Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT) [NA]
The BE WITH Project, a partially nested randomized controlled trial in older adults focused on depression and related mental health outcomes…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: Digital Support for Mental Health Intervention in Patients With Inflammatory Bowel Disease [NA]
A completed clinical trial evaluated a digital mental health support intervention for patients with inflammatory bowel disease, focusing on …
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy [Phase 3]
Phase 3 study evaluating aticaprant as an adjunctive therapy for adults with major depressive disorder and moderate-to-severe anhedonia; the…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD [Phase 3]
A randomized, double-blind, placebo-controlled Phase 3 trial of REL-1017 as an adjunctive treatment for Major Depressive Disorder has been t…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder [NA]
VA-sponsored clinical trial comparing individual therapies for veterans with major depressive disorder, posttraumatic stress disorder, and p…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) [Phase 3]
A Phase 3 clinical trial evaluating REL-1017 as an adjunctive treatment for Major Depressive Disorder has been terminated, according to the …
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder [NA]
A completed clinical trial assessed a digital intervention to treat anxiety and depression in people undergoing treatment for opioid use dis…
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Evaluation of Teen Connection Project for Trans and Gender Minority Youth [NA]
Completed clinical trial by the University of Michigan evaluating the Teen Connection Project for transgender and gender minority youth, foc…
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Electronic Media and Its Application in Psychotherapy [NA]
A clinical trial conducted by McLean Hospital evaluating electronic media in psychotherapy for anxiety disorders and depression has complete…
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder [Phase 1]
Phase 1 clinical trial update for psilocybin in major depressive disorder; the Yale University study is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: Sleep TMS for Depression [NA]
A trial evaluating sleep-targeted transcranial magnetic stimulation for major depressive disorder has completed. No efficacy results are pro…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: Neuromodulation for Comorbid Hoarding Disorder and Depression [NA]
Completed clinical trial evaluating neuromodulation as a treatment for hoarding disorder with comorbid depression.
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder [Phase 3]
Open-label Phase 3 trial evaluating lumateperone as adjunctive therapy for Major depressive disorder; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Testing the Feasibility of the Individualized Positive Psychosocial Intervention (IPPI) [NA]
The clinical trial update reports on the feasibility of the Individualized Positive Psychosocial Intervention (IPPI) for individuals with de…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Designing a Mobile App to Support Academic Success for Student Veterans [NA]
This completed study evaluated a mobile app to support academic success for student veterans. It reported results related to mental health c…
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2 [NA]
This document reports the completion of Study 2 evaluating hyperthermia as an adjunct treatment for major depressive disorder. Results have …
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Message-Based Psychotherapy and Digital Treatment Sequences for Depression [NA]
A Talkspace-sponsored study evaluating message-based psychotherapy and digital treatment sequences for depressive disorder has completed, an…
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 trial evaluating the efficacy and safety of NBI-1070770 in adults with Major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: iCBT With TMS in Patients With MDD [NA]
This clinical trial update notes that a study of internet-based cognitive behavioral therapy combined with transcranial magnetic stimulation…
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration [NA]
This ClinicalTrials.gov entry reports the completed results of the RISE program, a resilience intervention for men leaving incarceration, ev…
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers [NA]
A completed clinical trial (MAC) evaluated an intervention to reduce anxiety in older adults with cancer and their caregivers. The study was…
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CLINICAL_TRIALS trial_result · 2025-10-27Clinical Trial Update: Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Rates of Depression [NA]
The VA-sponsored trial assessed whether adding a tailored cognitive behavioral therapy mobile skills app can influence depression outcomes; …
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CLINICAL_TRIALS trial_result · 2025-10-24Clinical Trial Update: Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia [NA]
Completed clinical trial from Oregon Health and Science University evaluating neighborhood-based physical and social activity for older Blac…
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder [Phase 3]
A Phase 3 randomized trial compares Azetukalner to placebo in Major Depressive Disorder, with recruitment currently ongoing.
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CLINICAL_TRIALS trial_result · 2025-10-21Clinical Trial Update: Open-Label of SPN-820 in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 open-label study of SPN-820 in adults with major depressive disorder has completed and posted results.