Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression [NA]
A brain stimulation study in depression examines the causal role of the rostromedial prefrontal cortex in positive savoring. The trial is cu…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression [EARLY_Phase 1]
This is an early-phase randomized pilot study evaluating repetitive transcranial magnetic stimulation (rTMS) for knee osteoarthritis pain wi…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Digital Interventions for Relapse Prevention in Adolescence [NA]
University of Oslo is conducting a clinical trial of digital interventions to prevent relapse in adolescents with major depressive disorder …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Behavioral Health Collaborative Care Model in an ICU Recovery Clinic [NA]
A clinical trial is evaluating a Behavioral Health Collaborative Care Model in an ICU recovery clinic, with recruitment currently ongoing.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans [NA]
A clinical trial is recruiting to study neural mechanisms of repetitive brain stimulation using invasive and noninvasive electrophysiology i…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot [NA]
The trial is recruiting at the Medical University of South Carolina for a Behavioral Health Collaborative Care Model in a post-ICU clinic fa…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
A National Institute of Mental Health study is conducting a prospective natural history study of motor activity and mood states in bipolar d…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Concurrent TMS-fMRI [NA]
A clinical trial entry notes ongoing recruitment for concurrent transcranial magnetic stimulation (TMS) with fMRI in healthy controls and in…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2 [NA]
A clinical trial update for NCT05267340 describes an MRI connectome study of meditation training effects on brain networks in healthy and de…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Acupuncture and Escitalopram for Treating Major Depression Clinical Study [NA]
This clinical trial update describes a study evaluating the combination of acupuncture and escitalopram for major depressive disorder, which…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Perinatal Research on Improving Sleep and Mental Health [NA]
Clinical trial update from UCSF describing perinatal research to improve sleep and mental health, focusing on insomnia and depression; the s…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) [Phase 3]
This document describes a Phase 3 long-term extension trial (EXTEND) to evaluate the safety and efficacy of CYB003 in major depressive disor…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth [Phase 3]
A Phase 3 clinical trial is evaluating prefrontal glutamatergic modulation with N-acetylcysteine (NAC) and mindfulness-based cognitive thera…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study of Vortioxetine in Japanese Pediatric Patients With Major Depressive Disorder [Phase 3]
A Phase 3 clinical trial evaluating vortioxetine in Japanese pediatric patients with major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Open-Label Psilocybin Study in Transdiagnostic Population [Phase 1]
Open-label Phase 1 trial of psilocybin in a transdiagnostic population. The study targets major depressive disorder, anxiety disorders, post…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression [NA]
This clinical trial update reports a Florida State University-sponsored study investigating the causal role of delta-beta coupling in goal-d…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety [NA]
An update on a clinical trial evaluating low-intensity focused ultrasound as a treatment for depression. The study is sponsored by Ocean Sta…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk [NA]
An ongoing study is evaluating accelerated intermittent theta burst stimulation as a treatment for adolescent and young adult depression wit…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Effect of Virtual Reality on Depression in Adolescent Females [NA]
A Cairo University–led clinical trial is exploring whether virtual reality can reduce depressive symptoms in adolescent females. The study s…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Veterans and First Responders
A ClinicalTrials.gov entry describes a study using integrated care and wearable technology to evaluate outcomes of the Shields & Stripes pro…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: LHC-CIDI-5 in Hong Kong
A clinical trial update indicates that LHC-CIDI-5 is currently recruiting in Hong Kong for multiple psychiatric conditions, including major …
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE) [NA]
A clinical trial is evaluating light therapy for unipolar and bipolar major depressive episodes, sponsored by Assistance Publique - Hôpitaux…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: NUTRIBRAIN: Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice (POWER) [NA]
This clinical trial entry describes the NUTRIBRAIN POWER study, which investigates lifestyle interventions to prevent cognitive deficits in …
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Imaging Depression in Parkinson's Disease [Phase 2]
A Phase 2 clinical trial update from Yale University on imaging depression in Parkinson's disease, currently recruiting.
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
A clinical trial is validating the online Creyos cognitive assessment platform in older adults with Mild Cognitive Impairment or remitted Ma…