Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine [NA]
This clinical trial update describes a study integrating digital phenotyping and AI-driven cognitive-behavioral therapy to advance precision…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Transcranial Direct Current Stimulation for Depression [NA]
A clinical trial evaluating transcranial direct current stimulation as a treatment for depression is listed as not yet recruiting.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay [NA]
Clinical trial NCT06294119 is currently recruiting to evaluate a multivariate approach for numerical assessment of cortical-autonomic-vascul…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality [NA]
This clinical trial update reports on a study examining brain changes during social reward-based psychotherapy for mid- and late-life suicid…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Neurobiology of Suicide [Phase 2]
A Phase 2 clinical trial update on the neurobiology of suicide, sponsored by NIMH, currently recruiting participants including healthy volun…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder [NA]
A clinical trial evaluating electrophysiological markers of antidepressants in Major Depressive Disorder is listed, with recruitment not yet…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression [Phase 1, Phase 2]
An update on a Phase 1/2 clinical trial of psilocybin derived from Psilocybe cubensis mushrooms, with or without fluoxetine, for refractory …
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder
This ClinicalTrials.gov update describes a recruiting study investigating gender differences in depression severity, gender-sensitive sympto…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Positive Affect Treatment for Spanish-Speaking Individuals [NA]
This clinical trial update describes a study testing Positive Affect Treatment for adults with anhedonia and depression, currently active bu…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Validation of Accexible as a Tool for Screening and Monitoring Depression.
The document summarizes a completed clinical trial validating Accexible as a tool for screening and monitoring Major Depressive Disorder.
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: SUBDIMA: Subclinical Depression in Acute Myocardial Infarction (SUBDIMA25) [NA]
Clinical trial SUBDIMA25 is investigating subclinical depression in patients with acute myocardial infarction; the study is currently recrui…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder [NA]
A clinical trial evaluating intradermal acupuncture as an adjunct to help taper SSRI doses in adults with Major Depressive Disorder.
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Neutralizing Interleukin (IL)-6 [Phase 2]
A Phase 2 clinical trial evaluating a neutralizing interleukin-6 agent for major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Physical Activity-based Intervention in Depressed Patients: Clinical, Neurophysiological, Epigenetic and Metabolic Correlates [NA]
This clinical trial investigates a physical activity-based intervention for adults with Major Depressive Disorder, examining clinical outcom…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Personalized Mobile Cognitive Behavioral Therapy Application [NA]
A personalized mobile cognitive behavioral therapy application is being evaluated in a recruiting clinical trial for anxiety disorders, depr…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study) [Phase 2]
A Phase 2 trial (BUOY-1) is evaluating the efficacy and safety of SPT-300 (GlyphAllo) for major depressive disorder with or without anxious …
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects [Phase 1]
This Phase 1 trial at the Medical University of Vienna is exploring how the psychedelic experience from psilocybin relates to its anti-anhed…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Nutritional Intervention for College Students With Depression [NA]
A clinical trial is currently recruiting college students with major depressive disorder to assess a nutritional intervention for depressive…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease [Phase 2]
Ongoing Phase 2 clinical trial evaluating probiotic treatment for depression and associated mood disorders in Parkinson disease; the study i…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 double-blind, placebo-controlled trial in adults with major depressive disorder is currently recruiting, sponsored by Supernus Pha…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts [Phase 4]
A Phase 4 clinical trial is investigating whether the kappa opioid receptor mediates ketamine's ability to reduce suicidal thoughts in indiv…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Social Media Concerns Related to Emotional Experiences in Naturalistic Settings (SCREENS)
The update describes a naturalistic clinical study at University of Texas Southwestern Medical Center examining how social media experiences…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Technology dRiven Enhancement to Engage & Connect [NA]
A clinical trial update from Weill Medical College of Cornell University indicates a technology-driven enhancement study for depression that…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study of Brenipatide in Adult Participants With Major Depressive Disorder [Phase 3]
A Phase 3 trial evaluating Brenipatide for major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder [Phase 2]
Phase 2 clinical trial update for oral Icalcaprant in adults with Major Depressive Disorder, assessing change in disease activity and advers…