Major Depressive Disorder Treatment-resistant

• CLINICAL_TRIALS research · 2026-01-26
  Clinical Trial Update: A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.

  An update announcing a study to assess the effectiveness and efficiency of vagus nerve stimulation therapy for patients with treatment-resis…

• CLINICAL_TRIALS research · 2025-08-06
  Clinical Trial Update: Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression [NA]

  This entry notes an ongoing clinical trial at Sunnybrook Health Sciences Centre evaluating magnetic resonance-guided focused ultrasound bila…

• CLINICAL_TRIALS research · 2025-07-04
  Clinical Trial Update: Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS) [Phase 2]

  A Phase 2 triple-blind randomized trial in Brazil will evaluate tocilizumab as an adjunct to standard treatment for treatment-resistant majo…

• CLINICAL_TRIALS trial_result · 2025-04-04
  Clinical Trial Update: Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD) [Phase 2]

  Phase 2 trial evaluating MIJ821 for treatment-resistant depression has completed with results posted, assessing efficacy, safety, tolerabili…

• CLINICAL_TRIALS research · 2025-02-06
  Clinical Trial Update: Theta Burst Stimulation With an 8-Coil Versus H1-Coil for Resistant Depression [NA]

  Clinical trial comparing theta burst stimulation using an 8-coil versus the H1-coil for treatment-resistant depression; status is not yet re…

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• CLINICAL_TRIALS trial_result · 2014-04-01
  Clinical Trial Update: A Study in Relapse Prevention of Treatment-Resistant Depression [Phase 3]

  A Phase 3 relapse-prevention trial for treatment-resistant depression completed, with results posted in 2014.

• CLINICAL_TRIALS trial_result · 2011-11-22
  Clinical Trial Update: Sequential Left Prefrontal Repetitive Transcranial Magnetic Stimulation, With High Frequency, for Treatment-Resistant Depression [NA]

  Clinical trial update on sequential left prefrontal high-frequency repetitive transcranial magnetic stimulation for treatment-resistant depr…

• CLINICAL_TRIALS research · 2011-09-15
  Clinical Trial Update: Deep Brain Stimulation in Treatment Resistant Depression [NA]

  Clinical trial update on deep brain stimulation for treatment-resistant depression (NCT01435148) sponsored by North Bristol NHS Trust; the c…