Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition [NA]
This clinical trial evaluates accelerated transcranial magnetic stimulation for depression with comorbid post-COVID-19 condition, focusing o…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Transdiagnostic, Indicated Preventive Intervention for Adolescents At High Risk of Emotional Problems W/Add-On Modules [NA]
A clinical trial update announcing a transdiagnostic preventive intervention for adolescents at high risk of emotional problems, with add-on…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Targeting Specific Brain Networks to Treat Specific Symptoms in Depression [NA]
A Massachusetts General Hospital study is actively recruiting to test whether targeting specific brain networks can alleviate particular sym…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [Phase 3]
A Phase 3 clinical trial is examining whether a six-week intensified pharmacological treatment improves outcomes in adults with major depres…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial [Phase 2]
Phase 2 proof-of-concept trial testing orexin antagonism for suicide risk in major depressive disorder; currently recruiting.
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Prediction of Antidepressant Effects of Electroconvulsive Therapy
A clinical trial is investigating whether electroconvulsive therapy can predict antidepressant effects in patients with major depressive dis…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients [NA]
A clinical trial investigating invasive decoding and stimulation to modify reward processing in patients with Major Depressive Disorder, cur…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Apimostinel + Automated Neurocognitive Training for Depression [Phase 2]
Phase 2 clinical trial update for depression evaluating Apimostinel in combination with Automated Neurocognitive Training; the study is curr…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Acupuncture for Anxiety/Depression in Patients With Breast Cancer [NA]
A clinical trial evaluating acupuncture for anxiety and depression in patients with breast cancer is currently not recruiting.
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy [NA]
The study 'M-O-M-S on the Bayou' is currently recruiting to implement an intervention for mental health in pregnancy, focusing on anxiety an…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Schema Therapy for Patients With Chronic Treatment Resistant Depression [NA]
A clinical trial is evaluating schema therapy for patients with chronic treatment-resistant depression, and the study is currently recruitin…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: In-patient SCC TMS [NA]
An in-patient transcranial magnetic stimulation trial (SCC TMS) for Major Depressive Disorder is currently recruiting at UCLA.
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Effect of Probiotics "Psychobiotics" on Depression and Metabolic Syndrome in Saudi Arabia [Phase 2, Phase 3]
Phase 2/Phase 3 clinical trial in Saudi Arabia evaluating the effects of probiotic psychobiotics on depression, anxiety disorders, and metab…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Internet-Based Cognitive Behavioral Therapy With Treatment as Usual for Generalized Anxiety Disorder and Major Depressive Disorder in Taiwan (ICBT-TW) [NA]
A clinical trial in Taiwan evaluating internet-based cognitive behavioral therapy in addition to usual care for generalized anxiety disorder…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Evaluation of the PACE/PACENET BHL Clinical Program
Clinical trial update on the PACE/PACENET BHL program indicates ongoing recruitment for studies addressing depression, anxiety disorders, an…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder [NA]
A completed clinical trial evaluating Extended Reality Behavioral Activation as an intervention for Major Depressive Disorder.
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas [NA]
This ClinicalTrials.gov entry describes an ongoing study in Taiwan evaluating mindfulness and brain stimulation interventions for late-life …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder [NA]
An ongoing UCLA-sponsored clinical trial is evaluating resonant frequency repetitive transcranial magnetic stimulation as a novel approach t…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Efficacy and Safety of Task-specific, Biomarker-driven, HD-ctACS inTRD. [NA]
Clinical trial update on the efficacy and safety of task-specific, biomarker-driven, HD-ctACS in treatment-resistant depression, sponsored b…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: SUpport From PEeRs to Expand Access Study - Community [NA]
This clinical trial update indicates the University of California, Berkeley–sponsored 'Support From Peers to Expand Access' Community study …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Prevention of ANxiety and Depression Over Risk Assessment [NA]
A clinical trial update describing a preventive study for anxiety and depression based on risk assessment, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD) [EARLY_Phase 1]
An early Phase 1 trial update evaluating intravenous citalopram hydrochloride during transcranial magnetic stimulation in major depressive d…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study [NA]
This clinical trial update describes a randomized, double-blind pilot study evaluating transcranial alternating current stimulation (tACS) f…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Motivational Multicomponent Lifestyle Interventions as a Supportive Treatment for Depression in Primary Health Care [NA]
This ClinicalTrials.gov update reports that a study evaluating motivational multicomponent lifestyle interventions as a supportive treatment…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Feasibility and Acceptability of Laughter Yoga in Children With Autism Spectrum Disorder and Their Parents [NA]
This clinical trial entry describes a feasibility and acceptability study of laughter yoga for children with autism spectrum disorder and th…