Major Depressive Disorder
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Avatar Therapy in Virtual Reality for Treatment-Resistant Major Depressive Disorder: A Pilot Study [NA]
This document provides an update on a pilot study of avatar therapy in virtual reality for treatment-resistant major depressive disorder, wi…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients [Phase 2]
This clinical trial update reports that a Phase 2 study is evaluating ketamine infusions to treat depression in ICU patients, with recruitme…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: 5-HTP and Creatine for Depression R33 Phase [Phase 2]
Clinical trial update for a Phase 2 study (R33) evaluating 5-HTP and creatine for major depressive disorder; recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Brief Cognitive Behavioral Therapy for Reducing Suicidal Ideation in Economically Distressed Migrants [NA]
A completed clinical trial evaluating brief cognitive behavioral therapy to reduce suicidal ideation in economically distressed migrants.
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Neuromodulation and Attention Deficits in MDD [NA]
A neuromodulation study from the University of Electronic Science and Technology of China is recruiting to address attention deficits in ind…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: "Culturally Adapted CBT for Depression in Arab and Asian Adolescents in the UAE (CA-CBT)" [NA]
The CA-CBT trial evaluating culturally adapted cognitive-behavioral therapy for depression in Arab and Asian adolescents in the UAE has comp…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Poststroke Depression in Hemorrhagic Stroke [Phase 2]
Phase 2 trial investigating post-stroke depression in patients with hemorrhagic stroke has completed and posted results as of 2025-08-06.
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: A Study to Test Different Doses of BI 1569912 in People With Depression [Phase 2]
Phase 2 trial evaluating different doses of BI 1569912 in adults with major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: The Sugira Muryango Longitudinal & Spillover Study
A completed longitudinal and spillover clinical trial sponsored by Boston College evaluating cognitive change, growth and nutritional outcom…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Clonidine to Prevent Delirium After Electroconvulsive Therapy. [Phase 4]
Phase 4 clinical trial evaluating clonidine to prevent delirium after electroconvulsive therapy; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: COMpassion for Psychiatric Disorders And Self-Stigma [NA]
A clinical trial update for the COMpassion for Psychiatric Disorders And Self-Stigma study conducted by University Hospital Strasbourg, curr…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Mental Health in Primary Care [NA]
Ongoing University of Miami clinical trial in primary care assessing depression, anxiety, suicidality, and substance use; currently recruiti…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: A Hybrid Psychological Intervention for Depression in Adolescents [NA]
A clinical trial evaluating a hybrid psychological intervention for adolescent depression has completed, sponsored by The First Hospital of …
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
A two-year study evaluating vagus nerve stimulation for higher-grade treatment-resistant depression reports clinical outcomes and includes a…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: taVNS or TMS or Both for Depression [NA]
This update indicates that a study is recruiting to assess taVNS or transcranial magnetic stimulation (TMS), alone or in combination, for de…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans [Phase 1]
Yale University is conducting a fixed-order, open-label, dose-escalation Phase 1 trial of dimethyltryptamine (DMT). The study targets indivi…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: Mobile-Phone-Based Psychoeducation for Dementia Caregivers in Vietnam [NA]
Completed clinical trial in Vietnam evaluating a mobile phone-based psychoeducation program for dementia caregivers to reduce depression, an…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia [NA]
This is a clinical trial update describing a study that combines EMDR therapy with transcranial direct current stimulation (tDCS) for fibrom…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics
Mayo Clinic is conducting a multi-omic, clinomic, and digitomic study of major depressive disorder to enable integrative analytics; the tria…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: The Effect of Oral Bifidobacterium on Exogenous Creatine Absorption in Adult Subjects [NA]
A completed clinical trial evaluated whether an oral Bifidobacterium probiotic affects the absorption of exogenous creatine in adults with d…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: A Phase 2 Study to Evaluate Efficacy and Safety of KH607 Tablets in Adult Participents With Major Depressive Disorder [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy and safety of KH607 tablets for adults with Major Depressive Disorder, with the study cu…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Esketamine and Perioperative Depressive Symptoms [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating esketamine for perioperative depressive symptoms has completed.
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Chart Review of Patients Undergoing Ketamine Treatments for Depression
A completed chart-review study examining outcomes for patients with major depressive disorder who underwent ketamine treatments for depressi…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Behavior, Biology and Well-Being Study [NA]
Completed clinical trial update from University of Wisconsin–Madison on the Behavior, Biology and Well-Being Study; results have been posted…
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FDA approval · 2025-07-31FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
The FDA approved Janssen's supplemental application for SPRAVATO (esketamine hydrochloride), updating its labeling to reflect the approved s…