Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2022-08-25Clinical Trial Update: Treatment of Depression With Connectivity Guided Robotically Delivered rTMS [NA]
Clinical trial update for a study on connectivity-guided robotically delivered rTMS in major depressive disorder; study status terminated wi…
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CLINICAL_TRIALS trial_result · 2022-08-22Clinical Trial Update: An EEG Study of Intravenous Ketamine for Major Depression Disorder [Phase 4]
Clinical trial update for intravenous ketamine in major depressive disorder (Phase 4) with unknown status.
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CLINICAL_TRIALS trial_result · 2022-08-19Clinical Trial Update: A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder [Phase 2]
Phase 2 clinical trial update for PRAX-114 as adjunctive and monotherapy in major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2022-08-16Clinical Trial Update: A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy [Phase 2]
Phase 2 trial comparing JNJ-42847922 to quetiapine extended-release as adjunctive therapy to antidepressants in adults with major depressive…
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CLINICAL_TRIALS trial_result · 2022-08-08Clinical Trial Update: Vortioxetine in Patients With Depression and Early Dementia [Phase 4]
Phase 4 clinical trial update of vortioxetine in patients with major depressive disorder and dementia completed.
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CLINICAL_TRIALS trial_result · 2022-08-08Clinical Trial Update: BRITEPath, Component 3 of iCHART (Integrated Care to Help At-Risk Teens) [NA]
A completed trial update for BRITEPath, part of iCHART, studying depression and suicidal ideation in at-risk teens; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-08-02Clinical Trial Update: Zelquistinel in the Treatment of Major Depressive Disorder [Phase 2]
A Phase 2 trial evaluating Zelquistinel for major depressive disorder has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2022-07-27Clinical Trial Update: Prophylactic Effects of Agomelatine for Poststroke Depression [Phase 4]
Phase 4 trial update investigating prophylactic effects of agomelatine for post-stroke depression.
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CLINICAL_TRIALS trial_result · 2022-07-21Clinical Trial Update: A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder [Phase 2, Phase 3]
Clinical trial update for PRAX-114 in participants with Major Depressive Disorder (Phase 2/Phase 3) completed.
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CLINICAL_TRIALS trial_result · 2022-07-18Clinical Trial Update: Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study [NA]
A completed pilot study evaluating development, feasibility, and acceptability of the Fathers and Babies (FAB) program for perinatal and pos…
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CLINICAL_TRIALS trial_result · 2022-07-12Clinical Trial Update: Mechanistic Evaluation of Response in TRD (MERIT) [Phase 2]
Phase 2 clinical trial evaluating mechanistic response in treatment resistant depression and major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2022-07-06Clinical Trial Update: iTBS Study for Depression (Randomized) [NA]
A completed randomized trial evaluating iTBS for depression and executive dysfunction with results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-07-05Clinical Trial Update: miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome [Phase 2]
Phase 2 clinical trial investigating plasma exosomal microRNAs as biomarkers for suicidality and treatment outcome in major depressive disor…
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CLINICAL_TRIALS trial_result · 2022-06-22Clinical Trial Update: Antidepressant Trial With P2X7 Antagonist JNJ-54175446 [Phase 2]
Phase 2 trial update for JNJ-54175446 (P2X7 antagonist) in major depressive disorder with inflammation; current status is unknown.
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CLINICAL_TRIALS trial_result · 2022-06-16Clinical Trial Update: Study to Evaluate the Efficacy of LABCAT TCJUSS in Patients With Depressive Episode [Phase 3]
Phase 3 clinical trial evaluating LABCAT TCJUSS for depressive episode was terminated.
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CLINICAL_TRIALS trial_result · 2022-06-02Clinical Trial Update: Outcomes Mandate National Integration With Cannabis as Medicine [Phase 2]
Phase 2 clinical trial update focusing on integrating cannabis as medicine for various chronic pain conditions, with status currently UNKNOW…
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CLINICAL_TRIALS trial_result · 2022-06-02Clinical Trial Update: Treatments for Improving Mood in Depressed Teens-3 [NA]
A completed clinical trial investigating treatments for improving mood in depressed teens; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-06-02Clinical Trial Update: Advancing Personalized Antidepressant Treatment Using PET/MRI [Phase 4]
Phase 4 clinical trial updating personalized antidepressant treatment using PET/MRI in depression has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-05-31Clinical Trial Update: Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females [Phase 4]
Phase 4 randomized trial evaluating placebo-controlled augmentation with 5-hydroxytryptophan and creatine in women with treatment-resistant …
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CLINICAL_TRIALS trial_result · 2022-05-24Clinical Trial Update: A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression [Phase 3]
Phase 3 study evaluating the efficacy, pharmacokinetics, safety and tolerability of flexible doses of intranasal esketamine plus an oral ant…
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CLINICAL_TRIALS trial_result · 2022-05-24Clinical Trial Update: Optimizing Outcomes of Treatment-Resistant Depression in Older Adults [Phase 4]
Phase 4 trial update evaluating outcomes for treatment-resistant depression in older adults; results were posted in May 2022.
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CLINICAL_TRIALS trial_result · 2022-05-17Clinical Trial Update: Inflammation-related Alterations in Neurocircuitry: Reversal With Levodopa [Phase 4]
Phase 4 trial investigating whether Levodopa reverses inflammation-related neurocircuitry alterations associated with depression; study comp…
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CLINICAL_TRIALS trial_result · 2022-05-17Clinical Trial Update: Scaling Up Science-based Mental Health Interventions in Latin America [NA]
Completed clinical trial evaluating science-based mental health interventions in Latin America addressing depression and problematic alcohol…
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CLINICAL_TRIALS trial_result · 2022-05-12Clinical Trial Update: Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder. [Phase 2]
Phase 2 trial comparing memory effects of gamma-hydroxybutyrate versus trazodone in major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2022-05-12Clinical Trial Update: Tracking Depression Symptoms With a Health Chatbot [NA]
Completed clinical trial evaluating a health chatbot for tracking depression symptoms.