Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression [EARLY_Phase 1]
This is an early-phase randomized pilot study evaluating repetitive transcranial magnetic stimulation (rTMS) for knee osteoarthritis pain wi…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Pilot Study of the Parental Friendship Coaching+ Program for Families of Children With Attention-deficit/Hyperactivity Disorder [NA]
Pilot study of a Parental Friendship Coaching+ program for families of children with ADHD has completed. The trial did not involve a pharmac…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Digital Interventions for Relapse Prevention in Adolescence [NA]
University of Oslo is conducting a clinical trial of digital interventions to prevent relapse in adolescents with major depressive disorder …
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FDA approval · 2026-03-13FDA Approved: CITALOPRAM — Original Application (Aurobindo Pharma Limited)
FDA approved the original ANDA for a generic citalopram product from Aurobindo Pharma Limited.
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Effect of the MindUP Program on Depression, Anxiety, and Stress in Pakistani Orphan Adolescents [NA]
A completed trial evaluating whether the MindUP program reduces depression and anxiety (and stress) symptoms in Pakistani orphan adolescents…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Genetic and Neural Predictors of Adolescent Depression
A completed clinical trial investigated genetic and neural predictors of adolescent depression. The study, sponsored by McLean Hospital, foc…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Safety and Tolerability of Zelquistinel in Normal Human Volunteers [Phase 1]
Phase 1 study evaluating the safety and tolerability of Zelquistinel in healthy volunteers has completed. The trial lists Major Depressive D…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Behavioral Health Collaborative Care Model in an ICU Recovery Clinic [NA]
A clinical trial is evaluating a Behavioral Health Collaborative Care Model in an ICU recovery clinic, with recruitment currently ongoing.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans [NA]
A clinical trial is recruiting to study neural mechanisms of repetitive brain stimulation using invasive and noninvasive electrophysiology i…
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CLINICAL_TRIALS withdrawal · 2026-03-12Clinical Trial Update: Lifestyle MIND- Feasibility of Wait-list Control [NA]
A feasibility trial of a Lifestyle MIND intervention for individuals with Type 2 diabetes mellitus and serious mental illness (including sch…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot [NA]
The trial is recruiting at the Medical University of South Carolina for a Behavioral Health Collaborative Care Model in a post-ICU clinic fa…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure [Phase 3]
A Phase 3 trial assessing Aticaprant plus an antidepressant to prevent relapse of depressive symptoms in adults with major depressive disord…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures [Phase 4]
A Phase 4 clinical trial is evaluating a serotonin-norepinephrine reuptake inhibitor for preventing depression after fragility fractures in …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
A National Institute of Mental Health study is conducting a prospective natural history study of motor activity and mood states in bipolar d…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Concurrent TMS-fMRI [NA]
A clinical trial entry notes ongoing recruitment for concurrent transcranial magnetic stimulation (TMS) with fMRI in healthy controls and in…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2 [NA]
A clinical trial update for NCT05267340 describes an MRI connectome study of meditation training effects on brain networks in healthy and de…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Acupuncture and Escitalopram for Treating Major Depression Clinical Study [NA]
This clinical trial update describes a study evaluating the combination of acupuncture and escitalopram for major depressive disorder, which…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Perinatal Research on Improving Sleep and Mental Health [NA]
Clinical trial update from UCSF describing perinatal research to improve sleep and mental health, focusing on insomnia and depression; the s…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) [Phase 3]
This document describes a Phase 3 long-term extension trial (EXTEND) to evaluate the safety and efficacy of CYB003 in major depressive disor…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth [Phase 3]
A Phase 3 clinical trial is evaluating prefrontal glutamatergic modulation with N-acetylcysteine (NAC) and mindfulness-based cognitive thera…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study of Vortioxetine in Japanese Pediatric Patients With Major Depressive Disorder [Phase 3]
A Phase 3 clinical trial evaluating vortioxetine in Japanese pediatric patients with major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Open-Label Psilocybin Study in Transdiagnostic Population [Phase 1]
Open-label Phase 1 trial of psilocybin in a transdiagnostic population. The study targets major depressive disorder, anxiety disorders, post…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression [NA]
This clinical trial update reports a Florida State University-sponsored study investigating the causal role of delta-beta coupling in goal-d…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety [NA]
An update on a clinical trial evaluating low-intensity focused ultrasound as a treatment for depression. The study is sponsored by Ocean Sta…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk [NA]
An ongoing study is evaluating accelerated intermittent theta burst stimulation as a treatment for adolescent and young adult depression wit…