Low-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. [Phase 2]
Phase 2 clinical trial evaluating trametinib in pediatric neuro-oncology patients with refractory tumors showing MAPK/ERK pathway activation…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma [NA]
Clinical trial evaluating hippocampal-avoidance using proton therapy in various low-grade gliomas; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma
This clinical trial update discusses using seizure control as a new metric to assess the efficacy of tumor treatment in patients with low-gr…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Patient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Compared
A clinical trial update describing a study in low-grade gliomas evaluating patient-reported outcomes with vorasidenib in combination with ra…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: FCI in Post-operative Low Grade Gliomas [NA]
A clinical trial evaluating FCI in patients with post-operative low-grade gliomas has completed.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery [NA]
A clinical trial is testing a new fluid to improve ultrasound image quality during brain tumor surgery and is currently recruiting. Sponsor:…
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CLINICAL_TRIALS other · 2026-04-14Clinical Trial Update: Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy [Phase 2]
This ClinicalTrials.gov entry describes a Phase 2 study investigating the biology of IDH-mutant gliomas by longitudinally tracking 2-hydroxy…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma [Phase 3]
A Phase 3 randomized trial comparing selumetinib to carboplatin and vincristine in patients with low-grade glioma is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma [Phase 3]
This clinical trial update describes a Phase 3 study comparing selumetinib alone to selumetinib plus vinblastine in patients with recurrent …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma [Phase 1, Phase 2]
Selumetinib is being studied in pediatric patients with recurrent or refractory low-grade glioma across Phase 1 and Phase 2 trials; the stud…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) [Phase 1]
A Phase 1 PNOC021 trial of trametinib and everolimus for pediatric and young adult patients with recurrent gliomas has been suspended.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma [Phase 3]
Phase 3 trial comparing selumetinib to carboplatin/vincristine in patients with neurofibromatosis type 1-associated low-grade glioma, with t…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations [Phase 2]
Phase 2 clinical trial update announcing the evaluation of FORE8394 in participants with cancers harboring BRAF alterations, including high-…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma [NA]
An ongoing clinical trial is evaluating the efficacy of Laser Interstitial Thermal Therapy in young patients with low-grade glioma, includin…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma [Phase 2]
DS-1001b is a Phase 2 study in IDH1-mutated, chemo- and radiotherapy-naive WHO Grade II glioma. The trial is currently active but not recrui…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: A Study of AB-218 in Patients With IDH1 Mutated Low Grade Glioma [EARLY_Phase 1]
This update reports the completion of an early-phase study of AB-218 in IDH1-mutated low-grade glioma, with the trial status now listed as C…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas [Phase 1]
A Phase 1 clinical trial evaluating the combination of BGB-290 with temozolomide in patients with IDH1/IDH2-mutant gliomas, including gliobl…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma [NA]
A clinical trial of Vorasidenib guided by AGX PET in recurrent and low-grade glioma is not yet recruiting, with Huashan Hospital listed as s…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas [Phase 2]
A Phase 2 clinical trial evaluating the combination of dabrafenib and trametinib for BRAF V600-mutant low-grade gliomas is currently recruit…
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms [Phase 2]
A Phase 2 clinical trial evaluating Fluoroethyltyrosine for the evaluation of intracranial neoplasms, including low-grade glioma and recurre…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2) [Phase 3]
This clinical trial update describes a Phase 3 study (LOGGIC/FIREFLY-2) comparing DAY101 to standard-of-care chemotherapy for pediatric low-…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours [Phase 1]
A Phase 1 clinical trial in Japan is evaluating the safety and dosing of Tovorafenib in children and young adults with brain tumors, specifi…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Mind-Body Intervention in Glioma Couples [NA]
Clinical trial update for a mind-body intervention targeting glioma patients and their partners. The study is currently active but not recru…
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EMA approval · 2026-02-27New medicine to treat paediatric low-grade glioma
EMA approved a new medicine, Ojemda, to treat paediatric low-grade glioma in children aged 6 months and older, including tumours with BRAF a…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Study of Avutometinib for People With Solid Tumor Cancers [Phase 1]
A Phase 1 study of Avutometinib for people with solid tumors, including CNS tumors and NF1-associated tumors, is currently recruiting.