Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study [NA]
ClinicalTrials.gov update describes a study of self-help Cognitive Processing Therapy combined with the Women Veterans Network for posttraum…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression [NA]
Clinical trial evaluating virtual reality-based mindfulness as an adjunct to treatment as usual for treatment-resistant depression. The stud…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Accelerated TMS for Depression and OCD [NA]
Clinical trial evaluating accelerated transcranial magnetic stimulation for depression and obsessive-compulsive disorder is currently recrui…
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CLINICAL_TRIALS other · 2026-02-27Clinical Trial Update: Identifying the Neural Basis of Capability for Suicide
A clinical trial update indicates a study examining the neural basis of capability for suicide has been suspended, involving participants wi…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction [NA]
The Sleep and Light Intervention (SALI) trial at the University of California, San Diego is evaluating a sleep and light therapy for menopau…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Health Questionnaire Study [NA]
University of California, Irvine is conducting a health questionnaire study related to depression and anxiety that is currently active but n…
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FDA approval · 2026-02-25FDA Approved: BUPROPION HYDROCHLORIDE — Supplemental Application (Apnar Pharma LP)
FDA approved a supplemental application for bupropion hydrochloride from Apnar Pharma LP, granting approval for the supplemental use of this…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Determine the Bioavailability of Selegiline TDS 6mg/24 Hours vs EMSAM in Healthy Subjects
A Phase 1 bioavailability study comparing Selegiline Transdermal System 6 mg/24 hours with EMSAM in healthy subjects has completed.
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant [Phase 4]
Phase 4 trial comparing methotrexate alone versus methotrexate plus an antidepressant for patients with psoriasis and comorbid depression or…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Biomarker-guided rTMS for Treatment Resistant Depression [Phase 3]
Phase 3 clinical trial investigating biomarker-guided repetitive transcranial magnetic stimulation for treatment-resistant depression is cur…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: ROOM-LIGHT: Effect of a Dynamic Lighting System in Depressed Inpatients [NA]
The ROOM-LIGHT trial evaluated a dynamic lighting system for inpatients with major depressive disorder. The study has completed.
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CLINICAL_TRIALS withdrawal · 2026-02-25Clinical Trial Update: Repeated Neurocognitive Measurements in Depressed Patients [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial evaluating repeated neurocognitive measurements in patients with major depressive disorder has been withdra…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards [NA]
The ROOM-LIGHT trial evaluated dynamic LED-light therapy as a treatment for depressed inpatients; the study has completed.
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: The Advance Project - Advancing Sleep Timing to Improve Depression [NA]
This update describes a clinical trial exploring whether advancing sleep timing can improve depressive symptoms, sponsored by University Hos…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Electronic Self-monitoring on Regulation of the Sleep-wake Cycle to Reduce Relapse of Depression After Discharge [NA]
The clinical trial evaluating electronic self-monitoring of the sleep-wake cycle to reduce relapse of depression after discharge has complet…
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CLINICAL_TRIALS withdrawal · 2026-02-25Clinical Trial Update: Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS) [NA]
Clinical trial MOODDIS assessing hedonic and motivational states in major depression has been withdrawn.
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
This clinical trial update describes a study examining how lithium impacts the brain's functional and structural connectome in treating bipo…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial [NA]
This clinical trial update describes a study comparing imaging-targeted versus scalp-targeted accelerated transcranial magnetic stimulation …
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic [NA]
This clinical trial update describes The Exhale Study, an ongoing investigation into treating maternal depression in an urban pediatric asth…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Parent-Adolescent Relationships, Emotional Regulation, and HRV in Adolescents With Depression
The study investigates how parent-adolescent relationships and emotional regulation relate to heart rate variability in adolescents with dep…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE [NA]
This ClinicalTrials.gov entry indicates that the ENHANCE-EvideNce Led Co-created Health Systems interventions for MLTCs Care trial conducted…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Personalized Brain Stimulation to Treat Chronic Concussive Symptoms [Phase 2]
Phase 2 clinical trial investigating personalized brain stimulation to treat chronic concussion symptoms is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression [Phase 1]
A Phase 1 clinical trial is exploring the mechanism by which ketamine may exert antidepressant effects in treatment-resistant major depressi…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Lonely in Depression
A clinical trial from Friedrich-Alexander-Universität Erlangen-Nürnberg is currently recruiting to study loneliness in individuals with depr…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) [Phase 4]
A Phase 4 clinical trial from Mayo Clinic is evaluating whether RNA editing can serve as a biomarker to predict antidepressant response in a…