Lymphatic Malformation
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Lymphatic Anomalies Registry for the Assessment of Outcome Data
The ClinicalTrials.gov study NCT02399527 at Boston Children's Hospital is a recruiting registry to collect outcome data on lymphatic anomali…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. [Phase 2, Phase 3]
A Phase 2/3 trial evaluates alpelisib for lymphatic malformations associated with PIK3CA mutations in pediatric and adult patients; recruitm…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Weekly Sirolimus Therapy [Phase 2]
This entry describes a Phase 2 clinical trial evaluating weekly sirolimus therapy for venous malformation and lymphatic malformation that is…
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CLINICAL_TRIALS trial_result · 2026-02-23Clinical Trial Update: National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)
The PROS clinical trial (NCT05563831) has completed, providing an update on patients with PIK3CA-related overgrowth spectrum and related con…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations [Phase 2]
Phase 2 clinical trial update evaluating targeted therapies for slow-flow and fast-flow vascular malformations; the study is currently recru…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: A Prospective Study on the Treatment of cLM Based on ICG Imaging [NA]
A prospective study evaluating treatment of congenital lymphatic malformation guided by indocyanine green imaging, currently recruiting at N…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: Topical Sirolimus in Cutaneous Lymphatic Malformations [Phase 2]
A Phase 2 trial evaluating topical sirolimus for cutaneous lymphatic malformations has been completed.
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation [Phase 2]
Phase 2 clinical trial update for RLY-2608, a mutant-selective PI3Kα inhibitor, in adults and children with PIK3CA-related overgrowth spectr…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations [Phase 2]
This clinical trial compares injection sclerotherapy using Bleomycin versus Doxycycline for lymphatic malformations in Phase 2 and is curren…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations [Phase 2]
Phase 2 clinical trial evaluating sirolimus (rapamycin) for cervico-facial lymphatic malformations in pediatric patients; currently recruiti…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age [Phase 2]
Phase 2 study evaluating the safety and efficacy of Intracystic TARA-002 for treating lymphatic malformations in children aged 6 months to u…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Diagnostic Imaging of Vascular Malformations Using MSOT and ULM
A clinical trial update describes evaluating multispectral optoacoustic tomography (MSOT) and ultrafast localization microscopy (ULM) for di…
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Institution of an Italian Registry and Biobank for Biological Sample Collection [NA]
An Italian registry and biobank are being established to collect biological samples for lymphatic malformation and related lymphatic conditi…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: Indocyanine Green Lymphography in Management of Lingual Lymphatic Malformation [NA]
A clinical trial evaluating Indocyanine Green lymphography for managing lingual lymphatic malformation has completed.
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CLINICAL_TRIALS trial_result · 2024-12-31Clinical Trial Update: Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations [Phase 2, Phase 3]
Clinical trial evaluating multiple doses of sirolimus for cystic lymphatic malformations is currently recruiting for Phase 2 and Phase 3 stu…
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CLINICAL_TRIALS research · 2024-06-03Clinical Trial Update: Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients [Phase 2]
Phase 2 clinical trial update evaluating bleomycin as sclerotherapy for pediatric lymphatic malformations; the study is currently recruiting…
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CLINICAL_TRIALS trial_result · 2014-06-12Clinical Trial Update: A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations [Phase 1, Phase 2]
Results from a Phase 1/2 study evaluating sildenafil for the treatment of lymphatic malformations (lymphangioma) are reported; the trial con…
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CLINICAL_TRIALS trial_result · 2012-10-26Clinical Trial Update: Diagnosis of Hemangiomas and Vascular Malformations
This document reports a completed clinical trial focused on the diagnosis of hemangiomas and various vascular malformations.