Limbal Stem Cell Deficiency
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency [Phase 1]
A Phase 1 trial to evaluate the safety and efficacy of CSB-001 Ophthalmic Solution 0.1% for limbal stem cell deficiency is currently recruit…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: BRM421 Ophthalmic Solution in Patients With Limbal Stem Cell Deficiency
An update on the BRM421 ophthalmic solution being studied for Limbal Stem Cell Deficiency, including the current status of the clinical tria…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Stem Cell Therapy for Limbal Stem Cell Deficiency [Phase 1]
This clinical trial update notes a Phase 1 study of stem cell therapy for limbal stem cell deficiency conducted by the University of Califor…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Treatment of LSCD With DM [Phase 1]
A Phase 1 clinical trial evaluating DM for treatment of limbal stem cell deficiency in congenital aniridia conducted by the University of Mi…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation
A recruiting clinical trial is investigating genotype-phenotype correlations in genetic-origin limbal stem cell deficiency.
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on Glaucoma
This clinical trial update describes a study assessing the relationship between limbal function and tear proteomics in chronic ocular diseas…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency [NA]
This clinical trial update indicates that autologous cultured corneal epithelium (CECA) is being studied for the treatment of limbal stem ce…
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EMA approval · 2025-07-08EMA Authorised: Holoclar (ex vivo expanded autologous human corneal epithelial cells containing stem cells) — Holostem s.r.l.
The European Medicines Agency authorised Holoclar, an autologous stem cell-based therapy for repairing the corneal surface in patients with …
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)
This clinical trial update indicates that Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency is not yet rec…
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial [Phase 2]
This update reports the completion of a Phase II multicenter trial evaluating limbal epithelial stem cell transplantation for limbal stem ce…
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft [Phase 1, Phase 2]
Phase 1/2 trial evaluating the CALEC graft for limbal stem cell deficiency has completed enrollment and posted results.
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CLINICAL_TRIALS research · 2024-08-19Clinical Trial Update: Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium [NA]
This clinical trial update describes a protocol to transdifferentiate buccal mucosal epithelium into corneal epithelium as a treatment for l…
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CLINICAL_TRIALS research · 2024-05-14Clinical Trial Update: Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
This update outlines a clinical trial on validating human drug targets for repurposed drugs and novel therapies, focusing on ocular diseases…
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CLINICAL_TRIALS trial_result · 2022-10-07Clinical Trial Update: Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating allogeneic ABCB5-positive limbal stem cells for treatment of limbal stem cell deficiency.
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CLINICAL_TRIALS trial_result · 2022-04-01Clinical Trial Update: Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency [Phase 4]
Phase 4 trial update on autologous cultivated limbal stem cell transplantation for restoration of corneal epithelium in patients with limbal…
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CLINICAL_TRIALS trial_result · 2019-10-11Clinical Trial Update: Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency [Phase 1, Phase 2]
Phase 1/2 trial update on transplantation of autologous oral mucosal epithelial sheets for limbal stem-cell deficiency.
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CLINICAL_TRIALS trial_result · 2018-03-06Clinical Trial Update: ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation [NA]
The clinical trial evaluating ABCB5 as a prognostic marker in survival after cultivated limbal stem cell transplantation for limbal stem cel…
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CLINICAL_TRIALS trial_result · 2017-07-21Clinical Trial Update: Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency
The clinical trial investigating autologous oral mucosa transplantation for Limbal Stem Cell Deficiency has completed, with Klinikum Chemnit…
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CLINICAL_TRIALS research · 2017-01-10Clinical Trial Update: Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating transplantation of autologous oral mucosal epithelial stem cell sheets to treat limbal stem cell defic…
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CLINICAL_TRIALS research · 2016-04-20Clinical Trial Update: Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
This clinical trial update outlines a study evaluating autologous oral mucosal epithelial sheet transplantation for ocular surface diseases.…
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CLINICAL_TRIALS trial_result · 2016-01-07Clinical Trial Update: The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED) [Phase 1]
Phase 1 trial evaluating Amniotic Membrane Extract Eye Drop (AMEED) for unilateral Limbal Stem Cell Deficiency has completed.
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CLINICAL_TRIALS withdrawal · 2015-03-25Clinical Trial Update: Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency [Phase 3]
A Phase 3 multicenter trial evaluating CAOMECS transplantation for total limbal stem cell deficiency has been withdrawn.
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CLINICAL_TRIALS research · 2013-06-20Clinical Trial Update: Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency [Phase 1, Phase 2]
Clinical trial update on cultivated stem cell transplantation for treating Limbal Stem Cell Deficiency, covering Phase 1 and Phase 2 trials …
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CLINICAL_TRIALS trial_result · 2012-12-10Clinical Trial Update: Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo [Phase 2]
A Phase 2 clinical trial using ex vivo amplified progenitor cells from the sclerocorneal limbus to repair the ocular surface has completed f…
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CLINICAL_TRIALS research · 2012-03-06Clinical Trial Update: Using Amniotic Membrane as the Carrier for ex Vivo Cell Culture for Cell Therapy in Ocular Surface Reconstruction
This clinical trial update discusses using human amniotic membrane as a carrier for ex vivo cell culture for cell therapy aimed at reconstru…