Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work [NA]
A University of Roehampton trial is evaluating AI avatar–led mental health interventions to help employees with depression remain at work, a…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study [NA]
ClinicalTrials.gov update describes a study of self-help Cognitive Processing Therapy combined with the Women Veterans Network for posttraum…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression [NA]
Clinical trial evaluating virtual reality-based mindfulness as an adjunct to treatment as usual for treatment-resistant depression. The stud…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Accelerated TMS for Depression and OCD [NA]
Clinical trial evaluating accelerated transcranial magnetic stimulation for depression and obsessive-compulsive disorder is currently recrui…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction [NA]
The Sleep and Light Intervention (SALI) trial at the University of California, San Diego is evaluating a sleep and light therapy for menopau…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Health Questionnaire Study [NA]
University of California, Irvine is conducting a health questionnaire study related to depression and anxiety that is currently active but n…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Biomarker-guided rTMS for Treatment Resistant Depression [Phase 3]
Phase 3 clinical trial investigating biomarker-guided repetitive transcranial magnetic stimulation for treatment-resistant depression is cur…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: The Advance Project - Advancing Sleep Timing to Improve Depression [NA]
This update describes a clinical trial exploring whether advancing sleep timing can improve depressive symptoms, sponsored by University Hos…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
This clinical trial update describes a study examining how lithium impacts the brain's functional and structural connectome in treating bipo…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial [NA]
This clinical trial update describes a study comparing imaging-targeted versus scalp-targeted accelerated transcranial magnetic stimulation …
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic [NA]
This clinical trial update describes The Exhale Study, an ongoing investigation into treating maternal depression in an urban pediatric asth…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Parent-Adolescent Relationships, Emotional Regulation, and HRV in Adolescents With Depression
The study investigates how parent-adolescent relationships and emotional regulation relate to heart rate variability in adolescents with dep…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Personalized Brain Stimulation to Treat Chronic Concussive Symptoms [Phase 2]
Phase 2 clinical trial investigating personalized brain stimulation to treat chronic concussion symptoms is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression [Phase 1]
A Phase 1 clinical trial is exploring the mechanism by which ketamine may exert antidepressant effects in treatment-resistant major depressi…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Lonely in Depression
A clinical trial from Friedrich-Alexander-Universität Erlangen-Nürnberg is currently recruiting to study loneliness in individuals with depr…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) [Phase 4]
A Phase 4 clinical trial from Mayo Clinic is evaluating whether RNA editing can serve as a biomarker to predict antidepressant response in a…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder
Karolinska Institutet is conducting a trial to identify psychobiological markers to improve diagnosis and predict affective episodes in bipo…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression [NA]
Clinical trial update on deep brain stimulation therapy for treatment-resistant depression, with status active but not recruiting.
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
This clinical trial update describes a retrospective observational study evaluating blood-based biomarkers for diagnosing and monitoring sev…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: IWLS for Major Depressive Disorder: An Open-Label Study of Safety, Tolerability, and Efficacy [NA]
Open-label clinical trial updating the safety, tolerability, and efficacy of IWLS for major depressive disorder; status is ACTIVE_NOT_RECRUI…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation [NA]
This clinical trial update indicates that the Johns Hopkins University study exploring transcranial direct current stimulation to understand…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: MISAPSY: Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults [NA]
A new, not-yet-recruiting clinical trial in France investigates how childhood maltreatment, food insecurity, and psychological distress infl…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Depression Among Medical Students at Sohag University
A clinical trial sponsored by Sohag University investigating major depressive disorder is not yet recruiting.
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: The BEAR Program for Women With Trauma Who Have Suicidal Thoughts [NA]
Stanford is conducting the BEAR Program, a clinical trial recruiting women with trauma who have suicidal thoughts to study interventions for…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Individualized (fMRI-guided) TMS Treatment for Depression [NA]
University of Pennsylvania is conducting a trial testing individualized fMRI-guided transcranial magnetic stimulation for depression, includ…