Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE) [Phase 2]
An open-label Phase 2 safety study of AXS-05 in treatment-resistant depression and major depressive disorder was terminated, with results po…
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Pilot Testing a Virtual Mindfulness-Based Intervention to Improve Veterans' Health [NA]
A pilot trial evaluated a virtual mindfulness-based intervention to improve health outcomes in veterans with depression, with results posted…
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression [NA]
Clinical trial update on whether esketamine reduces perioperative negative emotions in breast cancer surgery patients with severe depression…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Parenting Young Children Study [NA]
A completed clinical trial from the University of Oregon evaluating parenting interventions for families affected by opioid misuse and relat…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: GLP-1 Medicines and Mental Health Changes [NA]
A completed UC San Diego‑sponsored clinical trial evaluated GLP-1 medicines and their effects on mental health in people with obesity and de…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: To Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Food Effects of LY03021 in Healthy Chinese Subjects [Phase 1]
Phase 1 clinical trial assessing safety, tolerability, pharmacokinetics, and food effects of LY03021 in healthy Chinese subjects, with Major…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse [Phase 4]
Clinical trial update on lumateperone as adjunctive therapy for major depressive disorder in patients with early life trauma.
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Testing Feasibility of Care Coordination and Motivational Interviewing for Women With a Recent Preterm Birth [NA]
Terminated clinical trial evaluating care coordination and motivational interviewing for women with a recent preterm birth; results have bee…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: The Role of Social Determinants in Cardiovascular Health and Vascular Function [NA]
A completed Baylor Research Institute clinical trial examined how social determinants of health influence cardiovascular health and vascular…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 Pandemic [NA]
Completed clinical trial evaluating a telehealth cognitive remediation intervention to address poor decision-making and depression in vetera…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: The Study of Internet-delivered, Transdiagnostic Treatments for Anxiety and Depression [NA]
The completed study evaluated internet-delivered, transdiagnostic treatments for anxiety and depression. It was sponsored by Stockholm Unive…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Tianeptine for Treatment Resistant Depression [Phase 4]
Phase 4 trial update for tianeptine in treatment-resistant depression was terminated, with results posted in January 2026.
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: VOICES Socials for Older Veterans With Depression [NA]
The VOICES Socials trial for older veterans with depression has completed, evaluating a social-engagement program to address depression, lon…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Cannabinoids as a Treatment for Insomnia in Major Depression [Phase 2]
Phase 2 trial evaluating cannabinoids for insomnia in adults with major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: A Neurosteroid Intervention for Menopausal and Perimenopausal Depression [Phase 1, Phase 2]
This clinical trial update reports results from a phase 1/2 study evaluating a neurosteroid intervention for major depressive disorder assoc…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: The Antidepressant Effect of Intermittent Theta Burst Stimulation (iTBS) [NA]
A clinical trial update noting the completion of a study evaluating intermittent theta burst stimulation as an antidepressant treatment for …
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Study on Allopregnanolone and Depression in Perimenopausal Women [Phase 4]
This update reports on a Phase 4 trial evaluating allopregnanolone for depression in perimenopausal women. The study was terminated and resu…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Flywheel Resistance Training and Traditional Resistance Training in Older Women With Sedentary Behaviors [NA]
Completed study comparing flywheel resistance training with traditional resistance training in sedentary older women, assessing depressive s…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor(SPEAC) for Adults With Emotional Distress (Phase 2) [NA]
Phase 2 trial evaluating a PST-trained voice-enabled AI counselor (SPEAC) for adults with emotional distress has completed, studying Depress…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Feasibility of CALM Therapy in Korean Cancer Patients [NA]
Completed clinical trial evaluating the feasibility of CALM Therapy for depression in Korean cancer patients.
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Self-Affirmation Intervention After Mastectomy [NA]
A self-affirmation intervention trial for patients after mastectomy due to breast cancer is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Intervention Effect of High Definition Transcranial Alternating Current Stimulation (HD-tACS) on Depressive Disorder [NA]
A completed clinical trial evaluated the effect of high-definition transcranial alternating current stimulation (HD-tACS) on depressive diso…
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: Probiotics Regulate Intestinal Health and Alleviate Anxiety [NA]
A completed clinical trial sponsored by Wecare Probiotics evaluated whether a probiotic product can regulate intestinal health and alleviate…
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: Online Cognitive Behavioral Therapy (CBT) for Stress Disorders in Health Workers Involved in the Care of Patients During the Covid-19 Epidemic [NA]
A completed clinical trial evaluated online cognitive behavioral therapy to prevent sleep disorders, PTSD, and depression in health workers …
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia [Phase 4]
Phase 4 study evaluating valbenazine for tardive dyskinesia in participants with schizophrenia, schizoaffective disorder, bipolar disorder, …