Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression [NA]
A clinical trial comparing fMRI-guided intermittent theta-burst stimulation (iTBS) versus standard iTBS for depression, currently recruiting…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: fMRI Neurofeedback With Matter Neuroscience App [NA]
Stanford University is conducting a clinical trial of fMRI neurofeedback using the Matter Neuroscience app to treat major depressive disorde…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression [NA]
A clinical trial update announces the REACH study for depression, sponsored by Dartmouth-Hitchcock Medical Center, currently not yet recruit…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder [NA]
A clinical trial update indicates a study evaluating closed-loop transcranial alternating current stimulation for major depressive disorder …
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Change in Social Media Use and Well-being Among College Students Receiving a Two-week Exercise or Mindfulness Intervention [NA]
A Johns Hopkins trial is recruiting college students to evaluate how a two-week exercise or mindfulness program affects social media use and…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: An Empirical Study on the Mechanisms of Biopsychosocial Functional Improvement in Patients With Major Depressive Disorder Through Nature-Based Tourism Activities [NA]
This clinical trial update describes an ongoing empirical study examining how biopsychosocial functional improvements in patients with Major…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients
An ongoing clinical trial sponsored by the Lithuanian University of Health Sciences is evaluating depressive symptoms, cognitive impairment,…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression [Phase 4]
This Phase 4 clinical trial compares right-sided 1-Hz repetitive transcranial magnetic stimulation with left-sided intermittent theta burst …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Sequential Multiple Assignment Randomized Trial for Bipolar Depression [Phase 4]
This ClinicalTrials.gov Phase 4 study uses a sequential multiple assignment randomized trial design to evaluate treatments for bipolar depre…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Effectiveness of Digital Cognitive Behavioral Therapy for the Treatment of Depression [NA]
This entry notes an ongoing clinical trial evaluating digital cognitive behavioral therapy for depression, with status listed as active but …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Implementation Strategies for Task-Shifting Depression Care Depression Care in Vietnam [NA]
Completed clinical trial updating on implementation strategies for task-shifting depression care in Vietnam. The study focuses on care deliv…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan [Phase 4]
Ongoing Phase 4 trial comparing electroconvulsive therapy (ECT) and ketamine for acute suicidal depression, evaluating comparative effective…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Predictors of rTMS and Group Therapy Efficacy in Adolescent Depression
This completed clinical trial investigates predictors of response to rTMS and group therapy in adolescents with major depressive disorder.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Investigation on Risk Factors for Suicide Among Chinese Patients With Mood Disorders
A Shanghai Mental Health Center study is investigating risk factors for suicide among Chinese patients with mood disorders (bipolar disorder…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Effectiveness of Digital Cognitive Behavioral Therapy for the Treatment of Depression: a Real-world Study [NA]
A real-world study is evaluating the effectiveness of digital cognitive behavioral therapy for depression. The trial is currently recruiting…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Implementation of Collaborative Care for Depression in VA HIV Clinics [NA]
Trial update on implementing collaborative care for depression in VA HIV clinics; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Video Intervention to Reduce Depression-related Stigma Among Adolescents [NA]
A clinical trial evaluating a video intervention designed to reduce depression-related stigma among adolescents; the study is currently not …
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Treatment of SSD With tcVNS and taVNS [NA]
A clinical trial is evaluating transcutaneous vagus nerve stimulation (tcVNS) and taVNS for somatic symptom disorder with anxiety and depres…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Validate the Temporal Stability and Responsiveness of AI-COA® for Depression and Anxiety
Clinical trial update to validate the temporal stability and responsiveness of AI-COA for depression and anxiety; not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Kernel is conducting a clinical study to predict response to depression interventions using clinical data and TD-fNIRS measurements. The stu…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT [NA]
This clinical trial is currently recruiting to test an integrated care model for older adults (65 years and older) with major depressive dis…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis [NA]
This clinical trial update describes a study comparing inflammatory markers in patients with chronic periodontitis who have depression versu…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Early Life Stress and Depression: Molecular and Functional Imaging
A study sponsored by McLean Hospital on early life stress and depression using molecular and functional imaging, currently recruiting partic…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants [NA]
A Karolinska Institutet–sponsored trial is recruiting to evaluate a culturally adapted internet-based cognitive-behavioral therapy for Farsi…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression [Phase 2]
This Phase 2 cross-over trial investigates whether dalfampridine affects working memory in people with mild to moderate depression and is cu…