Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disorder [Phase 1]
A Phase 1 study evaluating the effects of single-dose and repeat-administration intranasal esketamine on on-road driving performance in adul…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study to Investigate the Safety, Tolerability, and Pharmacodynamics of JNJ-54175446 in Participants With Major Depressive Disorder [Phase 1]
A Phase 1 study assessing safety, tolerability, and pharmacodynamics of JNJ-54175446 in adults with Major Depressive Disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder [Phase 1]
This Phase 1 study has completed. It evaluated oral Seltorexant as an add-on to antidepressant therapy to assess on-road driving performance…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy [Phase 1]
Phase 1 study evaluating Seltorexant as an add-on to antidepressants in adolescents with major depressive disorder who had an inadequate res…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD)
This completed clinical trial evaluated the performance validity and test-retest reliability of a computer-administered cognitive test batte…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disorder [Phase 1]
This update covers a Phase 1 safety, efficacy and biomarker study of JNJ-42847922 in people with major depressive disorder, which has comple…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: MRI-Guided High-Definition Transcranial Direct Current Stimulation (tDCS) for Depression [NA]
This clinical trial update reports the completion of a study evaluating MRI-guided high-definition transcranial direct current stimulation f…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant
A standard-of-care study in adults with major depressive disorder has been terminated after inadequate response to an SSRI/SNRI antidepressa…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress [NA]
Completed clinical trial evaluating an AI-informed intervention (Emohaa) vs Group ACT vs waitlist on emotional distress, with conditions inc…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Affect Treatment for Depression and Anxiety [NA]
A UCLA-sponsored clinical trial investigating a treatment for depression and anxiety has completed.
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: Post-Stroke Optimization of Walking Using Explosive Resistance [Phase 2]
Phase 2 trial evaluating explosive-resistance training to improve walking after stroke; results were posted in April 2025.
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: LSD Therapy for Persons Suffering From Major Depression [Phase 2]
A Phase 2 clinical trial evaluating LSD-based therapy for major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: A Study to Evaluate Efficacy and Safety of GW117 Tablets in Major Depressive Disorder [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of GW117 tablets for major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-04-22Clinical Trial Update: Neuroinflammation in COVID-19 and Depression
A clinical trial investigating neuroinflammation in patients with COVID-19 and major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-04-22Clinical Trial Update: Microglial Activation in Inflammatory Bowel Disease
This clinical trial update reports on microglial activation in inflammatory bowel disease and its relation to major depressive episodes, wit…
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CLINICAL_TRIALS trial_result · 2025-04-18Clinical Trial Update: Psychological Effect of Explicit Recall After Sedation (PEERS)
The PEERS trial (NCT04747379) examining the psychological effect of explicit recall after sedation has completed. The study addresses awaren…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: The Lived Experiences Measured Using Rings Pilot Study [Phase 2]
The University of Vermont-conducted Phase 2 pilot study on lived experiences related to depression, stress, sleep, and anxiety has completed…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers [EARLY_Phase 1]
A Phase 1 study of Ketamine-assisted Psychotherapy for existential distress in patients with non-operable gastrointestinal cancers was termi…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Living Well: A Digital ACT Intervention [NA]
Complete update on a clinical trial of Living Well, a digital ACT intervention. The study targeted depressive symptoms and anxiety.
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program [NA]
This clinical trial update notes ongoing recruitment for a program aimed at improving identity and coping skills to address chronic stress, …
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CLINICAL_TRIALS trial_result · 2025-04-15Clinical Trial Update: Income Volatility and Mental Health, Pilot Study [NA]
Pilot study results examining the relationship between income volatility and depressive symptoms have been completed and results posted.
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CLINICAL_TRIALS trial_result · 2025-04-15Clinical Trial Update: Mobile Transcranial Magnetic Stimulation [NA]
A completed clinical trial evaluating mobile transcranial magnetic stimulation for depression, sponsored by the University of Regensburg.
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CLINICAL_TRIALS trial_result · 2025-04-13Clinical Trial Update: The Utility of Concurrent TBS/fNIRS for Antidepressant Treatment Optimization [NA]
A completed clinical trial evaluating concurrent TBS and fNIRS for optimizing antidepressant treatment in Major Depressive Disorder.
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: Friendship Bench Mental Health Intervention for Adolescent Girls and Young Women in South African PrEP Delivery Settings [NA]
Completed clinical trial of the Friendship Bench mental health intervention for adolescent girls and young women in South Africa within PrEP…
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression [NA]
This clinical trial update reports on the clinical effectiveness of the TARA therapy versus standard treatment for depression in adolescents…