Leptomeningeal Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial update for HER2-directed CAR-T cells in patients with recurrent brain or leptomeningeal metastases from breast cancer…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis [Phase 1]
A Phase 1 clinical trial investigating Deferoxamine (DFO) for treating leptomeningeal metastases is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: Avelumab With Radiotherapy in Patients With Leptomeningeal Disease [Phase 1]
A Phase 1 trial evaluating the combination of avelumab with radiotherapy in patients with leptomeningeal disease/metastases has completed.
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors [Phase 2]
A Phase 2 trial comparing proton craniospinal radiation therapy versus partial photon radiation therapy for leptomeningeal metastases has co…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases [Phase 2]
A Phase 2 clinical trial is assessing furmonertinib in combination with intrathecal chemotherapy and stereotactic radiotherapy for EGFR-muta…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial assessing Sacituzumab Govitecan in combination with intrathecal chemotherapy for leptomeningeal metastases from H…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 2]
Phase 2 clinical trial evaluating high-dose Firmonertinib with Bevacizumab and intrathecal Pemetrexed for EGFR-mutated non-small cell lung c…
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CLINICAL_TRIALS research · 2025-03-06Clinical Trial Update: Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases [Phase 2]
A Phase 2 clinical trial at Zhejiang Cancer Hospital evaluates cerebrospinal fluid cytology-guided intrathecal chemotherapy with chemo-holid…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation [Phase 2]
Phase 2 trial evaluating Osimertinib in EGFR-mutant non-small cell lung cancer with brain or leptomeningeal metastases has completed. The st…
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study [Phase 2]
Phase II single-arm study evaluating furmonertinib plus bevacizumab as first-line therapy for EGFR-mutant non-small cell lung cancer with br…
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CLINICAL_TRIALS trial_result · 2024-02-13Clinical Trial Update: 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases [Phase 2, Phase 3]
Clinical trial update for 131I-omburtamab in neuroblastoma with CNS/leptomeningeal metastases shows terminated status with results posted.
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CLINICAL_TRIALS trial_result · 2023-04-24Clinical Trial Update: ANG1005 in Leptomeningeal Disease From Breast Cancer [Phase 3]
Phase 3 clinical trial update for ANG1005 in leptomeningeal disease from breast cancer (leptomeningeal carcinomatosis/metastases).
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CLINICAL_TRIALS trial_result · 2021-11-23Clinical Trial Update: Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases [Phase 2]
Phase 2 study of tesevatinib in subjects with non-small cell lung cancer and brain or leptomeningeal metastases has completed; results poste…
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CLINICAL_TRIALS trial_result · 2019-06-12Clinical Trial Update: Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer [Phase 3]
Phase 3 trial evaluating intrathecal liposomal cytarabine (DepoCyte) for leptomeningeal metastases from breast cancer has completed.
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CLINICAL_TRIALS trial_result · 2019-05-28Clinical Trial Update: Intrathecal Trastuzumab for Leptomeningeal Metastases in HER2+ Breast Cancer [Phase 1, Phase 2]
Phase 1/2 trial investigating intrathecal trastuzumab for leptomeningeal metastases in HER2-positive breast cancer has completed with result…
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CLINICAL_TRIALS trial_result · 2013-05-14Clinical Trial Update: Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma [Phase 2]
Phase 2 clinical trial of temozolomide for leptomeningeal metastases from solid tumors or lymphoma was terminated.
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CLINICAL_TRIALS trial_result · 2013-02-21Clinical Trial Update: Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment [Phase 2]
Phase 2 clinical trial evaluating topotecan hydrochloride for meningeal cancer in children unresponsive to prior treatment has been complete…
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CLINICAL_TRIALS withdrawal · 2012-11-09Clinical Trial Update: Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease [NA]
A clinical trial evaluating continuous intraventricular methotrexate for leptomeningeal metastases has been withdrawn.