Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Identifying and Treating Depression in the Orthopaedic Trauma Population [Phase 4]
Phase 4 clinical trial investigating identification and treatment of depression in patients with orthopaedic trauma; currently recruiting. S…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) [Phase 3]
A Phase 3 randomized study investigating azetukalner versus placebo for major depressive disorder is currently recruiting (X-NOVA3).
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Treating Immuno-metabolic Depression With Anti-inflammatory Drugs [Phase 3]
This clinical trial update describes a Phase 3 study evaluating anti-inflammatory drugs for immuno-metabolic depression, with the trial curr…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study to Assess the Safety and Effectiveness of NMRA-335140-501 [Phase 3]
This clinical trial update describes a Phase 3 study (NMRA-335140-501) evaluating safety and effectiveness in Major Depressive Disorder, whi…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder [Phase 3]
This document provides a status update for a Phase 3 trial evaluating the oral NMRA-335140 in major depressive disorder, noting the study is…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Deaf CBT-TS to Reduce Suicide Risk [NA]
Update on a clinical trial evaluating Deaf CBT-TS for reducing suicide risk. The study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
NIMH-sponsored clinical trial evaluating mood and anxiety disorders, including bipolar disorder and major depressive disorder, is currently …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder [Phase 3]
Phase 3 clinical trial update evaluating oral NMRA-335140 versus placebo in adults with Major Depressive Disorder; study status shows as act…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder
A recruiting study comparing stress, inflammation, and neuroimaging features in individuals with major depressive disorder versus premenstru…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Identifying and Measuring Depression in Older Cancer Patients
This clinical trial studies methods to identify and measure depressive symptoms in older adults with cancer. The study is currently active b…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use [NA]
A clinical trial evaluating remotely delivered programs to address COVID-19-related stress, depression, and substance use has completed.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Painhunting Therapy for Interpersonal Loss-Related Depression [NA]
A clinical trial evaluating Painhunting Therapy for depression related to interpersonal loss; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis [NA]
Pilot study evaluating sensor-informed smartphone-based mental health interventions to improve mood in individuals with early psychosis; not…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Brief Trial of ACT-i for Adults With Chronic Insomnia [NA]
This clinical trial update indicates that ACT-i for adults with chronic insomnia is currently recruiting. The study also lists co-occurring …
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Solomiya App - CBT-based Self-help Intervention [NA]
This update describes the Solomiya CBT-based self-help app for the prevention of sleep disorders, PTSD, and depression, which is not yet rec…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Mindfulness Engaged Neurostimulation for Depression (MEND II) [Phase 2]
Phase 2 clinical trial evaluating Mindfulness Engaged Neurostimulation for Depression is not yet recruiting, studying treatment options for …
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Low Voltage Electrical Stimulation for Depression in Parkinson's Patients [NA]
This clinical trial update reports that a study investigating low voltage electrical stimulation to treat depressive symptoms in Parkinson's…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Behavioral and Neuronal Correlates of Human Mood States [NA]
A Stanford University clinical trial investigating behavioral and neuronal correlates of mood states in adults with Major Depressive Disorde…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This clinical trial update notes that enrollment is ongoing for an intra-ovarian Muse cell injection (Muse cell therapy) aimed at alleviatin…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS [NA]
A University of Minnesota-led study is recruiting to evaluate vagal excitation and its anatomical connections in epilepsy and major depressi…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Implementing Depression and Adherence Treatment [NA]
A University of Miami-sponsored clinical trial aims to implement treatments for depression and medication adherence in people living with HI…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Psilocybin-Assisted Therapy in Treatment-Resistant Depression [Phase 3]
Phase 3 trial evaluating psilocybin-assisted therapy for treatment-resistant depression is currently recruiting at the University of North C…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Shortened LSD Intervention for Major Depressive Disorder [Phase 1]
A Phase 1 clinical trial update describes a shortened LSD intervention for major depressive disorder. The study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: CARED : A Novel Rapid Treatment Paradigm for Depression [NA]
This clinical trial update outlines CARED, a novel rapid treatment paradigm for major depressive disorder, with the study listed as not yet …
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Trial [NA]
This document describes a protocol for an adaptive, internet-delivered, transdiagnostic intervention for emotional disorders that personaliz…