Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Minocycline as Adjunctive Treatment for Treatment Resistant Depression [Phase 3]
A Phase 3 clinical trial evaluating minocycline as an adjunctive treatment for treatment-resistant depression has completed.
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Comparing Effect and Change Processes in Cognitive Behavioral Therapy and Emotion-Focused Therapy for Depression [NA]
Completed clinical trial comparing effect and change processes in Cognitive Behavioral Therapy and Emotion-Focused Therapy for Depression. T…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Appalachian Mind Health Initiative [NA]
The Appalachian Mind Health Initiative clinical trial for Major Depressive Disorder has completed.
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Alexithymia Intervention for Suicide [Phase 1]
Phase 1 trial of an alexithymia intervention for suicide risk was terminated.
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: SMILE Trial - Imaging Sub-Study
This clinical trial update reports the completion of the imaging sub-study within the SMILE trial for Major Depressive Disorder, sponsored b…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: A Graphene Far-infrared Intervention Study of Cognitive Status in Older Adults [NA]
Completed clinical trial evaluating a graphene-based far-infrared intervention on cognitive status in older adults, including individuals wi…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study) [Phase 2]
This is an open-label extension study in Phase 2 evaluating the safety and tolerability of SPT-300 (GlyphAllo) in adults with major depressi…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Internet-based Mindfulness-based Training (iMBT) for People With Depression [NA]
This entry reports the completion of a clinical trial evaluating Internet-based Mindfulness-based Training (iMBT) for people with depression…
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms [NA]
A completed trial evaluated the effectiveness of a smartphone-delivered cognitive behavioral therapy program for adults with psoriasis and c…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder [Phase 2]
Phase 2 study of CLE-100, an oral esketamine, as an adjunct to standard antidepressants for major depressive disorder, has completed its tri…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder [NA]
A completed clinical trial update on optimizing transcranial direct current stimulation (tDCS) protocol for major depressive disorder.
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
An update on a clinical trial studying multi-omics and AI-based prediction to optimize antidepressant efficacy in major depressive disorder.…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Anhedonia, Development, and Emotions: Phenotyping and Therapeutics [Phase 4]
Phase 4 clinical trial update examining anhedonia, development, and emotions, including phenotyping and therapeutic approaches; results have…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder [Phase 2]
Phase 2 clinical trial update evaluating psilocybin for major depressive disorder with co-occurring alcohol use disorder, sponsored by Johns…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: African Youth in Mind (Y-MIND) - Pilot Feasibility Trial of a Brief Psychological Intervention for Young People With Depression in Zimbabwe [NA]
Update on a pilot feasibility trial (Y-MIND) evaluating a brief psychological intervention for depression among young people in Zimbabwe; th…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: CBT+ for Depression [NA]
The study evaluating CBT+ for Major Depressive Disorder has completed; the update does not include results.
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge) [Phase 3]
MM120's Phase 3 trial for major depressive disorder is currently active but not recruiting. The trial is sponsored by Definium Therapeutics …
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Pilot Study of the Parental Friendship Coaching+ Program for Families of Children With Attention-deficit/Hyperactivity Disorder [NA]
Pilot study of a Parental Friendship Coaching+ program for families of children with ADHD has completed. The trial did not involve a pharmac…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Effect of the MindUP Program on Depression, Anxiety, and Stress in Pakistani Orphan Adolescents [NA]
A completed trial evaluating whether the MindUP program reduces depression and anxiety (and stress) symptoms in Pakistani orphan adolescents…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Genetic and Neural Predictors of Adolescent Depression
A completed clinical trial investigated genetic and neural predictors of adolescent depression. The study, sponsored by McLean Hospital, foc…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Safety and Tolerability of Zelquistinel in Normal Human Volunteers [Phase 1]
Phase 1 study evaluating the safety and tolerability of Zelquistinel in healthy volunteers has completed. The trial lists Major Depressive D…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure [Phase 3]
A Phase 3 trial assessing Aticaprant plus an antidepressant to prevent relapse of depressive symptoms in adults with major depressive disord…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures [Phase 4]
A Phase 4 clinical trial is evaluating a serotonin-norepinephrine reuptake inhibitor for preventing depression after fragility fractures in …
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CLINICAL_TRIALS trial_result · 2026-03-10Clinical Trial Update: Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts [NA]
A completed ClinicalTrials.gov update from Massachusetts General Hospital reports results posted for a trial evaluating attentional and cogn…
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CLINICAL_TRIALS trial_result · 2026-03-10Clinical Trial Update: New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD) [NA]
A completed Brainsway-sponsored clinical trial evaluating a new brain stimulation protocol for Major Depressive Disorder.