Malignant Glioma
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CLINICAL_TRIALS trial_result · 2017-04-06Clinical Trial Update: The Roles of Tissue Factor in Malignant Gliomas
Update on the roles of tissue factor in malignant gliomas, including considerations of venous thromboembolism in brain-tumor patients, from …
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FDA approval · 2017-02-27FDA Approved: TEMOZOLOMIDE — Original Application (Accord Healthcare Inc.)
FDA approved an original application for temozolomide by Accord Healthcare Inc., authorizing a generic version of the cancer drug temozolomi…
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: Post-Marketing Surveillance of Gliadel 7.7mg Implant (All-case Observational Study)
A post-marketing all-case observational study of Gliadel wafer (carmustine implant) in malignant glioma has completed, evaluating safety and…
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CLINICAL_TRIALS trial_result · 2017-02-16Clinical Trial Update: A Study Combining LY2157299 With Temozolomide-based Radiochemotherapy in Patients With Newly Diagnosed Malignant Glioma [Phase 1, Phase 2]
This update describes the completion of a Phase 1/2 study evaluating galunisertib (LY2157299) in combination with temozolomide-based radioch…
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CLINICAL_TRIALS trial_result · 2017-02-08Clinical Trial Update: Image Guided Reirradiation of High-grade Glioma [Phase 1, Phase 2]
A phase 1/2 clinical trial of image-guided reirradiation for high-grade glioma has been terminated.
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CLINICAL_TRIALS research · 2016-12-06Clinical Trial Update: CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor [Phase 1, Phase 2]
A Phase 1/2 trial evaluating CAR-pNK cell immunotherapy for MUC1-positive relapsed or refractory solid tumors; current status is not provide…
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CLINICAL_TRIALS trial_result · 2016-11-30Clinical Trial Update: FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas [Phase 1]
Phase 1 trial evaluating fluorodopa (FDOPA) PET/MRI for pre-operative evaluation of gliomas; the study status is terminated.
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CLINICAL_TRIALS trial_result · 2016-11-28Clinical Trial Update: LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluating the combination of panobinostat (LBH589) and bevacizumab in patients with recurrent malignan…
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CLINICAL_TRIALS trial_result · 2016-08-10Clinical Trial Update: Myocet® in Children With Relapsed or Refractory Non-brainstem Malignant Glioma [Phase 1]
Phase 1 trial update reporting completion of a pediatric study of Myocet (liposomal doxorubicin) in children with relapsed or refractory non…
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CLINICAL_TRIALS trial_result · 2016-08-04Clinical Trial Update: Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma [Phase 1]
A Phase 1 study evaluating lomustine for bevacizumab-naive recurrent malignant glioma has been terminated.
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CLINICAL_TRIALS trial_result · 2016-07-28Clinical Trial Update: A Randomized Placebo-Controlled Trial of Armodafinil (Nuvigil) for Fatigue in Patients With Malignant Gliomas [Phase 2]
A Phase 2 randomized, placebo-controlled trial evaluated armodafinil (Nuvigil) for fatigue in patients with malignant gliomas; results have …
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CLINICAL_TRIALS trial_result · 2016-07-18Clinical Trial Update: Comparative 2-D Tumor Analysis in Familial Gliomas
A completed clinical trial report presents results from a comparative 2-D tumor analysis study in patients with familial gliomas.
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CLINICAL_TRIALS trial_result · 2016-07-18Clinical Trial Update: Characterization of Serial Magnetic Resonance Spectroscopy Imaging in Patients With Malignant Glioma Undergoing Radiotherapy
A completed clinical trial update on the characterization of serial MR spectroscopy imaging in patients with malignant glioma undergoing rad…
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CLINICAL_TRIALS trial_result · 2016-05-23Clinical Trial Update: Clinical Study on 5-aminolevulinic Acid Hydrochloride (5-ALA) for Fluorescence-guided Resection of Malignant Gliomas [Phase 1, Phase 2]
Clinical trial update on 5-ALA hydrochloride for fluorescence-guided resection of malignant gliomas (Phase 1/Phase 2), now completed.
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CLINICAL_TRIALS trial_result · 2016-04-15Clinical Trial Update: AMG 595 First-in-Human in Recurrent Gliomas [Phase 1]
Amgen completed a first-in-human Phase 1 trial of AMG 595 in recurrent gliomas to assess safety and early signals of activity. The study inc…
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CLINICAL_TRIALS withdrawal · 2016-03-10Clinical Trial Update: MK-2206 for Recurrent Malignant Glioma [Phase 2]
Phase 2 trial of MK-2206 for recurrent malignant glioma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-02-29Clinical Trial Update: Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma [Phase 2]
This Phase 2 clinical trial update reports results for temozolomide in patients with recurrent glioblastoma multiforme or other malignant gl…
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CLINICAL_TRIALS trial_result · 2016-02-19Clinical Trial Update: Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure [Phase 1]
A Phase 1/2 trial of CTO in combination with Bevacizumab for recurrent malignant glioma after Bevacizumab failure has been terminated.
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CLINICAL_TRIALS trial_result · 2015-12-31Clinical Trial Update: Early-Phase Safety of Proton Therapy Equipment [NA]
This early-phase safety study evaluated proton therapy equipment for treating several cancers and has completed enrollment, with results pos…
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CLINICAL_TRIALS trial_result · 2015-10-29Clinical Trial Update: Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients [Phase 2]
Phase II trial evaluating vorinostat (SAHA) in combination with bevacizumab for recurrent malignant glioma, including glioblastoma. The stud…
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CLINICAL_TRIALS trial_result · 2015-10-14Clinical Trial Update: Imatinib Mesylate, Vatalanib, and Hydroxyurea in Treating Patients With Recurrent or Relapsed Malignant Glioma [Phase 1]
A Phase 1 trial evaluating the combination of imatinib mesylate, vatalanib, and hydroxyurea in patients with recurrent or relapsed malignant…
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CLINICAL_TRIALS trial_result · 2015-10-05Clinical Trial Update: Vaccine Therapy in Treating Patients With Malignant Glioma [Phase 1]
Phase 1 trial evaluating a vaccine therapy for malignant glioma has completed.
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CLINICAL_TRIALS trial_result · 2015-08-19Clinical Trial Update: Safety Study of AP23573 in Patients With Progressive or Recurrent Glioma (8669-023)(COMPLETED) [Phase 1]
A Phase 1 safety study of ridaforolimus (AP23573) in patients with progressive or recurrent glioma has completed, including glioblastoma and…
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CLINICAL_TRIALS research · 2015-07-14Clinical Trial Update: Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas [Phase 4]
Phase 4 trial assessing cytokine-induced killer cells for advanced malignant gliomas; the study is currently not recruiting.
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CLINICAL_TRIALS research · 2015-07-10Clinical Trial Update: Effect of Cytokine-induced Killer Cells for Stage I-II Malignant Gliomas [Phase 1, Phase 2]
A Phase 1/Phase 2 trial is evaluating cytokine-induced killer (CIK) cells for treating stage I-II malignant gliomas; the study is currently …