Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-04-23Clinical Trial Update: Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation [NA]
Clinical trial update examining pharmacological versus expectation effects in antidepressant discontinuation, sponsored by Universitätsklini…
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CLINICAL_TRIALS research · 2025-04-23Clinical Trial Update: Effects of an ACT-based Psychological Treatment in Patients With Chronic Kidney Disease [NA]
This entry describes a recruiting clinical trial evaluating Acceptance and Commitment Therapy-based psychological treatment for patients wit…
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Maintenance rTMS for Depression (Maitr-De) [NA]
Clinical trial update for maintenance rTMS in depression shows a recruiting study for major depressive disorder and treatment-resistant depr…
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Evaluating the Feasibility of a School-based Stepped Care Program for Internalizing Symptoms in Adolescents in Pakistan [NA]
A feasibility study evaluating a school-based stepped care program to address internalizing symptoms (depression and anxiety) among adolesce…
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CLINICAL_TRIALS research · 2025-04-21Clinical Trial Update: Brain Connectivity in Depression [NA]
This clinical trial update indicates that Brigham and Women's Hospital is recruiting participants for a study on brain connectivity in depre…
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CLINICAL_TRIALS research · 2025-04-20Clinical Trial Update: Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine [EARLY_Phase 1]
Emory University is conducting an early-phase 1 trial to explore whether glutamatergic adaptation to stress underpins anhedonia and treatmen…
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CLINICAL_TRIALS research · 2025-04-20Clinical Trial Update: The Mindfulness-Based Psycho-Educational Program Focused on Emotion Regulation Strategies [NA]
Clinical trial update for a mindfulness-based psycho-educational program focused on emotion regulation; the study is active but not recruiti…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: Effect of Tao Calligraphy Meditation and Energized Water on Depression [NA]
A clinical trial is evaluating Tao Calligraphy Meditation and Energized Water for unipolar depression, and is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: From Fear to Purpose ACT Protocol. Implications of Death Anxiety in Depression and Anxiety Symptoms. [NA]
This clinical trial protocol from Babes-Bolyai University investigates the role of death anxiety in depression and anxiety symptoms and prop…
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: Pramipexole to Enhance Social Connections [Phase 2]
A Phase 2 trial is evaluating pramipexole to enhance social connections in individuals with anxiety disorders and depression; the study is c…
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Effect of ChatGPT-Based Digital Counseling on Anxiety and Depression in Cancer: A Randomized Trial [NA]
A completed randomized trial evaluated the effect of ChatGPT-based digital counseling on anxiety and depression in cancer patients.
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: The Danish Neuropsychological Study of the Adverse Effects of ECT
Clinical trial update from the University of Copenhagen examining adverse effects of electroconvulsive therapy in depressive disorders.
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder [NA]
This clinical trial update indicates recruitment for an individualized non-invasive brain stimulation approach using transcranial alternatin…
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CLINICAL_TRIALS research · 2025-04-15Clinical Trial Update: Metacognitive Therapy for Depression and Generalized Anxiety Disorder in Primary Care, Blended Version of Mediated Treatment [NA]
Update on a primary care trial of metacognitive therapy for depression and generalized anxiety disorder, using a blended mediated-treatment …
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: A Neuroimaging Study of Open-label Placebo in Depressed Adolescents [NA]
This entry reports a neuroimaging study of open-label placebo in depressed adolescents, sponsored by the University of California, San Franc…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
An ongoing Mayo Clinic study recruiting participants to identify cerebral hemodynamic patterns in mood disorders and mild cognitive impairme…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Investigating Dynamic Interactions in Distributed Cognitive Control Networks
Clinical trial update on an ongoing study at the University of Alabama at Birmingham examining dynamic interactions in distributed cognitive…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Evaluation of Primary Care Behavioral Health (PCBH) With the Addition of Self-help CBT - A Randomized Multicenter Trial [NA]
A multicenter randomized trial evaluating primary care behavioral health with added self-help CBT is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
A clinical trial update shows recruitment for a study examining how benzodiazepines affect cognitive function using fNIRs and PET/MRI at The…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Imaging SV2A in Mood Disorders [NA]
This clinical trial update indicates ongoing recruitment for a study using SV2A imaging to investigate mood disorders, specifically major de…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Understanding and Treating Suicidal Ideation With Ketamine [Phase 2, Phase 3]
A clinical trial update indicates ketamine is being studied in Phase 2 and Phase 3 trials for suicidal ideation and major depressive disorde…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity
A clinical trial investigating how gut microbiome interactions contribute to anxiety, depression, and PTSD symptoms in individuals with earl…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: Is Less More? Dosing and Sequencing Effect [NA]
An update on a University of Aarhus trial exploring how dosing and sequencing affect outcomes for Depression and Anxiety; the study is not y…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: Behavioral Study to Predict the Efficacy of a Self-Help Tool [NA]
A behavioral study at Princeton is ongoing to predict the efficacy of a self-help tool for depressive symptoms. The trial is currently activ…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: An Internet-based Self-help Intervention to Improve Common Mental Health Problems Among Medical Professionals [NA]
This clinical trial is actively recruiting to test an internet-based self-help intervention for depression and anxiety in medical profession…