…
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CLINICAL_TRIALS trial_result · 2012-09-07Clinical Trial Update: Study of Heat Shock Protein-Peptide Complex (HSPPC-96) Versus IL-2/DTIC for Stage IV Melanoma [Phase 3]
A Phase 3 trial comparing Heat Shock Protein-Peptide Complex-96 (HSPPC-96) to IL-2 plus dacarbazine in Stage IV malignant melanoma has compl…
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CLINICAL_TRIALS trial_result · 2012-07-10Clinical Trial Update: Sorafenib With Either Temsirolimus or Tipifarnib in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed By Surgery [Phase 2]
Phase 2 clinical trial evaluating sorafenib in combination with temsirolimus or tipifarnib in patients with stage IV malignant melanoma that…
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CLINICAL_TRIALS trial_result · 2012-06-06Clinical Trial Update: CP-675,206 In Patients With Advanced Melanoma [Phase 2]
A Phase 2 trial evaluating CP-675,206 in patients with advanced malignant melanoma has completed. The trial was sponsored by AstraZeneca.
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CLINICAL_TRIALS trial_result · 2012-05-03Clinical Trial Update: A Phase II Trial OF Carboplatin, ABI-007 (Abraxane) And Sorafenib (BAY 43-9006) in Metastatic Melanoma [Phase 2]
A Phase II trial evaluating carboplatin, Abraxane (paclitaxel protein-bound particles), and sorafenib in metastatic melanoma has completed.
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CLINICAL_TRIALS trial_result · 2012-05-03Clinical Trial Update: Phase II Trial of (IL-2) With Priming and (GM-CSF) in Patients With Advanced Melanoma [Phase 2]
Phase II trial evaluating interleukin-2 with priming and GM-CSF in advanced malignant melanoma has completed.
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CLINICAL_TRIALS trial_result · 2012-04-04Clinical Trial Update: Radiation Therapy and Concurrent Cisplatin Chemotherapy for Locally Advanced or Metastatic Malignant Melanoma [Phase 2]
A Phase 2 study evaluating radiation therapy with concurrent cisplatin chemotherapy for locally advanced or metastatic malignant melanoma wa…
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CLINICAL_TRIALS trial_result · 2012-03-14Clinical Trial Update: Study of the Tumor Saturation and Biological Activity of MEDI-522 (Abergrin) in Patients With Advanced Malignant Melanoma [Phase 1]
Phase 1 clinical trial update for MEDI-522 (Abergrin) in patients with advanced malignant melanoma; study completed.
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CLINICAL_TRIALS trial_result · 2012-01-05Clinical Trial Update: Pharmacokinetic Study of Liposomal Vincristine in Patients With Malignant Melanoma & Hepatic Dysfunction [Phase 1]
Phase 1 pharmacokinetic study of liposomal vincristine in patients with malignant melanoma and hepatic dysfunction has completed; results po…
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EMA approval · 2011-12-16European Medicines Agency recommends approval of first-in-class treatment for metastatic or unresectable melanoma
EMA recommends approval of a first-in-class treatment for metastatic or unresectable melanoma, indicating a new mechanism is being brought t…