Major Depressive Disorder
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy [Phase 3]
Phase 3 study evaluating seltorexant as an adjunctive therapy to antidepressants in adults and elderly patients with major depressive disord…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Psychotherapy Feasibility Pilot of the Carolina Recovery From Depression Protocol [NA]
A completed clinical trial evaluating the feasibility of the Carolina Recovery From Depression Protocol, a psychotherapy program for unipola…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: A Feasibility Study to Determine Whether the Botanical Garden Become a Region of Forest Therapy for Cancer Survivors [NA]
This completed feasibility study evaluated whether converting a botanical garden into a forest therapy region could benefit cancer survivors…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: A Tripartite Biopsychosocial Intervention Program Enhances Mental Health and Quality of Life in Elderly Patients With Depression Secondary to Geriatric Diseases [NA]
A completed clinical trial evaluating a tripartite biopsychosocial intervention shows improvements in mental health and quality of life amon…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression [NA]
Completed clinical trial assessing how social reward affects brain function during psychotherapies for mid- and late-life major depressive d…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Change in Social Media Use and Well-being Among College Students Receiving a One-week Exercise or Mindfulness Intervention [NA]
This completed clinical trial evaluated how a one-week exercise or mindfulness intervention affected social media use and well-being in coll…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression [Phase 4]
Phase 4 trial evaluating the efficacy and safety of toludesvenlafaxine hydrochloride extended-release tablets in somatic symptoms of depress…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Mindfulness-based Stress Reduction Effects on Depression, Anxiety and Internalized Stigma Compared With Treatment-As-Usual Among Head and Neck Cancer Patients [NA]
A completed clinical trial compares mindfulness-based stress reduction with treatment-as-usual to assess effects on depression, anxiety, and…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop [NA]
A multisite randomized controlled trial evaluating STEP-Home, a transdiagnostic skill-based community reintegration workshop for individuals…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study [NA]
A completed pilot trial (STRIDE) evaluated a supervised treadmill exercise program to reduce inflammation and depressive symptoms in people …
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 clinical trial evaluating centanafadine as monotherapy or as an SSRI adjunct in adults with major depressive disorder has complete…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo [Phase 2]
Phase 2 trial in major depressive disorder comparing NMRA-335140 (BTRX-335140) to placebo has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression [NA]
Completed clinical trial evaluating closed-loop transcranial alternating current stimulation for depression with results posted in 2025.
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Therapist-Guided Smartphone-Delivered CBT for MDD [NA]
A completed clinical trial evaluated therapist-guided cognitive behavioral therapy delivered via a smartphone for Major Depressive Disorder.…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Caregiver Depression in a Low-Resource Setting: Socio-Demographic Predictors of Major Depressive Disorder Among Family Caregivers of Breast Cancer Patients in Pakistan
A completed clinical trial from Rahmah Health Foundation investigating socio-demographic predictors of major depressive disorder among famil…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: PDA for Antidepressant Use in Pregnancy [NA]
A clinical trial evaluating a patient decision aid for antidepressant use during pregnancy has completed.
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Personalized Prevention of Depression in Primary Care [NA]
This clinical trial update notes that the study on personalized prevention of depression in primary care has completed.
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Online MBCT vs HEP for Depressive Symptoms in Older Adults: RCT [NA]
A completed randomized controlled trial comparing online Mindfulness-Based Cognitive Therapy to a health education program for depressive sy…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial [NA]
An exploratory trial evaluating combined rTMS and tDCS for major depressive disorder, including treatment-resistant depression, has been ter…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study [NA]
The EMBRACE study evaluating reimagined antenatal care for mothers and babies has completed, with outcomes involving premature birth and mat…
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CLINICAL_TRIALS trial_result · 2025-05-21Clinical Trial Update: Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease [NA]
Completed clinical trial from the University of North Carolina investigated central neurophysiologic correlates of non-motor symptoms in Par…
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CLINICAL_TRIALS trial_result · 2025-05-20Clinical Trial Update: Targeting IL-17A for Treatment-Resistant Depression [Phase 2]
Phase 2 trial investigating an IL-17A-targeting therapy for treatment-resistant depression has completed and posted results.
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CLINICAL_TRIALS trial_result · 2025-05-20Clinical Trial Update: Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression [NA]
A completed clinical trial evaluated adding delta-beta transcranial alternating current stimulation (tACS) to single-session Behavioral Acti…
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CLINICAL_TRIALS trial_result · 2025-05-18Clinical Trial Update: DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis
This entry describes the DIALOG study, a language-focused global initiative in psychosis led by Douglas Mental Health University Institute. …
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy
A completed clinical trial evaluating salivary oxytocin as a biomarker in psychedelic-assisted psychotherapy for depression and anxiety.